Exosite
An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.
This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied. Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.
References
External links
- Arnaud, E; Lafay, M; Gaussem, P; Picard, V; Jandrot-Perrus, M; Aiach, M; Rendu, F (15 September 1994). "An autoantibody directed against human thrombin anion-binding exosite in a patient with arterial thrombosis: effects on platelets, endothelial cells, and protein C activation". Blood. 84 (6): 1843–1850. doi:10.1182/blood.V84.6.1843.1843. PMID 8080990.