MAX dimerization protein MGA

MGA
Identifiers
Aliases	MGA, MAD5, MXD5, MAX dimerization protein, MAX dimerization protein MGA
External IDs	OMIM: 616061; MGI: 1352483; GeneCards: MGA
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,773,081 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,800,062 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; oocyte; ; tendon of biceps brachii; ; secondary oocyte; ; testicle; ; corpus callosum; ; internal globus pallidus; ; sperm; ; sural nerve; ; pylorus;
	Top expressed in
	genital tubercle; ; tail of embryo; ; pineal gland; ; cumulus cell; ; Gonadal ridge; ; pituitary gland; ; vas deferens; ; ascending aorta; ; lobe of cerebellum; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; protein binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; MLL1 complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of G0 to G1 transition; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23269
	29808
	ENSG00000174197
	ENSMUSG00000033943
	Q8IWI9
	A2AWL7
NM_001080541; NM_001164273; NM_001400225; NM_001400242; NM_001400243;
	NM_001400244; NM_001400245; NM_001400246; NM_001400247
	NM_001164274; NM_013720
	NP_001074010; NP_001157745
	NP_001157746; NP_038748
	Wikidata
View/Edit Human	View/Edit Mouse

MAX dimerization protein MGA is a protein that in humans is encoded by the gene MGA. This protein is a transcription factor with dual-specificity, regulating the expression of both MAX-target and T-box genes.

Medical significance

Pathogenic mutations in MGA are associated with primary amenorrhea or early menopause, which has been designated as premature ovarian failure-26 (POF26). This follows an autosomal dominant pattern of inheritance.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174197 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033943 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MGA, MAX dimerization protein". Retrieved 2018-03-23.
↑ "MAX gene-associated protein". UniProt consortium. Retrieved 2026-10-24.
1 2 O'Neil MJ (2025-01-16). "PREMATURE OVARIAN FAILURE 26; POF26". OMIM. Johns Hopkins university. Retrieved 2026-10-24.

Parsons KS, Hsu AC, Wark PA (January 2014). "TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection". Clin. Exp. Allergy. 44 (1): 91–101. doi:10.1111/cea.12218. PMID 24131248. S2CID 24528615.
Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M (March 2014). "MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1". Cancer Discov. 4 (3): 292–303. doi:10.1158/2159-8290.CD-13-0799. PMID 24362264.
Duan C, Yang X, Zhang X, Feng J, Liu Z, Que H, Johnson H, Zhao Y, Fan Y, Lu Y, Zhang H, Huang Y, Xiu B, Feng X (August 2015). "Generation of monoclonal antibodies against MGA and comparison of their application in breast cancer detection by immunohistochemistry". Sci Rep. 5 13073. Bibcode:2015NatSR...513073D. doi:10.1038/srep13073. PMC 4536492. PMID 26272389.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174197 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033943 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MGA, MAX dimerization protein". Retrieved 2018-03-23.

[6] "MAX gene-associated protein". UniProt consortium. Retrieved 2026-10-24.

[omim-7] 1 2 O'Neil MJ (2025-01-16). "PREMATURE OVARIAN FAILURE 26; POF26". OMIM. Johns Hopkins university. Retrieved 2026-10-24.

MAX dimerization protein MGA

Medical significance

References

Further reading