SAM domain, SH3 domain and nuclear localization signals 1

SAMSN1
Identifiers
Aliases	SAMSN1, HACS1, NASH1, SASH2, SH3D6B, SLy2, SAM domain, SH3 domain and nuclear localization signals 1
External IDs	OMIM: 607978; MGI: 1914992; GeneCards: SAMSN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KEA
Gene location (Human)
Chr.	Chromosome 21 (human)
End	14,658,821 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	75,819,169 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; appendix; ; bone marrow cell; ; monocyte; ; right lung; ; blood; ; spleen; ; lymph node; ; epithelium of nasopharynx; ; trabecular bone;
	Top expressed in
	granulocyte; ; lumbar spinal ganglion; ; mesenteric lymph nodes; ; neural layer of retina; ; spleen; ; bone marrow; ; blood; ; thymus; ; tibiofemoral joint; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphotyrosine residue binding; RNA binding;
Cellular component	cytoplasm; ruffle; cytosol; cell projection; nucleus; plasma membrane;
Biological process	negative regulation of B cell activation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64092
	67742
	ENSG00000155307
	ENSMUSG00000022876
	Q9NSI8
	P57725
	NM_001256370; NM_001286523; NM_022136
	NM_023380
	NP_001243299; NP_001273452; NP_071419
	NP_075869
	Wikidata
View/Edit Human	View/Edit Mouse

SAM domain-containing protein SAMSN-1 is a protein that in humans is encoded by the SAMSN1 gene.

Function

SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000155307 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022876 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SAM domain, SH3 domain and nuclear localization signals 1". Retrieved 2017-09-28.

Zhu YX, Benn S, Li ZH, Wei E, Masih-Khan E, Trieu Y, Bali M, McGlade CJ, Claudio JO, Stewart AK (2004). "The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades". J. Exp. Med. 200 (6): 737–47. doi:10.1084/jem.20031816. PMC 2211965. PMID 15381729.
Yamada H, Yanagisawa K, Tokumaru S, Taguchi A, Nimura Y, Osada H, Nagino M, Takahashi T (2008). "Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer". Genes Chromosomes Cancer. 47 (9): 810–8. doi:10.1002/gcc.20582. PMID 18523997. S2CID 39369334.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Brandt S, Ellwanger K, Beuter-Gunia C, Schuster M, Hausser A, Schmitz I, Beer-Hammer S (2010). "SLy2 targets the nuclear SAP30/HDAC1 complex". Int. J. Biochem. Cell Biol. 42 (9): 1472–81. doi:10.1016/j.biocel.2010.05.004. PMID 20478393.
von Holleben M, Gohla A, Janssen KP, Iritani BM, Beer-Hammer S (2011). "Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading". J. Biol. Chem. 286 (15): 13489–501. doi:10.1074/jbc.M110.155184. PMC 3075695. PMID 21296879.
Yan Y, Zhang L, Xu T, Zhou J, Qin R, Chen C, Zou Y, Fu D, Hu G, Chen J, Lu Y (2013). "SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme". PLOS ONE. 8 (11) e81905. Bibcode:2013PLoSO...881905Y. doi:10.1371/journal.pone.0081905. PMC 3838348. PMID 24278465.
Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC (2014). "SAMSN1 is a tumor suppressor gene in multiple myeloma". Neoplasia. 16 (7): 572–85. doi:10.1016/j.neo.2014.07.002. PMC 4198825. PMID 25117979.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000155307 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022876 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SAM domain, SH3 domain and nuclear localization signals 1". Retrieved 2017-09-28.

SAM domain, SH3 domain and nuclear localization signals 1

Function

See also

References

Further reading