CRTC2
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.
Function
CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP. CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).
Interactions
CRTC2 has been shown to interact with SNF1LK2 and YWHAQ.
References
Further reading
External links
- CRTC2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q53ET0 (Human CREB-regulated transcription coactivator 2) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q3U182 (Mouse CREB-regulated transcription coactivator 2) at the PDBe-KB.