Trichodiene synthase

The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1YJ4​, PDB: 1YYQ​, PDB: 1YYR​, PDB: 1YYS​, PDB: 1YYT​, PDB: 1YYU​, PDB: 2AEK​, PDB: 2AEL​, and PDB: 2AET​.

References

• Hohn TM, Vanmiddlesworth F (1986). "Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides". Arch. Biochem. Biophys. 251 (2): 756–61. doi:10.1016/0003-9861(86)90386-3. PMID 3800398.^{[dead link]}

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