List of Wait Wait... Don't Tell Me! episodes (2021)

The following is a list of episodes of Wait Wait... Don't Tell Me!, NPR's news panel game, that aired during 2021. All episodes, unless otherwise indicated, feature host Peter Sagal and announcer/scorekeeper Bill Kurtis, and are produced through the facilities of Wait Wait co-producer WBEZ/Chicago (participants join the show through remote links). Dates indicated are the episodes' original Saturday air dates. Job titles and backgrounds of the guests reflect their status at the time of their appearance.

• Wait Wait... Don't Tell Me! official website
• WWDT.me, an unofficial Wait Wait historical site