Proline–tRNA ligase

Proline–tRNA ligase
Identifiers
EC no.6.1.1.15
CAS no.9055-68-9
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a proline–tRNA ligase or proline—tRNA ligase (accepted enzyme name) is an enzyme that catalyzes the chemical reaction

ATP + L-proline + tRNAPro AMP + diphosphate + L-prolyl-tRNAPro

The 3 substrates of this enzyme are ATP, L-proline, and tRNAPro, whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNAPro.

This enzyme participates in arginine and proline metabolism and aminoacyl-tRNA biosynthesis.

Nomenclature

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-proline:tRNAPro ligase (AMP-forming). Other names in common use include prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, and prolinyl-tRNA ligase.

References

  1. ↑ "EC 6.1.1.15". iubmb.qmul.ac.uk. Retrieved 2026-09-05.

Further reading