Ciclina D1

Ciclina D1
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	CCND1 (HGNC: 1582) BCL1; D11S287E; PRAD1; U21B31
Identificadores; externos	OMIM: 168461 ; EBI: CCND1; GeneCards: Gen CCND1; UniProt: CCND1;
Locus	Cr. 11 q13.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
595
P24385	n/a
NP_444284	n/a
	[editar datos en Wikidata]

La ciclina D1 específica de G1/S es una proteína que es codificada en humanos por el gen CCND1.

Esta proteína pertenece a una familia de ciclinas muy conservadas, cuyos miembros se caracterizan por incrementar drásticamente y a intervalos su concentración a lo largo del ciclo celular. Las ciclinas funcionan como reguladores de las quinasas dependientes de ciclinas o Cdks. Diferentes ciclinas muestran patrones de expresión y de degradación que contribuyen a la coordinación temporal de cada evento de la mitosis. La ciclina D1 actúa como subunidad reguladora de un complejo formado con Cdk4 o Cdk6 y su actividad es necesaria para la transición G1/S del ciclo celular. Además, esta proteína también ha demostrado ser capaz de interaccionar con Rb, que es capaz de regular positivamente la expresión de la ciclina D1. Se han observado mutaciones, amplificaciones y sobre-expresiones de este gen que alteran la progresión del ciclo celular, en diversos tipos de tumores, con lo que podría contribuir en el proceso de tumorigénesis.

Interacciones

La ciclina D1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

↑ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A (mayo de 1991). «A novel cyclin encoded by a bcl1-linked candidate oncogene». Nature 350 (6318): 512-5. PMID 1826542. doi:10.1038/350512a0.
↑ Lew DJ, Dulic V, Reed SI (Oct de 1991). «Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast». Cell 66 (6): 1197-206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.
↑ «Entrez Gene: CCND1 cyclin D1».
1 2 Lin, Huei-Min; Zhao Li, Cheng Sheue-Yann (Aug. de 2002). «Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors». J. Biol. Chem. (United States) 277 (32): 28733-41. ISSN 0021-9258. PMID 12048199. doi:10.1074/jbc.M203380200.
↑ Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul. de 2000). «GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity». J. Biol. Chem. (UNITED STATES) 275 (27): 20942-8. ISSN 0021-9258. PMID 10801854. doi:10.1074/jbc.M002598200.
1 2 Siegert, J L; Rushton J J, Sellers W R, Kaelin W G, Robbins P D (Nov. de 2000). «Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity». Oncogene (England) 19 (50): 5703-11. ISSN 0950-9232. PMID 11126356. doi:10.1038/sj.onc.1203966.
↑ Dowdy, S F; Hinds P W, Louie K, Reed S I, Arnold A, Weinberg R A (mayo. de 1993). «Physical interaction of the retinoblastoma protein with human D cyclins». Cell (UNITED STATES) 73 (3): 499-511. ISSN 0092-8674. PMID 8490963. doi:10.1016/0092-8674(93)90137-F.
1 2 Petre-Draviam, Christin E; Williams Erin B, Burd Craig J, Gladden Andrew, Moghadam Hamed, Meller Jaroslaw, Diehl J Alan, Knudsen Karen E (Jan. de 2005). «A central domain of cyclin D1 mediates nuclear receptor corepressor activity». Oncogene (England) 24 (3): 431-44. ISSN 0950-9232. PMID 15558026. doi:10.1038/sj.onc.1208200.
↑ Knudsen, K E; Cavenee W K, Arden K C (mayo. de 1999). «D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability». Cancer Res. (UNITED STATES) 59 (10): 2297-301. ISSN 0008-5472. PMID 10344732.
1 2 Sugimoto, M; Nakamura T, Ohtani N, Hampson L, Hampson I N, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Nov. de 1999). «Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)». Genes Dev. (UNITED STATES) 13 (22): 3027-33. ISSN 0890-9369. PMC 317153. PMID 10580009. doi:10.1101/gad.13.22.3027.
↑ Serrano, M; Hannon G J, Beach D (Dec. de 1993). «A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4». Nature (ENGLAND) 366 (6456): 704-7. ISSN 0028-0836. PMID 8259215. doi:10.1038/366704a0.
1 2 Lin, J; Jinno S; Okayama H (Apr. de 2001). «Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence». Oncogene (England) 20 (16): 2000-9. ISSN 0950-9232. PMID 11360184. doi:10.1038/sj.onc.1204375.
↑ Taulés, M; Rius E, Talaya D, López-Girona A, Bachs O, Agell N (Dec. de 1998). «Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1». J. Biol. Chem. (UNITED STATES) 273 (50): 33279-86. ISSN 0021-9258. PMID 9837900. doi:10.1074/jbc.273.50.33279.
↑ Cariou, S; Donovan J C, Flanagan W M, Milic A, Bhattacharya N, Slingerland J M (Aug. de 2000). «Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9042-6. ISSN 0027-8424. PMC 16818. PMID 10908655. doi:10.1073/pnas.160016897.
↑ Coleman, K G; Wautlet B S, Morrissey D, Mulheron J, Sedman S A, Brinkley P, Price S, Webster K R (Jul. de 1997). «Identification of CDK4 sequences involved in cyclin D1 and p16 binding». J. Biol. Chem. (UNITED STATES) 272 (30): 18869-74. ISSN 0021-9258. PMID 9228064. doi:10.1074/jbc.272.30.18869.
↑ Adnane, J; Shao Z, Robbins P D (Jan. de 1999). «Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription». Oncogene (ENGLAND) 18 (1): 239-47. ISSN 0950-9232. PMID 9926939. doi:10.1038/sj.onc.1202297.
↑ Ratineau, Christelle; Petry Mary W, Mutoh Hiroyuki, Leiter Andrew B (Mar. de 2002). «Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD». J. Biol. Chem. (United States) 277 (11): 8847-53. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200.
↑ Matsuoka, S; Yamaguchi M; Matsukage A (Apr. de 1994). «D-type cyclin-binding regions of proliferating cell nuclear antigen». J. Biol. Chem. (UNITED STATES) 269 (15): 11030-6. ISSN 0021-9258. PMID 7908906.
↑ Xiong, Y; Zhang H; Beach D (Aug. de 1993). «Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation». Genes Dev. (UNITED STATES) 7 (8): 1572-83. ISSN 0890-9369. PMID 8101826. doi:10.1101/gad.7.8.1572.
↑ Zwijsen, R M; Buckle R S, Hijmans E M, Loomans C J, Bernards R (Nov. de 1998). «Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1». Genes Dev. (UNITED STATES) 12 (22): 3488-98. ISSN 0890-9369. PMC 317237. PMID 9832502. doi:10.1101/gad.12.22.3488.
↑ Zwijsen, R M; Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides R J (Feb. de 1997). «CDK-independent activation of estrogen receptor by cyclin D1». Cell (UNITED STATES) 88 (3): 405-15. ISSN 0092-8674. PMID 9039267. doi:10.1016/S0092-8674(00)81879-6.

