CHRNA2

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Knockout of this gene in mice potentiates nicotine-modulated behaviors. Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice.

• Nicotinic acetylcholine receptor

• CHRNA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNA2 genome location and CHRNA2 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.