DFNB31

Whirlin is a protein that in humans is encoded by the DFNB31 gene.

In rat brain, WHRN interacts with a calmodulin-dependent serine kinase, CASK, and may be involved in the formation of scaffolding protein complexes that facilitate synaptic transmission in the central nervous system (CNS). Mutations in this gene, also known as WHRN, cause autosomal recessive deafness.

• GeneReviews/NCBI/NIH/UW entry on Usher Syndrome Type II