RLE

RLE may refer to:

• Run-length encoding, a form of lossless data compression
• Radical life extension, a study to extend human lifespan
• Right-to-left embedding, in bi-directional text
• Refractive lens exchange, an eye operation
• Real-life experience (transgender), a period of time in which transgender individuals live full-time in their preferred gender role
• Rail Logistics Europe, the rail freight and logistics operations division of SNCF