CDH1

Cadherina 1

Estructura tridimensional de la proteína CDH1.
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Lista de códigos PDB
1i7w
Identificadores
Símbolos CDH1 (HGNC: 1748) Arc-1; CD324; CDHE; ECAD; LCAM; UVO
Identificadores
externos
  • GeneCards: Gen CDH1
  • UniProt: CDH1
    • Locus Cr. 16 q22.1
    Ortólogos
    Especies
    Humano Ratón
    Entrez
    999
    UniProt
    P12830 n/a
    RefSeq
    (ARNm)
    NP_004351 n/a
    [editar datos en Wikidata]

    La cadherina 1 (CDH1 o CD324) es una proteína codificada en humanos por el gen CDH1.

    CDH1 es un gen supresor de tumores. La proteína CDH1 es una cadherina clásica perteneciente a la familia de las cadherinas. Esta proteína es una glicoproteína de adhesión célula-célula dependiente de calcio, compuesta de cinco repeticiones tipo cadherina extracelulares, una región transmembranal y un extremo citoplásmico altamente conservado. Se han asociado mutaciones del gen CHD1 con diversos tipos de cáncer (gástrico, de pecho, colorrectal, tiroideo y ovárico). La pérdida de función parece contribuir a la progresión del cáncer por un incremento de la proliferación celular, de la invasión y de la metástasis. El ectodominio de esta proteína media en la adhesión bacteriana a las células de mamíferos, y el dominio citoplásmico es necesario para que se produzca la internalización. Se han descrito diversas variantes transcripcionales por mutación de los sitios de splicing alternativo.

    Interacciones

    La proteína CDH1 ha demostrado ser capaz de interaccionar con:

    Véase también

    Referencias

    1. ↑ Huntsman DG, Caldas C (Mar de 1999). «Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping». Cytogenet Cell Genet 83 (1-2): 82-3. PMID 9925936.
    2. ↑ Semb H, Christofori G (diciembre de 1998). «The tumor-suppressor function of E-cadherin». Am. J. Hum. Genet. 63 (6): 1588-93. PMC 1377629. PMID 9837810. doi:10.1086/302173.
    3. ↑ Wong AS, Gumbiner BM (junio de 2003). «Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin». J. Cell Biol. 161 (6): 1191-203. PMC 2173007. PMID 12810698. doi:10.1083/jcb.200212033.
    4. ↑ «Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)».
    5. 1 2 Davies, G; Jiang W G, Mason M D (Apr. de 2001). «HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells». Int. J. Mol. Med. (Greece) 7 (4): 385-8. ISSN 1107-3756. PMID 11254878.
    6. ↑ Kucerová, D; Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (Dec. de 2001). «Expression and interaction of different catenins in colorectal carcinoma cells». Int. J. Mol. Med. (Greece) 8 (6): 695-8. ISSN 1107-3756. PMID 11712088.
    7. ↑ Oyama, T; Kanai Y; Ochiai A; Akimoto S; Oda T; Yanagihara K; Nagafuchi A; Tsukita S; Shibamoto S; Ito F (Dec. de 1994). «A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines». Cancer Res. (UNITED STATES) 54 (23): 6282-7. ISSN 0008-5472. PMID 7954478.
    8. 1 2 Hazan, R B; Kang L, Roe S, Borgen P I, Rimm D L (Dec. de 1997). «Vinculin is associated with the E-cadherin adhesion complex». J. Biol. Chem. (UNITED STATES) 272 (51): 32448-53. ISSN 0021-9258. PMID 9405455.
    9. 1 2 3 4 Kinch, M S; Clark G J, Der C J, Burridge K (Jul. de 1995). «Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia». J. Cell Biol. (UNITED STATES) 130 (2): 461-71. ISSN 0021-9525. PMID 7542250.
    10. ↑ Jiang, Ming-Chung; Liao Ching-Fong, Tai Chia-Chen (Jun. de 2002). «CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells». Biochem. Biophys. Res. Commun. (United States) 294 (4): 900-5. ISSN 0006-291X. PMID 12061792. doi:10.1016/S0006-291X(02)00551-X.
    11. 1 2 3 4 Hazan, R B; Norton L (Apr. de 1998). «The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton». J. Biol. Chem. (UNITED STATES) 273 (15): 9078-84. ISSN 0021-9258. PMID 9535896.
    12. ↑ Bonvini, P; An W G, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, Dunach M, Neckers L M (Feb. de 2001). «Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription». Cancer Res. (United States) 61 (4): 1671-7. ISSN 0008-5472. PMID 11245482.
    13. ↑ Li, Y; Bharti A; Chen D; Gong J; Kufe D (Dec. de 1998). «Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7216-24. ISSN 0270-7306. PMID 9819408.
    14. ↑ Wendeler, M W; Praus M; Jung R; Hecking M; Metzig C; Gessner R (Apr. de 2004). «Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin». Exp. Cell Res. (United States) 294 (2): 345-55. ISSN 0014-4827. PMID 15023525. doi:10.1016/j.yexcr.2003.11.022.
    15. ↑ Shibata, Tatsuhiro; Chuma Makoto, Kokubu Akiko, Sakamoto Michiie, Hirohashi Setsuo (Jul. de 2003). «EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma». Hepatology (United States) 38 (1): 178-86. ISSN 0270-9139. PMID 12830000. doi:10.1053/jhep.2003.50270.
    16. 1 2 3 Piedra, Jose; Miravet Susana, Castaño Julio, Pálmer Héctor G, Heisterkamp Nora, García de Herreros Antonio, Duñach Mireia (Apr. de 2003). «p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction». Mol. Cell. Biol. (United States) 23 (7): 2287-97. ISSN 0270-7306. PMID 12640114.
    17. 1 2 Kang, Jong-Sun; Feinleib Jessica L, Knox Sarah, Ketteringham Michael A, Krauss Robert S (Apr. de 2003). «Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation». Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (7): 3989-94. ISSN 0027-8424. PMID 12634428. doi:10.1073/pnas.0736565100.
    18. 1 2 Oneyama, Chitose; Nakano Hirofumi, Sharma Sreenath V (Mar. de 2002). «UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug». Oncogene (England) 21 (13): 2037-50. ISSN 0950-9232. PMID 11960376. doi:10.1038/sj.onc.1205271.
    19. 1 2 Navarro, P; Lozano E; Cano A (Aug. de 1993). «Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin». J. Cell. Sci. (ENGLAND). 105 ( Pt 4): 923-34. ISSN 0021-9533. PMID 8227214.
    20. 1 2 Takahashi, K; Suzuki K; Tsukatani Y (Jul. de 1997). «Induction of tyrosine phosphorylation and association of beta-catenin with EGF receptor upon tryptic digestion of quiescent cells at confluence». Oncogene (ENGLAND) 15 (1): 71-8. ISSN 0950-9232. PMID 9233779. doi:10.1038/sj.onc.1201160.
    21. ↑ Dobrosotskaya, I Y; James G L (Apr. de 2000). «MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures». Biochem. Biophys. Res. Commun. (UNITED STATES) 270 (3): 903-9. ISSN 0006-291X. PMID 10772923. doi:10.1006/bbrc.2000.2471.
