Cysteate synthase

Cysteate synthase
Identifiers
EC no.2.5.1.76
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Cysteate synthase (EC 2.5.1.76) is an enzyme characterised from Methanosarcinales with systematic name sulfite:O-phospho-L-serine sulfotransferase (phosphate-hydrolysing, L-cysteate-forming). It catalyses the following chemical reaction which produces L-cysteic acid by reacting phosphoserine with sulfite (H2SO3), giving orthophosphate (Pi) as a byproduct:

2D representation of the chemical structure of phosphoserine .
phosphoserine
+ H2SO3
 
 
 
Rightward reaction arrow with minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q29743881.
L-cysteic acid

This enzyme is a transferase containing pyridoxal-phosphate as a cofactor.

References

  1. 1 2 Enzyme 2.5.1.76 at KEGG Pathway Database.
  2. ↑ Graham DE, Taylor SM, Wolf RZ, Namboori SC (December 2009). "Convergent evolution of coenzyme M biosynthesis in the Methanosarcinales: cysteate synthase evolved from an ancestral threonine synthase". The Biochemical Journal. 424 (3): 467–78. doi:10.1042/BJ20090999. PMID 19761441.