Iglv6-57

IGLV6-57
Identifiers
AliasesIGLV6-57, V1-22, immunoglobulin lambda variable 6-57
External IDsGeneCards: IGLV6-57
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

28778

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Ensembl

ENSG00000211640

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)Chr 22: 22.2 – 22.2 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

Immunoglobulin lambda variable 6-57 is a protein which is encoded by the IGLV6-57 gene in humans.

This gene is primarily expressed in the lymphatic system. IGLV6-57 is an extracellular protein that has been predicted to reside within the cytoplasm of cells. The function of IGLV6-57 is predicted to be involved in the immune response and enabling antigen binding activity. This prediction also matches with pathogen recognition from antibodies utilizing IGLV6-57 light chains.

Gene

Aliases

Known aliases of IGLV6-57 include V1-22 or IGLV657.

Locus

Human IGLV6-57 gene is found on the forward (+) strand at the locus NC_000022.11. The gene ranges from position 22026076 to position 22922913 on chromosome 22.

mRNA

IGLV6-57's transcript is reported to be around 478 nucleotides long. It has two exons separated between one intron.

Expression pattern

IGLV6-57 is moderately expressed in spleen, lymph node, and tonsil tissue.

Transcript

IGLV6-57 gene contains no alternatively spliced forms because it is an immunoglobulin variable-region gene segment, not a complete antibody gene.

Protein

Protein characteristics

The predicted molecular weight of IGLV6-57 is 12.566 kDa, and it has a predicted isoelectric point (pI) of pH 4.59. In terms of amino acid composition, IGLV6-57 has a relatively proportion of polar amino acids serine, glycine, and threonine. It also is relatively poor in histidine, methionine, and tryptophan.

Isoforms

Immunoglobulin Lambda Variable 6-57 primarily expresses a single protein isoform.

Secondary structure

The predicted secondary structure of IGLV6-57 is composed primarily of β strands.

Teritiary structure

The predicted teritiary structure of IGLV6-57 consists of two antiparallel β sheets stabilized by conserved intradomain disulfide bond.

Post-translational modifications

Disulfide bond formation

Conceptual translation of human IGLV6-57 mRNA revealed two conserved cysteine residues at position 20 and 89 and are predicted to form an intradomain disulfide bond.

Cellular localization

Computational prediction have identifies the IGLV6-57 protein in the extracellular and cytoplasm location. IGLV6-57 is predicted to be a soluble protein.

Regulation and expression

Promoters

No promoter was identified in the analyzed upstream sequence of IGLV6-57 using computational promoter prediction methods.

Transcription factors

The following table summarizes transcription factors predicted to bind highly conserved regions of the IGLV6-57 sequence.

Selected transcription factors predicted to bind to highly conserved regions of IGLV6-57
Transcription Factor Description
MAFG bZip Maf transcription factor protein
MAFK bZip Maf transcription factor protein
MAFA β cell-specific activator

Expression

Tissue specificity

According to RNA-seq data, IGLV6-57 is expressed most highly in lymph node, spleen, and appendix tissue.

Embryonic development

IGLV6-57 expression is highest in the fetal adrenal gland during mid-gestation (16–18 weeks), with lower expression in several other fetal tissues. No specific role in embryonic development has been established.

Differential expression

IGLV6-57 has been observed to be expressed at higher levels in beta-catenin-depleted cells than in untreated control cells.

IGLV6-57 has been observed to be expressed at higher levels in tumor tissue than in adjacent normal tissue.

Interacting proteins

The StringNetwork database indicates that the following proteins have been found to interact with the IGLV6-57 protein.

Protein Description
FCAR binds the heavy-chain constant region of Immunoglobulin A (IgA) antibodies
CD5 cluster of differentiation expressed on the surface of T cells
TFPI single-chain polypeptide which can reversibly inhibit factor Xa (Xa)

Homology and evolution

Orthologs

IGLV6-57 has orthologs in Mammalia, Aves, Reptillia, and Amphibia. A table of selected orthologs is listed below.

