Propanediol dehydratase

propanediol dehydratase
Identifiers
EC no.4.2.1.28
CAS no.9026-90-8
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme propanediol dehydratase (EC 4.2.1.28) catalyzes the chemical reaction

propane-1,2-diol propanal + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, DL-1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B12-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1DIO​, PDB: 1EEX​, PDB: 1EGM​, PDB: 1EGV​, PDB: 1IWB​, PDB: 1UC4​, and PDB: 1UC5​.

References