Eye neoplasm

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Eye neoplasm
Other names	Ocular tumor
Melanotic sarcoma through the conjunctiva and sclerotic along the lower border of the cornea
Specialty	Oncology
Symptoms	Vision problems (such as blurry or distorted vision), floaters, bulging of the eye, change in eyeball position within socket, growing dark spot on the iris or white part of the eye.
Treatment	Brachytherapy (episcleral plaque therapy), proton therapy, chemotherapy, enucleation, Laser Therapy, among others.
Frequency	~3,200 new cases per year in the United States
Deaths	~530 deaths per year in the United States

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An eye neoplasm is a rare type of tumor of the eye. Eye neoplasms can affect all parts of the eye, and can either be benign (noncancerous) or malignant (cancerous), in which case it is known as eye cancer. Eye cancers can be primary (starts within the eye) or metastatic cancer (spread to the eye from another organ). The two most common cancers that spread to the eye from another organ are breast cancer and lung cancer. Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow.

Types

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Signs and symptoms

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• Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is a tumor until an ophthalmologist or optometrist looks into the eye with an ophthalmoscope during a routine test). As the tumor grows, symptoms can be blurred vision, decreased vision, double vision, eventual vision loss and if they continue to grow the tumor can break past the retina causing retinal detachment. Sometimes the tumor can be visible through the pupil.
• A nevus is a benign, freckle in the eye. These should be checked out and regular checks on the eye done to ensure it has not turned into a melanoma.
• Iris and conjuctival tumors (melanomas) - Present as a dark spot. Any spot which continues to grow on the iris and the conjunctiva should be checked out.
• Retinoblastoma - Strabismus (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. Retinoblastoma can occur in one or both eyes. This tumor occurs in babies and young children. It is called RB for short. Check photographs, normal healthy eyes would have the red eye reflex, but a white/yellow dot instead of the red eye reflex can indicate a tumor or some other kind of eye disease. Any photos of a child/children which have a white/yellow dot instead of the red eye reflex should be evaluated by an eye doctor.

Diagnosis

Classification

Choroidal tumors

• Choroidal hemangioma
• Choroidal melanoma
• Choroidal metastasis
• Choroidal nevus
• Choroidal osteoma
• Ciliary body melanoma
• The nevus of Ota

Conjunctival tumors

• Conjunctival Kaposi's sarcoma
• Epibulbar dermoid
• Malignant conjunctival tumors
• Lymphoma of the conjunctiva
• Melanoma and PAM with atypia
• Pigmented conjunctival tumors
• Pingueculum
• Pterygium
• Squamous carcinoma and intraepithelial neoplasia of the conjunctiva

Treatment

The following are used in treatment:

• Laser therapy
• Brachytherapy (episcleral plaque therapy) - referred to as "the most common radiation treatment for eye melanoma. Studies have shown that it is as effective as removing the eye with surgery (enucleation)."
• Radiotherapy - The ophthalmologist decides in conjunction with the radiation oncologist which type of radiation therapy is most suitable, based on size and location of the tumour. Today, modern radiation treatment modalities, such as proton therapy, are likely to be chosen, for providing superior accuracy in dose delivery, helping to spare healthy tissue and the sensitive optic nerves.
• Proton therapy – A type of radiation therapy that uses protons instead of X-rays. "for eye melanomas, proton beam radiation therapy might be a better option than brachytherapy if the tumor cannot be completely covered with a plaque because of its size, shape, or location. For example, it’s used more often for larger tumors or tumors close to the optic nerve."
• Enucleation of the eye - Removal of the eye, but the muscles and eyelids are left intact. An implant is inserted, then the person wears a conformer shield and later the person will have their prosthesis made and fitted (the prosthesis is made by an ocularist and is made to look like the person's real eye)^{[citation needed]}
• Evisceration - Removal of the eye contents, leaving the sclera or the white part of the eye.^{[citation needed]}
• Exenteration - Removal of the eye, all orbital contents, which can involve the eyelids as well. A special prosthesis is made to cover the defect and improve appearance.^{[citation needed]}
• Iridectomy - Removal of the affected piece of the iris^{[citation needed]}
• Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina)^{[citation needed]}
• Iridocyclectomy - Removal of the iris plus the ciliary body muscle.^{[citation needed]}
• Eyewall resection - Cutting into the eye to remove a tumor e.g. melanoma. This operation can be quite difficult to perform.^{[citation needed]}
• Chemotherapy^{[citation needed]}

Ocular oncology

Ocular oncology is the branch of medicine dealing with tumors relating to the eye and its adnexa.^{[citation needed]}

Ocular oncology takes into consideration that the primary requirement for patients is preservation of life by removal of the tumor, along with best efforts directed at preservation of useful vision, followed by cosmetic appearance. The treatment of ocular tumors is generally a multi-specialty effort, requiring coordination between the ophthalmologist, medical oncologist, radiation specialist, head & neck surgeon/ENT surgeon, pediatrician/internal medicine/hospitalist and a multidisciplinary team of support staff and nurses.^{[citation needed]}

References

External links

• "EyeRounds".
• Eye Cancer - Medline Plus
• Ocular Oncology - Bascom Palmer Eye Institute
• Exophthalmos (Proptosis) at eMedicine