Allan Maxam
Allan Maxam | |
|---|---|
| Born | October 28, 1942 |
| Known for | Maxam–Gilbert sequencing |
| Scientific career | |
| Fields | Molecular genetics |
| Workplaces | Harvard University |
| Walter Gilbert | |
Allan Maxam (born October 28, 1942) is an American geneticist and one of the pioneers of molecular genetics. He co-developed the Maxam–Gilbert DNA sequencing method in 1976–1977 at Harvard University while working as a student in the laboratory of Walter Gilbert.
Maxam–Gilbert sequencing combined chemicals that cut DNA only at specific bases with radioactive labeling and polyacrylamide gel electrophoresis to determine the sequence of long DNA segments.
Their 1977 paper "A new method for sequencing DNA" was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society for 2017. It was presented to the Department of Molecular & Cellular Biology at Harvard University.
See also
References
- 1 2 Maxam, A M; Gilbert, W (1977), "A new method for sequencing DNA.", Proc. Natl. Acad. Sci. U.S.A., vol. 74, no. 2 (published February 1977), pp. 560–4, Bibcode:1977PNAS...74..560M, doi:10.1073/pnas.74.2.560, PMC 392330, PMID 265521
- ↑ DNA SEQUENCING AND GENE STRUCTURE, Walter Gilbert Nobel lecture, 8 December, 1980
- ↑ Maxam AM, Gilbert W, Sequencing end-labeled DNA with base-specific chemical cleavages, Methods Enzymol. 1980;65(1):499-560
- ↑ "Citations for Chemical Breakthrough Awards 2017 Awardees". Division of the History of Chemistry. Retrieved March 12, 2018.
Further reading
- Gilbert, Walter and Maxam. Allan, The Nucleotide Sequence of the Lac Operator, Proc. Natl. Acad. Sci. USA 70, 3581-3584 (1973).
- Maxam AM, Tizard R, Skryabin KG, Gilbert W, Promoter region for yeast 5S ribosomal RNA, Nature. 1977 June 16;267(5612):643-5
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