LPAR2

LPAR2
Identifiers
Aliases	LPAR2, EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs	OMIM: 605110; MGI: 1858422; GeneCards: LPAR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P0C
Gene location (Human)
Chr.	Chromosome 19 (human)
End	19,628,930 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	70,283,752 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; granulocyte; ; blood; ; right testis; ; spleen; ; left testis; ; monocyte; ; mucosa of transverse colon; ; right lung;
	Top expressed in
	granulocyte; ; yolk sac; ; epiblast; ; tail of embryo; ; otic vesicle; ; genital tubercle; ; ventricular zone; ; ganglion of vagus nerve; ; primitive streak; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	lipid binding; protein binding; lysophosphatidic acid receptor activity; signal transducer activity; G protein-coupled receptor activity;
Cellular component	integral component of plasma membrane; membrane; endocytic vesicle; integral component of membrane; plasma membrane; cell surface;
Biological process	activation of phospholipase C activity; signal transduction; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9170
	53978
	ENSG00000064547
	ENSMUSG00000031861
	Q9HBW0
	Q9JL06; Q6P290
	NM_004720; NM_001395660
	NM_020028
	NP_004711
	NP_064412
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.

Interactions

LPAR2 has been shown to interact with TRIP6.

Evolution

Paralogues

Source:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
↑ An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
↑ An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.
↑ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
↑ Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.
↑ "GeneCards®: The Human Gene Database".
↑ "Ensembl Genome Browser".

External links

"Lysophospholipid Receptors: LPA₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".

[pmid9525886-6] An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.

[pmid9804623-7] An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID 9804623. S2CID 37327084.

[Choi_2010-8] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[pmid14688263-9] Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.

[10] "GeneCards®: The Human Gene Database".

[11] "Ensembl Genome Browser".