5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a tryptamine derivative closely related to the neurotransmitter serotonin.

5-CT acts as a non-selective, high-affinity full agonist at the 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_5A, and 5-HT₇ receptors, as well as an agonist of the 5-HT₂, 5-HT₃, 5-HT₆ receptors with lower affinity. It has negligible affinity for the 5-HT_1E and 5-HT_1F receptors. 5-CT binds most strongly to the 5-HT_1A receptor and it was once thought to be selective for this site.

Recently, a close derivative of 5-CT, AH-494 has been shown to function as an agonist of 5-HT7, although being more selective over 5-HT1A. Structural study indicated residue Ser5x43 might play critical roles in the selectivity of 5-CT across the serotonin receptor family.

• 2-Methyl-5-hydroxytryptamine
• 5-Benzyloxytryptamine
• 5-Methoxytryptamine
• 5-Methyltryptamine
• α-Methyl-5-hydroxytryptamine
• Frovatriptan
• AH-494
• Acetryptine
• Sumatriptan