Barakol

Barakol
Clinical data
ATC code
  • none
Identifiers
  • 2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H12O4
Molar mass232.235 g·mol−1
3D model (JSmol)
  • CC2=Cc3cc(O)cc(c13)OC(C)=CC1(O)O2
  • InChI=1S/C13H12O4/c1-7-3-9-4-10(14)5-11-12(9)13(15,17-7)6-8(2)16-11/h3-6,14-15H,1-2H3 checkY
  • Key:LVPNMZHEDIKUFK-UHFFFAOYSA-N checkY
 X markNcheckY (what is this?)  (verify)

Barakol is a compound found in the plant Senna siamea, which is used in traditional herbal medicine. It has sedative and anxiolytic effects. There are contradictory pharmacological research findings concerning the toxicity of Senna siamea and the active ingredient barakol. One pharmacological study has shown an hepatoxic effect of barakol, while another study did not show any toxic effect at a daily dosage intake. Further research is needed to verify whether there are toxic effects of barakol or not.

References

  1. ↑ Padumanonda T, Gritsanapan W (March 2006). "Barakol contents in fresh and cooked Senna siamea leaves". The Southeast Asian Journal of Tropical Medicine and Public Health. 37 (2): 388–93. PMID 17125004.
  2. ↑ Thongsaard W, Pongsakorn S, Sudsuang R, Bennett GW, Kendall DA, Marsden CA (January 1997). "Barakol, a natural anxiolytic, inhibits striatal dopamine release but off uptake in vitro". European Journal of Pharmacology. 319 (2–3): 157–64. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586.
  3. ↑ Sukma M, Chaichantipyuth C, Murakami Y, Tohda M, Matsumoto K, Watanabe H (November 2002). "CNS inhibitory effects of barakol, a constituent of Cassia siamia Lamk". Journal of Ethnopharmacology. 83 (1–2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711.
  4. ↑ Hongsirinirachorn M, Threeprasertsuk S, Chutaputti A (June 2003). "Acute hepatitis associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 (Suppl 2): S484-9. PMID 12930029.
  5. ↑ Wahjoedi B, Pudjiastuti P, Nuratmi B, Sundari D, Chozin A (December 1999). "Toksisitas Subkronik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih [The subchronic toxicity study of the ethanolic extract of Cassia siamea lamk leaf (daun johar) on albino rats]". Bulletin of Health Research = Buletin Penelitian Kesehatan = National Institute of Health Research and Development - Ministry of Health of Republic of Indonesia. 27 Suppl. 3 & 4: S325–332.