    22. ↑ Geng, L; Burrow C R, Li H P, Wilson P D (Dec. de 2000). «Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation». Biochim. Biophys. Acta (NETHERLANDS) 1535 (1): 21-35. ISSN 0006-3002. PMID 11113628.
    23. 1 2 Shibamoto, S; Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson K R, Wheelock M J, Matsuyoshi N, Takeichi M (Mar. de 1995). «Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes». J. Cell Biol. (UNITED STATES) 128 (5): 949-57. ISSN 0021-9525. PMID 7876318.
    24. ↑ Rao, Radhakrishna K; Basuroy Shyamali, Rao Vijay U, Karnaky Jr Karl J, Gupta Akshay (Dec. de 2002). «Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress». Biochem. J. (England) 368 (Pt 2): 471-81. ISSN 0264-6021. PMID 12169098. doi:10.1042/BJ20011804.
    25. ↑ Huber, A H; Weis W I (mayo. de 2001). «The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin». Cell (United States) 105 (3): 391-402. ISSN 0092-8674. PMID 11348595.
    26. 1 2 Schmeiser, K; Grand R J (Apr. de 1999). «The fate of E- and P-cadherin during the early stages of apoptosis». Cell Death Differ. (ENGLAND) 6 (4): 377-86. ISSN 1350-9047. PMID 10381631. doi:10.1038/sj.cdd.4400504.
    27. ↑ Pai, Rama; Dunlap Debra, Qing Jing, Mohtashemi Iman, Hotzel Kathy, French Dorothy M (Jul. de 2008). «Inhibition of fibroblast growth factor 19 reduces tumor growth by modulating beta-catenin signaling». Cancer Res. (United States) 68 (13): 5086-95. PMID 18593907. doi:10.1158/0008-5472.CAN-07-2325.
    28. 1 2 Yoon, Young-Mee; Baek Kwan-Hyuck, Jeong Sook-Jung, Shin Hyun-Jin, Ha Geun-Hyoung, Jeon Ae-Hwa, Hwang Sang-Gu, Chun Jang-Soo, Lee Chang-Woo (Sep. de 2004). «WD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphase». FEBS Lett. (Netherlands) 575 (1-3): 23-9. ISSN 0014-5793. PMID 15388328. doi:10.1016/j.febslet.2004.07.089.
    29. ↑ Laoukili, Jamila; Alvarez-Fernandez Monica, Stahl Marie, Medema René H (Sep. de 2008). «FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner». Cell Cycle (United States) 7 (17): 2720-6. PMID 18758239.
    30. ↑ Daniel, J M; Reynolds A B (Sep. de 1995). «The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin». Mol. Cell. Biol. (UNITED STATES) 15 (9): 4819-24. ISSN 0270-7306. PMID 7651399.
    31. ↑ Ireton, Renee C; Davis Michael A, van Hengel Jolanda, Mariner Deborah J, Barnes Kirk, Thoreson Molly A, Anastasiadis Panos Z, Matrisian Linsey, Bundy Linda M, Sealy Linda, Gilbert Barbara, van Roy Frans, Reynolds Albert B (Nov. de 2002). «A novel role for p120 catenin in E-cadherin function». J. Cell Biol. (United States) 159 (3): 465-76. ISSN 0021-9525. PMID 12427869. doi:10.1083/jcb.200205115.
    32. ↑ Bonné, Stefan; Gilbert Barbara, Hatzfeld Mechthild, Chen Xinyu, Green Kathleen J, van Roy Frans (Apr. de 2003). «Defining desmosomal plakophilin-3 interactions». J. Cell Biol. (United States) 161 (2): 403-16. ISSN 0021-9525. PMID 12707304. doi:10.1083/jcb.200303036.
    33. ↑ Ohkubo, T; Ozawa M (Jul. de 1999). «p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity». J. Biol. Chem. (UNITED STATES) 274 (30): 21409-15. ISSN 0021-9258. PMID 10409703.
    34. ↑ Klingelhöfer, J; Troyanovsky R B, Laur O Y, Troyanovsky S (Aug. de 2000). «Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions». J. Cell. Sci. (ENGLAND). 113 ( Pt 16): 2829-36. ISSN 0021-9533. PMID 10910767.
    35. ↑ Li, Z; Kim S H, Higgins J M, Brenner M B, Sacks D B (Dec. de 1999). «IQGAP1 and calmodulin modulate E-cadherin function». J. Biol. Chem. (UNITED STATES) 274 (53): 37885-92. ISSN 0021-9258. PMID 10608854.
    36. ↑ Vodermaier, Hartmut C; Gieffers Christian, Maurer-Stroh Sebastian, Eisenhaber Frank, Peters Jan-Michael (Sep. de 2003). «TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1». Curr. Biol. (England) 13 (17): 1459-68. ISSN 0960-9822. PMID 12956947.
    37. ↑ Shibata, T; Gotoh M; Ochiai A; Hirohashi S (Aug. de 1994). «Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation». Biochem. Biophys. Res. Commun. (UNITED STATES) 203 (1): 519-22. ISSN 0006-291X. PMID 8074697. doi:10.1006/bbrc.1994.2213.
    38. ↑ Hinck, L; Näthke I S, Papkoff J, Nelson W J (Jun. de 1994). «Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly». J. Cell Biol. (UNITED STATES) 125 (6): 1327-40. ISSN 0021-9525. PMID 8207061.
    39. ↑ Knudsen, K A; Wheelock M J (Aug. de 1992). «Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin». J. Cell Biol. (UNITED STATES) 118 (3): 671-9. ISSN 0021-9525. PMID 1639850.
    40. ↑ Nourry, Claire; Maksumova Lola, Pang Mona, Liu Xiaohong, Wang Tongwen (mayo. de 2004). «Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1». BMC Cell Biol. (England) 5: 20. PMID 15144564. doi:10.1186/1471-2121-5-20.

    Enlaces externos