USS Guadalupe may refer to the following ships of the United States Navy:
- USS Guadalupe (AO-32), a United States Navy replenishment oiler in commission from 1941 to 1974
- USNS Guadalupe (T-AO-200), a United States Navy fleet replenishment oiler in service since 1992
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.