Selected orthologs of the homo sapiens IGLV6-57 protein

Genus and Species Common Name Taxonomic Group Date of Divergence from Humans (MYA) Accession Number # Sequence Length Sequence Identity
Homo sapiens Human Primates 0 NP_037510.1 116 aa 43%
Mus musculus House mouse Placental 87 NP_001415808.1 130 aa 68%
Saccopteryx bilineata Greater sac-winged bat Chiroptera 94 XP_066116077.1 121 aa 86%
Phascolarctos cinereus Koala Marsupials Mammal 160 XP_020833304.1 123 aa 69%
Ornithorhynchus anatinus Platypus Monotremes 180 XP_028904584.1 123 aa 63%
Athene noctua Little owl Aves 319 XP_074777375.1 272 aa 58%
Centrocercus urophasianus Greater sage-grouse Aves 319 XP_042685107.1 125 aa 56%
Pseudonaja textilis Eastern brown snake Squamata 319 XP_026574391.1 110 aa 61%
Crocodylus porosus Saltwater crocodile Crocodilia 319 XP_019394969.1 125 aa 59%
Pelodiscus sinensis Chinese softshell turtle Testudines 319 XP_075753974.1 137 aa 59%
Bufo bufo Common toad Anura 352 XP_040275605.1 239 aa 53%
Ambystoma mexicanum Axolotl Caudata 352 XP_069476393.1 144 aa 48%
Hyla sarda Sardinian tree frog Anura 352 XP_056387603.1 130 aa 46%
Rhinatrema bivittatum Two-lined caecilian Gymnophiona 352 XP_029426890.1 127 aa 51%

Evolutionary history

IGLV6-57 is not a highly conserved gene due to evolutionary divergence driven by the adaptive immune system. The most evolutionary distant ortholog of IGLV6-57 is in the Sardinian tree frog (Hyla sarda); and it is conserved from Amphibia to Mammalia, with no detectable orthologs in invertebrates.

Paralogs

IGLV6-57 contains numerous paralogous genes located within the immunoglobulin lambda locus on chromosome 22.

Paralog genes located within the immunoglobulin lambda locus on chromosome 22
Paralog Description
IGLVV-58 antigen recognition
IGLV11-55 non-functional immunoglobulin lambda variable gene
IGLV1-56 antigen recognition
BMP6P1 pseudogene

Clinical significance

IGLV6-57 has been a linked site for an amyloid-associated residue change associated with AL amyloidosis. Additionally, proteins from this specific lambda light chain class is likely to unfold, exposing the hydrophobic core of the protein. Due to structural instability, the IGLV6-57 gene segment frequently misfolds.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000211640 – Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 "Tissue expression of IGLV6-57 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2026-06-04.
  4. 1 2 "6A1F0DEB00397ED2DA07BE6E expired". services.healthtech.dtu.dk. Retrieved 2026-06-04.
  5. 1 2 "IGLV6-57 (human)". www.phosphosite.org. Retrieved 2026-06-04.
  6. 1 2 3 4 "IGLV6-57 immunoglobulin lambda variable 6-57 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2026-06-07.
  7. 1 2 "Homo sapiens IGL mRNA for immunoglobulin lambda light chain VLJ region - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2026-06-04.
  8. ↑ "Variation Viewer". www.ncbi.nlm.nih.gov. Retrieved 2026-06-04.
  9. ↑ GeneCards HG. "IGLV6-57 Gene - GeneCards | LV657 Protein | LV657 Antibody". www.genecards.org. Archived from the original on 2022-12-29. Retrieved 2026-06-06.
  10. ↑ European Bioinformatics Institute. "Job Dispatcher homepage | EMBL-EBI". www.ebi.ac.uk. Retrieved 2026-06-08.
  11. 1 2 "iCn3D: Web-based 3D Structure Viewer". www.ncbi.nlm.nih.gov. Retrieved 2026-06-07.
  12. ↑ "Six-Frame Translation". www.bioline.com. Retrieved 2026-06-07.
  13. ↑ "Jpred job jp_6VX6dfa completed". www.compbio.dundee.ac.uk. Retrieved 2026-06-07.
  14. ↑ "6A25C05E001766B150664E8F expired". services.healthtech.dtu.dk. Retrieved 2026-06-07.
  15. ↑ "Sequence Utilities". www.bioline.com. Retrieved 2026-06-07.
  16. 1 2 "VPREB3 V-set pre-B cell surrogate light chain 3 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2026-06-07.
  17. ↑ "61450730 - GEO Profiles - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2026-06-07.
  18. ↑ "17269155 - GEO Profiles - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2026-06-07.
  19. ↑ "STRING: functional protein association networks". string-db.org. Retrieved 2026-06-07.
  20. 1 2 "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2026-06-08.
  21. ↑ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2026-06-07.
  22. ↑ Morgan GJ, Prokaeva T (2025). "Clone-specific residue changes at multiple positions are associated with amyloid formation by antibody light chains". Frontiers in Immunology. 16 1622207. doi:10.3389/fimmu.2025.1622207. PMC 12375997. PMID 40861476.