C5a receptor
The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor. C5a receptor 1 modulates inflammatory responses, obesity, development and cancers. From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a, coupling of Gαi proteins, ERK1/2 phosphorylation, calcium mobilization and Rho activation leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.
Cells
The C5a receptor 1 is expressed on:
- Granulocytes
- Macrophages
- Monocytes
- Dendritic cells
- Hepatoma-derived cell line HepG2
- Astrocytes
- Microglia
Agonist and antagonists
Potent and selective agonist and antagonists for C5a receptor 1 have been developed.
See also
- Complement component 5a for binding mechanism
References
Further reading
External links
- "Anaphylatoxin Receptors: C5a". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-04-07. Retrieved 2007-10-25.
- C5a+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human C5AR1 genome location and C5AR1 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P21730 (C5a anaphylatoxin chemotactic receptor 1) at the PDBe-KB.