Yoshito Kishi

Yoshito Kishi
Kishi in 2003
Born(1937-04-13)13 April 1937
Nagoya, Japan
Died9 January 2023(2023-01-09) (aged 85)
EducationNagoya University (BS, PhD)
Scientific career
FieldsOrganic chemistry
WorkplacesNagoya University
Harvard University
Thesisウミホタルルシフェリンの構造とその全合成 (1966)
Yoshimasa Hirata
Doctoral students
Tohru Fukuyama
Stuart L. Schreiber
Other notable students
René Peters (chemist)

Yoshito Kishi (岸 義人, Kishi Yoshito; 13 April 1937 – 9 January 2023) was a Japanese chemist who was the Morris Loeb Professor of Chemistry at Harvard University. He was known for his contributions to the sciences of organic synthesis and total synthesis.

Early life and education

Kishi was born in Nagoya, Japan and attended Nagoya University, where he obtained both his BS and PhD degrees. He was a postdoctoral research fellow at Harvard University where he worked with Robert Burns Woodward. From 1966 through 1974, he was a professor of chemistry at Nagoya University. In 1974, Kishi joined the faculty of Harvard's Department of Chemistry, where he rose through the academic ranks to ultimately become Morris Loeb Professor of Chemistry, a position he held until his death in 2023.

Kishi's research focused on the total synthesis of complex natural products. The accomplishments of his research group include the total syntheses of palytoxin, mycolactones, halichondrins, saxitoxin, tetrodotoxin, geldanamycin, batrachotoxin and many others. Kishi also contributed to the development of new chemical reactions including the Nozaki–Hiyama–Kishi reaction. Kishi's total synthesis of halichondrin B was pivotal for the discovery and development of the anticancer drug eribulin, a fully synthetic, pharmaceutically optimized macrocyclic ketone analog of halichondrin B.

Recognition

See also

References

  1. ↑ 岸義人氏が死去　天然物有機化学者 (in Japanese)
  2. ↑ Williams, Robert M. (2007). "Preface: Honoring the 70th Birthday of Professor Yoshito Kishi". Heterocycles. 72 (1): 1–3. doi:10.3987/2007-72-0001.
  3. 1 2 3 Kishi, Yoshito; Rando, Robert R. (1998). "Structural Basis of Protein Kinase C Activation by Tumor Promoters". Accounts of Chemical Research. 31 (4): 9672–6. doi:10.1021/ar9600751. PMC 298563. PMID 2602368.
  4. ↑ Chaudhry, Yahya (31 January 2023). "Yoshito Kishi, 86, remembered for developing important anti-cancer agent". Harvard Gazette. Retrieved 26 February 2023.
  5. ↑ Wang, Austin H. (21 March 2023). "Yoshito Kishi, Organic Chemist Who Climbed 'Mount Everest' of Synthesis, Dies at 85". Harvard Crimson. Retrieved 25 March 2023.
  6. ↑ Yoshito Kishi Archived October 18, 2010, at the Wayback Machine, Department of Chemistry and Chemical Biology, Harvard University
  7. ↑ Lowe, Derek (January 18, 2023). "Prof. Yoshito Kishi, 1937-2023". Science. Retrieved 26 February 2023.
  8. ↑ Krietsch Boerner, Leigh (January 24, 2023). "Organic chemist Yoshito Kishi dies at 85". Chemical & Engineering News. 101 (4). Retrieved 26 February 2023.
  9. ↑ Takai, K.; Tagashira, M.; Kuroda, T.; Oshima, K.; Utimoto, K.; Nozaki, H. (1986). "Reactions of alkenylchromium reagents prepared from alkenyl trifluoromethanesulfonates (triflates) with chromium(II) chloride under nickel catalysis". Journal of the American Chemical Society. 108 (19): 6048–50. Bibcode:1986JAChS.108.6048T. doi:10.1021/ja00279a068. PMID 22175376.
  10. ↑ Aicher, Thomas D.; Buszek, Keith R.; Fang, Francis G.; Forsyth, Craig J.; Jung, Sun Ho; Kishi, Yoshito; Matelich, Michael C.; Scola, Paul M.; Spero, Denice M.; Yoon, Suk Kyoon (April 1992). "Total synthesis of halichondrin B and norhalichondrin B". Journal of the American Chemical Society. 114 (8): 3162–3164. doi:10.1021/ja00034a086. ISSN 0002-7863.
  11. ↑ Towle, M. J.; Salvato, K. A.; Budrow, J.; Wels, B. F.; Kuznetsov, G.; Aalfs, K. K.; Welsh, S.; Zheng, W.; Seletsky, B. M.; Palme, M. H.; Habgood, G. J.; Singer, L. A.; Dipietro, L. V.; Wang, Y.; Chen, J. J. (2001-02-01). "In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B". Cancer Research. 61 (3): 1013–1021. ISSN 0008-5472. PMID 11221827.
  12. ↑ Yu, MJ; Kishi, Y; Littlefield, BA (2012). "Discovery of E7389, a fully synthetic macrocyclic ketone analogue of halichondrin B". In Cragg, GM; Kingston, DGI; Newman, DJ (eds.). Anticancer agents from natural products (2nd ed.). Boca Raton, FL: CRC Press. pp. 317–345. ISBN 978-1-4398-1382-9.
  13. ↑ "Tetrahedron Prize for Creativity in Organic Chemistry or Bioorganic & Medicinal Chemistry". Elsevier. Archived from the original on September 9, 2014. Retrieved 28 January 2015.