Lactate dehydrogenase B

LDHB
Identifiers
Aliases	LDHB, HEL-S-281, LDH-B, LDH-H, LDHBD, TRG-5, lactate dehydrogenase B
External IDs	OMIM: 150100; MGI: 96763; GeneCards: LDHB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I0Z, 1T2F
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	21,757,857 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,453,683 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; right ventricle; ; external globus pallidus; ; endothelial cell; ; lateral nuclear group of thalamus; ; myocardium of left ventricle; ; pars compacta; ; pars reticulata; ; kidney tubule; ; middle temporal gyrus;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; right kidney; ; right ventricle; ; primary visual cortex; ; superior frontal gyrus; ; vestibular membrane of cochlear duct; ; anterior horn of spinal cord; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; lactate dehydrogenase activity; protein binding; kinase binding; NAD binding; catalytic activity; L-lactate dehydrogenase activity; identical protein binding;
Cellular component	extracellular exosome; membrane raft; membrane; myelin sheath; mitochondrion; cytoplasm; cytosol;
Biological process	NAD metabolic process; lactate metabolic process; carboxylic acid metabolic process; pyruvate metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	3945
	16832
	ENSG00000111716
	ENSMUSG00000030246
	P07195
	P16125
	NM_001174097; NM_002300; NM_001315537
	NM_008492; NM_001302765; NM_001316322
	NP_001167568; NP_001302466; NP_002291
	NP_001289694; NP_001303251; NP_032518
	Wikidata
View/Edit Human	View/Edit Mouse

Lactate dehydrogenase B is a protein that in humans is encoded by the LDHB gene.

Function

This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111716 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030246 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Lactate dehydrogenase B". Retrieved 2017-10-01.

Philibert RA, Nelson JJ, Sandhu HK, Crowe RR, Coryell WH (2003). "Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 117B (1): 11–7. doi:10.1002/ajmg.b.10015. PMID 12555229. S2CID 25994539.
Mazzotta S, Guerranti R, Gozzetti A, Bucalossi A, Bocchia M, Sammassimo S, Petralia S, Ogueli GI, Lauria F (2006). "Increased serum lactate dehydrogenase isoenzymes in Ph-negative chronic myeloproliferative diseases: a metabolic adaptation?". Hematology. 11 (4): 239–44. doi:10.1080/10245330600774835. PMID 17178662. S2CID 36110689.
de Haas T, Hasselt N, Troost D, Caron H, Popovic M, Zadravec-Zaletel L, Grajkowska W, Perek M, Osterheld MC, Ellison D, Baas F, Versteeg R, Kool M (2008). "Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression". Clin. Cancer Res. 14 (13): 4154–60. doi:10.1158/1078-0432.CCR-07-4159. PMID 18593994.
Whyte MP, Kempa LG, McAlister WH, Zhang F, Mumm S, Wenkert D (2010). "Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders". J. Bone Miner. Res. 25 (11): 2515–26. doi:10.1002/jbmr.130. PMID 20499337. S2CID 22022750.
Egberts F, Momkvist A, Egberts JH, Kaehler KC, Hauschild A (2010). "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients". Anticancer Res. 30 (5): 1799–805. PMID 20592382.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9) e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
Swiderek K, Paneth P (2011). "Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase". Arch. Biochem. Biophys. 505 (1): 33–41. doi:10.1016/j.abb.2010.10.010. PMID 20951115.
Zha X, Wang F, Wang Y, He S, Jing Y, Wu X, Zhang H (2011). "Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis". Cancer Res. 71 (1): 13–8. doi:10.1158/0008-5472.CAN-10-1668. PMID 21199794.
Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee SJ, Yoon G (2011). "Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects". Exp. Cell Res. 317 (8): 1108–18. doi:10.1016/j.yexcr.2011.02.011. PMID 21356207.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111716 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030246 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lactate dehydrogenase B". Retrieved 2017-10-01.

Lactate dehydrogenase B

Function

References

Further reading