Mallotophenone

Mallotophenone
Names
	Preferred IUPAC name 1,1′-[Methylenebis(2,6-dihydroxy-4-methoxy-5-methyl-3,1-phenylene)]di(ethan-1-one)
Identifiers
CAS Number	98569-63-2;
3D model (JSmol)	Interactive image;
ChemSpider	155882;
KEGG	C10708;
PubChem CID	179090;
UNII	YV44LJT547 ;
CompTox Dashboard (EPA)	DTXSID70243720 ;
	InChI InChI=1S/C21H24O8/c1-8-16(24)14(10(3)22)18(26)12(20(8)28-5)7-13-19(27)15(11(4)23)17(25)9(2)21(13)29-6/h24-27H,7H2,1-6H3 Key: JXSPGOIAWPYMGS-UHFFFAOYSA-N; InChI=1/C21H24O8/c1-8-16(24)14(10(3)22)18(26)12(20(8)28-5)7-13-19(27)15(11(4)23)17(25)9(2)21(13)29-6/h24-27H,7H2,1-6H3 Key: JXSPGOIAWPYMGS-UHFFFAOYAZ;
	SMILES Cc1c(O)c(C(=O)C)c(O)c(c1OC)Cc(c(OC)c2C)c(O)c(C(C)=O)c2O;
Properties
Chemical formula	C21H24O8
Molar mass	404.415 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Mallotophenone is a dimeric phloroglucinol found in Mallotus oppositifolius or in Mallotus japonicus.

The bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of M. oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotophenone, together with mallotojaponins B and C. Diphenylmethanes are compounds that contain diphenylmethane moiety, which is a methane wherein two hydrogen atoms are replaced by two phenyl groups. Mallotophenone is strong as it has a very solid basic compound (based on its pKa).These compounds show antiproliferative and antiplasmodial activities. It’s chemical formula is C21H24O8.

References

↑ Harinantenaina, Liva; Bowman, Jessica D.; Brodie, Peggy J.; Slebodnick, Carla; Callmander, Martin W.; Rakotobe, Etienne; Randrianaivo, Richard; Rasamison, Vincent E.; Gorka, Alexander; Roepe, Paul D.; Cassera, Maria B.; Kingston, David G. I. (2013). "Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest(1)". Journal of Natural Products. 76 (3): 388–93. doi:10.1021/np300750q. PMC 3606680. PMID 23286240.

2. PhytoBank: Showing mallotophenone (PHY0034926). (n.d.). PhytoBank. https://phytobank.ca/metabolites/PHY0034926

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[1] Harinantenaina, Liva; Bowman, Jessica D.; Brodie, Peggy J.; Slebodnick, Carla; Callmander, Martin W.; Rakotobe, Etienne; Randrianaivo, Richard; Rasamison, Vincent E.; Gorka, Alexander; Roepe, Paul D.; Cassera, Maria B.; Kingston, David G. I. (2013). "Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest(1)". Journal of Natural Products. 76 (3): 388–93. doi:10.1021/np300750q. PMC 3606680. PMID 23286240.