Datos: Q15311861

[pmid1826542-1] Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A (mayo de 1991). «A novel cyclin encoded by a bcl1-linked candidate oncogene». Nature 350 (6318): 512-5. PMID 1826542. doi:10.1038/350512a0.

[pmid1833066-2] Lew DJ, Dulic V, Reed SI (Oct de 1991). «Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast». Cell 66 (6): 1197-206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.

[entrez-3] «Entrez Gene: CCND1 cyclin D1».

[pmid12048199-4] 1 2 Lin, Huei-Min; Zhao Li, Cheng Sheue-Yann (Aug. de 2002). «Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors». J. Biol. Chem. (United States) 277 (32): 28733-41. ISSN 0021-9258. PMID 12048199. doi:10.1074/jbc.M203380200.

[pmid10801854-5] Xia, C; Bao Z; Tabassam F; Ma W; Qiu M; Hua S; Liu M (Jul. de 2000). «GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity». J. Biol. Chem. (UNITED STATES) 275 (27): 20942-8. ISSN 0021-9258. PMID 10801854. doi:10.1074/jbc.M002598200.

[pmid11126356-6] 1 2 Siegert, J L; Rushton J J, Sellers W R, Kaelin W G, Robbins P D (Nov. de 2000). «Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity». Oncogene (England) 19 (50): 5703-11. ISSN 0950-9232. PMID 11126356. doi:10.1038/sj.onc.1203966.

[pmid8490963-7] Dowdy, S F; Hinds P W, Louie K, Reed S I, Arnold A, Weinberg R A (mayo. de 1993). «Physical interaction of the retinoblastoma protein with human D cyclins». Cell (UNITED STATES) 73 (3): 499-511. ISSN 0092-8674. PMID 8490963. doi:10.1016/0092-8674(93)90137-F.

