Macrophage-capping protein

CAPG
Identifiers
Aliases	CAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDs	OMIM: 153615; MGI: 1098259; GeneCards: CAPG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J72, 1JHW
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,418,432 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,539,966 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of abdomen; ; left lobe of thyroid gland; ; granulocyte; ; right lobe of thyroid gland; ; skin of leg; ; upper lobe of left lung; ; right lung; ; ectocervix; ; gums;
	Top expressed in
	granulocyte; ; corneal stroma; ; lip; ; decidua; ; ankle joint; ; conjunctival fornix; ; esophagus; ; stroma of bone marrow; ; gastrula; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; actin binding; protein binding; protein domain specific binding; cadherin binding; actin filament binding;
Cellular component	cytoplasm; F-actin capping protein complex; melanosome; centriole; mitotic spindle; nucleolus; extracellular exosome; nucleus; Flemming body; nucleoplasm; extracellular region; ruffle; lamellipodium; cell projection;
Biological process	barbed-end actin filament capping; extracellular matrix disassembly; positive regulation of podosome assembly; actin filament capping; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	822
	12332
	ENSG00000042493
	ENSMUSG00000056737
	P40121
	P24452
NM_001256139; NM_001256140; NM_001747; NM_001320732; NM_001320733;
	NM_001320734
	NM_001042534; NM_001271395; NM_001271415; NM_007599
NP_001243068; NP_001243069; NP_001307661; NP_001307662; NP_001307663;
	NP_001738
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dabiri GA, Young CL, Rosenbloom J, Southwick FS (September 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". The Journal of Biological Chemistry. 267 (23): 16545–16552. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.
↑ Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, et al. (July 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". The Journal of Biological Chemistry. 278 (31): 29136–29144. doi:10.1074/jbc.M300598200. PMID 12754261.
1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
↑ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (November 2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11). Hoboken, N.J.: 775–795. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Southwick FS (January 1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G". The Journal of Biological Chemistry. 270 (1): 45–48. doi:10.1074/jbc.270.1.45. PMID 7814409.
Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location". Genomics. 23 (3): 560–565. doi:10.1006/geno.1994.1543. PMID 7851883.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell. 89 (4): 511–521. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743. S2CID 15061740.
Cabello OA, Eliseeva E, He WG, Youssoufian H, Plon SE, Brinkley BR, et al. (November 2001). "Cell cycle-dependent expression and nucleolar localization of hCAP-H". Molecular Biology of the Cell. 12 (11): 3527–3537. doi:10.1091/mbc.12.11.3527. PMC 60273. PMID 11694586.
Van Impe K, De Corte V, Eichinger L, Bruyneel E, Mareel M, Vandekerckhove J, et al. (May 2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". The Journal of Biological Chemistry. 278 (20): 17945–17952. doi:10.1074/jbc.M209946200. PMID 12637565.
De Corte V, Van Impe K, Bruyneel E, Boucherie C, Mareel M, Vandekerckhove J, et al. (October 2004). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion". Journal of Cell Science. 117 (Pt 22): 5283–5292. doi:10.1242/jcs.01410. PMID 15454578.
Watari A, Takaki K, Higashiyama S, Li Y, Satomi Y, Takao T, et al. (November 2006). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–7380. doi:10.1038/sj.onc.1209732. PMID 16767159.
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, et al. (November 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–3144. doi:10.1021/pr060363j. PMID 17081065.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Dabiri_1992-5] Dabiri GA, Young CL, Rosenbloom J, Southwick FS (September 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". The Journal of Biological Chemistry. 267 (23): 16545–16552. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.

[Pellieux_2003-6] Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, et al. (July 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". The Journal of Biological Chemistry. 278 (31): 29136–29144. doi:10.1074/jbc.M300598200. PMID 12754261.

[entrez-7] 1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".

[8] Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (November 2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11). Hoboken, N.J.: 775–795. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Macrophage-capping protein

Function

References

Further reading