TAC3

TAC3
Identifiers
Aliases	TAC3, HH10, NKB, NKNB, PRO1155, ZNEUROK1, tachykinin 3, tachykinin precursor 3, NK3, LncZBTB39, preprotachykinin-B
External IDs	OMIM: 162330; MGI: 98476; GeneCards: TAC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P9F
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,028,883 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,567,637 bp
RNA expression pattern
	Top expressed in
	decidua; ; gonad; ; anterior cingulate cortex; ; caudate nucleus; ; prefrontal cortex; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; right frontal lobe; ; putamen; ; testicle;
	Top expressed in
	gastrula; ; habenula; ; lumbar subsegment of spinal cord; ; lateral hypothalamus; ; zygote; ; neural layer of retina; ; arcuate nucleus; ; nucleus of stria terminalis; ; secondary oocyte; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; neuromedin K receptor binding; substance K receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	female pregnancy; neuropeptide signaling pathway; tachykinin receptor signaling pathway; positive regulation of flagellated sperm motility; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6866
	21334
	ENSG00000166863
	ENSMUSG00000025400
	Q9UHF0
	P55099
	NM_001006667; NM_001178054; NM_013251
	NM_001199971; NM_009312
	NP_001171525; NP_037383
	NP_001186900; NP_033338
	Wikidata
View/Edit Human	View/Edit Mouse

Tachykinin-3, also called tachykinin precursor 3, is a protein that in humans is encoded by the TAC3 gene. This is a precursor protein that is cleaved by enzymes to produce the active hormone neurokinin B. In particular, neurokinin B corresponds to a subchain of positions 81-90 out of the 121 amino acids of the full precursor molecule.

Naming issues

In certain non-human animals, like mice, this gene has been inconsistently designated as either Tac2 or Tac3 by different naming authorities. In humans on the other hand, TAC2 has previously been used to mean TAC1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166863 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025400 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. doi:10.1016/0169-328x(87)90031-3. PMID 3479225.
↑ Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. Bibcode:2000Natur.405..797P. doi:10.1038/35015579. PMID 10866201. S2CID 4392048.
1 2 "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".
↑ "Tachykinin-3". UniProt consortium. Retrieved 2026-10-14.
↑ "Tac2 tachykinin 2 [ Mus musculus (house mouse) ]". Retrieved 2026-10-14.
↑ "P55099 · TKNK_MOUSE". UniProt consortium. Retrieved 2026-10-14.
↑ "Symbol report for TAC1". HGNC. Retrieved 2026-10-14.

Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia". Regul. Pept. 98 (3): 97–104. doi:10.1016/S0167-0115(00)00239-1. PMID 11231038. S2CID 7160887.
Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women". Endocrinology. 128 (5): 2239–47. doi:10.1210/endo-128-5-2239. PMID 1708331.
Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor". J. Biol. Chem. 269 (44): 27269–74. doi:10.1016/S0021-9258(18)46979-7. PMID 7961636.
Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity". J. Biol. Chem. 271 (34): 20250–7. doi:10.1074/jbc.271.34.20250. PMID 8702757.
Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds 3Hsenktide and 125I-MePhe7neurokinin B, and is responsive to tachykinin peptide agonists". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310–5. doi:10.1073/pnas.94.1.310. PMC 19326. PMID 8990205.
Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis". Neuropeptides. 32 (3): 215–23. doi:10.1016/S0143-4179(98)90040-3. PMID 10189055. S2CID 40222022.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brownbill P, Bell NJ, Woods RJ, et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation". J. Clin. Endocrinol. Metab. 88 (5): 2164–70. doi:10.1210/jc.2002-021727. PMID 12727971.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Schlembach D, Scalera F, Fischer T, et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women". Am. J. Obstet. Gynecol. 189 (5): 1418–22. doi:10.1067/S0002-9378(03)00775-0. PMID 14634580.
Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels". Regul. Pept. 117 (2): 123–6. doi:10.1016/j.regpep.2003.10.032. PMID 14700748. S2CID 25577867.
Pal S, Nemeth MJ, Bodine D, et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1". J. Biol. Chem. 279 (30): 31348–56. doi:10.1074/jbc.M403475200. PMID 15123623.
Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles". J. Biomol. Struct. Dyn. 22 (2): 137–48. doi:10.1080/07391102.2004.10506990. PMID 15317475. S2CID 41064499.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia". Mol. Hum. Reprod. 12 (7): 427–33. doi:10.1093/molehr/gal025. PMID 16709596.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166863 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025400 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3479225-5] Bonner TI, Affolter HU, Young AC, Young WS (Jan 1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B". Brain Res. 388 (3): 243–9. doi:10.1016/0169-328x(87)90031-3. PMID 3479225.

[pmid10866201-6] Page NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ (Jul 2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia". Nature. 405 (6788): 797–800. Bibcode:2000Natur.405..797P. doi:10.1038/35015579. PMID 10866201. S2CID 4392048.

[entrez-7] 1 2 "Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta)".

[8] "Tachykinin-3". UniProt consortium. Retrieved 2026-10-14.

[9] "Tac2 tachykinin 2 [ Mus musculus (house mouse) ]". Retrieved 2026-10-14.

[10] "P55099 · TKNK_MOUSE". UniProt consortium. Retrieved 2026-10-14.

[11] "Symbol report for TAC1". HGNC. Retrieved 2026-10-14.

TAC3

Naming issues

See also

References

Further reading