SELENOS

SELENOS
Identifiers
Aliases	SELENOS, ADO15, SBBI8, SELS, SEPS1, AD-015, VIMP, VCP interacting membrane selenoprotein, selenoprotein S
External IDs	OMIM: 607918; MGI: 95994; GeneCards: SELENOS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Q2F
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,277,500 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,739,153 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; skin of arm; ; myocardium of left ventricle; ; mucosa of sigmoid colon; ; jejunal mucosa; ; cartilage tissue; ; tibialis anterior muscle; ; parotid gland; ; rectum; ; duodenum;
	Top expressed in
	lacrimal gland; ; seminal vesicula; ; Epithelium of choroid plexus; ; Paneth cell; ; conjunctival fornix; ; salivary gland; ; utricle; ; crypt of lieberkuhn of small intestine; ; parotid gland; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; antioxidant activity; protein binding; enzyme binding; ubiquitin-specific protease binding; signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; Derlin-1-VIMP complex; plasma membrane; very-low-density lipoprotein particle; integral component of endoplasmic reticulum membrane; endoplasmic reticulum; low-density lipoprotein particle; Derlin-1 retrotranslocation complex; cytoplasmic microtubule; endoplasmic reticulum membrane;
Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; regulation of gluconeogenesis; establishment of protein localization; negative regulation of interleukin-6 production; response to glucose; negative regulation of glycogen biosynthetic process; cell redox homeostasis; ER overload response; response to redox state; endoplasmic reticulum unfolded protein response; negative regulation of glucose import; retrograde protein transport, ER to cytosol; negative regulation of macrophage apoptotic process; ubiquitin-dependent ERAD pathway; cellular response to insulin stimulus; regulation of nitric oxide metabolic process; cellular response to oxidative stress; negative regulation of tumor necrosis factor production; negative regulation of acute inflammatory response to antigenic stimulus; cellular response to lipopolysaccharide; intracellular protein transport; negative regulation of inflammatory response; negative regulation of nitric-oxide synthase biosynthetic process; cellular oxidant detoxification; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55829
	109815
	ENSG00000131871
	ENSMUSG00000075701
	Q9BQE4
	Q9BCZ4
	NM_203472; NM_018445
	NM_024439; NM_001348246
	NP_060915; NP_982298
	NP_001335175; NP_077759
	Wikidata
View/Edit Human	View/Edit Mouse

Selenoprotein S is a protein that in humans is encoded by the gene SELENOS (previously SELS).

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions

SELS (gene) has been shown to interact with Valosin-containing protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131871 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075701 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: SELS selenoprotein S".
↑ Ye, Yihong; Shibata Yoko; Yun Chi; Ron David; Rapoport Tom A (Jun 2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. 429 (6994): 841–847. Bibcode:2004Natur.429..841Y. doi:10.1038/nature02656. PMID 15215856. S2CID 4317750.
↑ Wang, Qiuyan; Li Lianyun; Ye Yihong (Mar 2008). "Inhibition of p97-dependent Protein Degradation by Eeyarestatin I". J. Biol. Chem. 283 (12): 7445–7454. doi:10.1074/jbc.M708347200. ISSN 0021-9258. PMC 2276333. PMID 18199748.

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl:10669/15162. PMID 7829101.
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Bonaldo MF; Lennon G; Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Walder K, Kantham L, McMillan JS, et al. (2002). "Tanis: a link between type 2 diabetes and inflammation?". Diabetes. 51 (6): 1859–1866. doi:10.2337/diabetes.51.6.1859. PMID 12031974.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gao Y, Walder K, Sunderland T, et al. (2003). "Elevation in Tanis expression alters glucose metabolism and insulin sensitivity in H4IIE cells". Diabetes. 52 (4): 929–934. doi:10.2337/diabetes.52.4.929. PMID 12663463.
Kryukov GV, Castellano S, Novoselov SV, et al. (2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–1443. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gao Y, Feng HC, Walder K, et al. (2004). "Regulation of the selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein". FEBS Lett. 563 (1–3): 185–190. Bibcode:2004FEBSL.563..185G. doi:10.1016/S0014-5793(04)00296-0. hdl:10536/DRO/DU:30002457. PMID 15063746. S2CID 45977972.
Karlsson HK, Tsuchida H, Lake S, et al. (2004). "Relationship between serum amyloid A level and Tanis/SelS mRNA expression in skeletal muscle and adipose tissue from healthy and type 2 diabetic subjects". Diabetes. 53 (6): 1424–1428. doi:10.2337/diabetes.53.6.1424. PMID 15161744.
Ye Y, Shibata Y, Yun C, et al. (2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. 429 (6994): 841–847. Bibcode:2004Natur.429..841Y. doi:10.1038/nature02656. PMID 15215856. S2CID 4317750.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lilley BN; Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–14301. doi:10.1073/pnas.0505014102. PMC 1242303. PMID 16186509.
Ye Y, Shibata Y, Kikkert M, et al. (2006). "Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14132–14138. doi:10.1073/pnas.0505006102. PMC 1242302. PMID 16186510.
Curran JE, Jowett JB, Elliott KS, et al. (2006). "Genetic variation in selenoprotein S influences inflammatory response". Nat. Genet. 37 (11): 1234–1241. doi:10.1038/ng1655. hdl:10536/DRO/DU:30006596. PMID 16227999. S2CID 19184873.
Gao Y, Hannan NR, Wanyonyi S, et al. (2006). "Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells". Cytokine. 33 (5): 246–251. doi:10.1016/j.cyto.2006.02.005. PMID 16574427.
Gao Y, Pagnon J, Feng HC, et al. (2007). "Secretion of the glucose-regulated selenoprotein SEPS1 from hepatoma cells". Biochem. Biophys. Res. Commun. 356 (3): 636–641. Bibcode:2007BBRC..356..636G. doi:10.1016/j.bbrc.2007.03.018. PMID 17374524.
Seiderer J, Dambacher J, Kühnlein B, et al. (2007). "The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation". Tissue Antigens. 70 (3): 238–246. doi:10.1111/j.1399-0039.2007.00888.x. PMID 17661913.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131871 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075701 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: SELS selenoprotein S".

[pmid15215856-6] Ye, Yihong; Shibata Yoko; Yun Chi; Ron David; Rapoport Tom A (Jun 2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. 429 (6994): 841–847. Bibcode:2004Natur.429..841Y. doi:10.1038/nature02656. PMID 15215856. S2CID 4317750.

[pmid18199748-7] Wang, Qiuyan; Li Lianyun; Ye Yihong (Mar 2008). "Inhibition of p97-dependent Protein Degradation by Eeyarestatin I". J. Biol. Chem. 283 (12): 7445–7454. doi:10.1074/jbc.M708347200. ISSN 0021-9258. PMC 2276333. PMID 18199748.

SELENOS

Interactions

References

Further reading