Cruz del Sur ("Southern Cross") may refer to:
- Cruz del Sur pipeline, gas pipeline between Argentina and Uruguay
- Cruz del Sur de Bariloche, Argentine football club
- Cruz del Sur Music, Italian record label.
- Cruz del Sur, fictional prison in Locked Up (TV series)
- Cruz del Sur, expansion pack to the computer game Uncharted Waters Online
- Cruz del Sur Incident, see List of incidents during the Beagle conflict
This disambiguation page lists articles associated with the title Cruz del Sur.
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