[pmid15558026-8] 1 2 Petre-Draviam, Christin E; Williams Erin B, Burd Craig J, Gladden Andrew, Moghadam Hamed, Meller Jaroslaw, Diehl J Alan, Knudsen Karen E (Jan. de 2005). «A central domain of cyclin D1 mediates nuclear receptor corepressor activity». Oncogene (England) 24 (3): 431-44. ISSN 0950-9232. PMID 15558026. doi:10.1038/sj.onc.1208200.

[pmid10344732-9] Knudsen, K E; Cavenee W K, Arden K C (mayo. de 1999). «D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability». Cancer Res. (UNITED STATES) 59 (10): 2297-301. ISSN 0008-5472. PMID 10344732.

[pmid10580009-10] 1 2 Sugimoto, M; Nakamura T, Ohtani N, Hampson L, Hampson I N, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Nov. de 1999). «Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)». Genes Dev. (UNITED STATES) 13 (22): 3027-33. ISSN 0890-9369. PMC 317153. PMID 10580009. doi:10.1101/gad.13.22.3027.

[pmid8259215-11] Serrano, M; Hannon G J, Beach D (Dec. de 1993). «A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4». Nature (ENGLAND) 366 (6456): 704-7. ISSN 0028-0836. PMID 8259215. doi:10.1038/366704a0.

[pmid11360184-12] 1 2 Lin, J; Jinno S; Okayama H (Apr. de 2001). «Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence». Oncogene (England) 20 (16): 2000-9. ISSN 0950-9232. PMID 11360184. doi:10.1038/sj.onc.1204375.

[pmid9837900-13] Taulés, M; Rius E, Talaya D, López-Girona A, Bachs O, Agell N (Dec. de 1998). «Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1». J. Biol. Chem. (UNITED STATES) 273 (50): 33279-86. ISSN 0021-9258. PMID 9837900. doi:10.1074/jbc.273.50.33279.

[pmid10908655-14] Cariou, S; Donovan J C, Flanagan W M, Milic A, Bhattacharya N, Slingerland J M (Aug. de 2000). «Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9042-6. ISSN 0027-8424. PMC 16818. PMID 10908655. doi:10.1073/pnas.160016897.

[pmid9228064-15] Coleman, K G; Wautlet B S, Morrissey D, Mulheron J, Sedman S A, Brinkley P, Price S, Webster K R (Jul. de 1997). «Identification of CDK4 sequences involved in cyclin D1 and p16 binding». J. Biol. Chem. (UNITED STATES) 272 (30): 18869-74. ISSN 0021-9258. PMID 9228064. doi:10.1074/jbc.272.30.18869.

[pmid9926939-16] Adnane, J; Shao Z, Robbins P D (Jan. de 1999). «Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription». Oncogene (ENGLAND) 18 (1): 239-47. ISSN 0950-9232. PMID 9926939. doi:10.1038/sj.onc.1202297.

[pmid11788592-17] Ratineau, Christelle; Petry Mary W, Mutoh Hiroyuki, Leiter Andrew B (Mar. de 2002). «Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD». J. Biol. Chem. (United States) 277 (11): 8847-53. ISSN 0021-9258. PMID 11788592. doi:10.1074/jbc.M110747200.

[pmid7908906-18] Matsuoka, S; Yamaguchi M; Matsukage A (Apr. de 1994). «D-type cyclin-binding regions of proliferating cell nuclear antigen». J. Biol. Chem. (UNITED STATES) 269 (15): 11030-6. ISSN 0021-9258. PMID 7908906.

[pmid8101826-19] Xiong, Y; Zhang H; Beach D (Aug. de 1993). «Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation». Genes Dev. (UNITED STATES) 7 (8): 1572-83. ISSN 0890-9369. PMID 8101826. doi:10.1101/gad.7.8.1572.

[pmid9832502-20] Zwijsen, R M; Buckle R S, Hijmans E M, Loomans C J, Bernards R (Nov. de 1998). «Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1». Genes Dev. (UNITED STATES) 12 (22): 3488-98. ISSN 0890-9369. PMC 317237. PMID 9832502. doi:10.1101/gad.12.22.3488.

[pmid9039267-21] Zwijsen, R M; Wientjens E, Klompmaker R, van der Sman J, Bernards R, Michalides R J (Feb. de 1997). «CDK-independent activation of estrogen receptor by cyclin D1». Cell (UNITED STATES) 88 (3): 405-15. ISSN 0092-8674. PMID 9039267. doi:10.1016/S0092-8674(00)81879-6.