Jacques Loeb

Jacques Loeb (/loʊb/;

German: [løːp]; April 7, 1859 – February 11, 1924) was a German-born American physiologist and biologist.

Jacques Loeb, born Itzak, firstborn son of a Jewish family from the German Eifel region, was educated at the universities of Berlin, Munich, and Strasburg (M.D. 1884). He took postgraduate courses at the universities of Strasburg and Berlin, and in 1886 became assistant at the physiological institute of the University of Würzburg, remaining there until 1888. In a similar capacity, he then went to Strasburg University. During his vacations he pursued biological research, at Kiel in 1888, and at Naples in 1889 and 1890.

Loeb first arrived in the United States in 1891 when he accepted a position at Bryn Mawr College. The College, however, provided insufficient facilities for his work, leading to his resignation. In 1892, he was called to the University of Chicago as assistant professor of physiology and experimental biology, becoming associate professor in 1895, and professor of physiology in 1899. John B. Watson (the "father of Behaviorism") attended Loeb's neurology classes at the University of Chicago. He was elected a member to the American Philosophical Society in 1899. In 1902, he was called to fill a similar chair at the University of California, Berkeley. Loeb was among the professors who had summer homes on "Professors' Row", near the sea cliffs in Carmel, California; John Fleming Wilson called Carmel Point "Point Loeb" after him.

In 1910, Loeb moved to the Rockefeller Institute for Medical Research in New York, where he headed a new departmen, He remained at the Institute, now Rockefeller University, until his death. Loeb spent summers at the Marine Biological Laboratory in Woods Hole, Massachusetts, performing experiments on marine invertebrates. These included an experiment on artificial parthenogenesis. Loeb was able to switch the sea urchins' eggs to starting embryonic development without sperm. Modifications of the water in which the eggs were kept served as the stimulus for the development to begin. Later in 1918, Loeb established and became the first Editor of the Journal of General Physiology.

Jacques Loeb became one of the most famous scientists in America, widely covered in newspapers and magazines, influencing other important individuals in the scientific world such as B.F. Skinner. He was the model for the character of Max Gottlieb in Sinclair Lewis's Pulitzer-winning novel Arrowsmith, the first great work of fiction to idealize and idolize pure science. Mark Twain also wrote an essay titled "Dr. Loeb's Incredible Discovery", urging the reader not to support a rigid general consensus, but to instead be open to new scientific advances.

Loeb was nominated many times for the Nobel Prize but never won.

Dr. Loeb was an atheist. He died of coronary artery disease while vacationing in Bermuda in 1924.

The main subjects of Loeb's work were:

• Animal tropisms and their relation to the instincts of animals
• Heteromorphosis, the replacement of an injured or removed organ by a different organ
• Toxic and antitoxic effects of ions
• Artificial parthenogenesis
• Hybridization of the eggs of sea-urchins by the sperm of starfish

Among Loeb's works the following may be mentioned:

• Der Heliotropismus der Thiere und seine Uebereinstimmung mit dem Heliotropismus der Pflanzen, Würzburg: Verlag von Georg Hertz, 1890.
• Untersuchungen zur physiologischen Morphologie der Thiere, Würzburg: Verlag von Georg Hertz, 1891–1892. 2 vols., vol. 1: Ueber Heteromorphose, vol. 2: Organbildung und Wachsthum.
• Einleitung in die vergleichende Gehirnphysiologie und vergleichende Psychologie, Leipzig: J. A. Barth, 1899. English ed., Comparative physiology of the brain and comparative psychology, New York: Putnam, 1900.
• Studies in general physiology, Chicago: The University of Chicago Press, 1905.
• The dynamics of living matter, New York: Columbia University Press, 1906.
• The mechanistic conception of life: biological essays, Chicago: The University of Chicago Press, 1912; reprint, Cambridge, Mass.: Harvard University Press, 1964.
• Artificial parthenogenesis and fertilization, tr. from German by W. O. Redman King, rev. and ed. by Loeb. Chicago: The University of Chicago Press, 1913.
• The organism as a whole, from a physicochemical viewpoint, New York: Putnam, 1916.
• Forced movements, tropisms, and animal conduct, Philadelphia: Lippincott, 1918.
• Proteins and the theory of colloidal behavior, New York: McGraw-Hill, 1922.

The Mechanistic Conception of Life is Loeb's most famous and influential work. It contains English translations of some of his previous publications in German.

His younger brother Leo also emigrated to the United States where he became a noted pathologist.

•  This article incorporates text from a publication now in the public domain: Singer, Isidore; et al., eds. (1901–1906). The Jewish Encyclopedia. New York: Funk & Wagnalls. {{cite encyclopedia}}: Missing or empty |title= (help)

• Jacques Loeb at The Embryo Project Encyclopedia.
• Loeb Family Tree
• Jacques Loeb at the Jewish Encyclopedia.
• Jacques Loeb at infoplease.com.
• National Academy of Sciences Biographical Memoir