Caveolina-1

Caveolina-1
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	CAV1 (HGNC: 1527) CAV; MSTP085; VIP21
Identificadores; externos	OMIM: 601047 ; EBI: CAV1; GeneCards: Gen CAV1; UniProt: CAV1;
Locus	Cr. 7 q31
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
857
Q03135	n/a
NM_001753	n/a
	[editar datos en Wikidata]

La caveolina-1 (CAV1) es una proteína codificada en humanos por el gen CAV1.

La proteína estructural codificada por este gen es el principal componente de las caveolas formadas en la membrana plasmática de la mayoría de tipos celulares. La caveolina 1 une subunidades de integrinas a la tirosina quinasa FYN, como paso previo al inicio de la vía Ras-ERK para promover la progresión del ciclo celular. El gen CAV1 es un candidato a ser un gen supresor de tumores y un regulador negativo de la cascada Ras-p42/44 MAPK. Los genes CAV1 y CAV2 se encuentran próximos en el genoma, concretamente en el cromosoma 7, y expresan proteínas que co-localizan y forman complejos heterooligoméricos estables. Mediante el uso de codones de iniciación alternativos en el mismo marco de lectura, se codifican dos isoformas (alfa y beta) de la proteína a partir de un único transcrito del gen.

Interacciones

La caveolina-1 ha demostrado ser capaz de interaccionar con:

Véase también

Caveolina

Referencias

↑ Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (mayo de 1999). «Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors». Genomics 56 (3): 355-6. PMID 10087206. doi:10.1006/geno.1998.5723.
↑ «Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa».
↑ Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. de 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9): 6727-38. ISSN 0021-9258. PMID 11102446. doi:10.1074/jbc.M008340200.
↑ García-Cardeña, G; Fan R, Stern D F, Liu J, Sessa W C (Nov. de 1996). «Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1». J. Biol. Chem. (UNITED STATES) 271 (44): 27237-40. ISSN 0021-9258. PMID 8910295.
↑ Lu, M L; Schneider M C, Zheng Y, Zhang X, Richie J P (Apr. de 2001). «Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation». J. Biol. Chem. (United States) 276 (16): 13442-51. ISSN 0021-9258. PMID 11278309. doi:10.1074/jbc.M006598200.
↑ Ikezu, T; Trapp B D, Song K S, Schlegel A, Lisanti M P, Okamoto T (Apr. de 1998). «Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein». J. Biol. Chem. (UNITED STATES) 273 (17): 10485-95. ISSN 0021-9258. PMID 9553108.
↑ Schubert, Anne-Lane; Schubert William, Spray David C, Lisanti Michael P (mayo. de 2002). «Connexin family members target to lipid raft domains and interact with caveolin-1». Biochemistry (United States) 41 (18): 5754-64. ISSN 0006-2960. PMID 11980479.
↑ Felley-Bosco, E; Bender F C, Courjault-Gautier F, Bron C, Quest A F (Dec. de 2000). «Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14334-9. ISSN 0027-8424. PMID 11114180. doi:10.1073/pnas.250406797.
↑ Couet, J; Sargiacomo M, Lisanti M P (Nov. de 1997). «Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities». J. Biol. Chem. (UNITED STATES) 272 (48): 30429-38. ISSN 0021-9258. PMID 9374534.
↑ Yamaguchi, Tomohiro; Murata Yasunobu, Fujiyoshi Yoshinori, Doi Tomoko (Apr. de 2003). «Regulated interaction of endothelin B receptor with caveolin-1». Eur. J. Biochem. (Germany) 270 (8): 1816-27. ISSN 0014-2956. PMID 12694195.
1 2 Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (Mar. de 1999). «Caveolin is an inhibitor of platelet-derived growth factor receptor signaling». Exp. Cell Res. (UNITED STATES) 247 (2): 380-8. ISSN 0014-4827. PMID 10066366. doi:10.1006/excr.1998.4379.
↑ Liou, J Y; Deng W G, Gilroy D W, Shyue S K, Wu K K (Sep. de 2001). «Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts». J. Biol. Chem. (United States) 276 (37): 34975-82. ISSN 0021-9258. PMID 11432874. doi:10.1074/jbc.M105946200.
↑ Feng, X; Gaeta M L, Madge L A, Yang J H, Bradley J R, Pober J S (Mar. de 2001). «Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors». J. Biol. Chem. (United States) 276 (11): 8341-9. ISSN 0021-9258. PMID 11112773. doi:10.1074/jbc.M007116200.
↑ Cao, Haiming; Courchesne William E, Mastick Cynthia Corley (Mar. de 2002). «A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase». J. Biol. Chem. (United States) 277 (11): 8771-4. ISSN 0021-9258. PMID 11805080. doi:10.1074/jbc.C100661200.
↑ Schlegel, A; Wang C, Pestell R G, Lisanti M P (Oct. de 2001). «Ligand-independent activation of oestrogen receptor alpha by caveolin-1». Biochem. J. (England) 359 (Pt 1): 203-10. ISSN 0264-6021. PMID 11563984.
↑ Breuza, Lionel; Corby Séverine, Arsanto Jean-Pierre, Delgrossi Marie-Hélène, Scheiffele Peter, Le Bivic André (Dec. de 2002). «The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells». J. Cell. Sci. (England) 115 (Pt 23): 4457-67. ISSN 0021-9533. PMID 12414992.
↑ Scherer, P E; Lewis R Y, Volonte D, Engelman J A, Galbiati F, Couet J, Kohtz D S, van Donselaar E, Peters P, Lisanti M P (Nov. de 1997). «Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo». J. Biol. Chem. (UNITED STATES) 272 (46): 29337-46. ISSN 0021-9258. PMID 9361015.
↑ Zheng, Xiangjian; Bollinger Bollag Wendy (Dec. de 2003). «Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation». J. Invest. Dermatol. (United States) 121 (6): 1487-95. ISSN 0022-202X. PMID 14675200. doi:10.1111/j.1523-1747.2003.12614.x.
↑ Czarny, M; Fiucci G; Lavie Y; Banno Y; Nozawa Y; Liscovitch M (Feb. de 2000). «Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains». FEBS Lett. (NETHERLANDS) 467 (2-3): 326-32. ISSN 0014-5793. PMID 10675563.
↑ Vargas, Leonardo; Nore Beston F, Berglof Anna, Heinonen Juhana E, Mattsson Pekka T, Smith C I Edvard, Mohamed Abdalla J (Mar. de 2002). «Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx». J. Biol. Chem. (United States) 277 (11): 9351-7. ISSN 0021-9258. PMID 11751885. doi:10.1074/jbc.M108537200.
↑ Zhou, Minglong; Parr Rebecca D, Petrescu Anca D, Payne H Ross, Atshaves Barbara P, Kier Ann B, Ball Judith M, Schroeder Friedhelm (Jun. de 2004). «Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo». Biochemistry (United States) 43 (23): 7288-306. ISSN 0006-2960. PMID 15182174. doi:10.1021/bi035914n.

Base de datos	Referencia
ENSEMBL	SG00000105974
UniProt	Q03135

Datos: Q17855958

[pmid10087206-1] Fra AM, Mastroianni N, Mancini M, Pasqualetto E, Sitia R (mayo de 1999). «Human caveolin-1 and caveolin-2 are closely linked genes colocalized with WI-5336 in a region of 7q31 frequently deleted in tumors». Genomics 56 (3): 355-6. PMID 10087206. doi:10.1006/geno.1998.5723.

[2] «Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa».

[pmid11102446-3] Razani, B; Zhang X L, Bitzer M, von Gersdorff G, Böttinger E P, Lisanti M P (Mar. de 2001). «Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor». J. Biol. Chem. (United States) 276 (9): 6727-38. ISSN 0021-9258. PMID 11102446. doi:10.1074/jbc.M008340200.

[pmid8910295-4] García-Cardeña, G; Fan R, Stern D F, Liu J, Sessa W C (Nov. de 1996). «Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1». J. Biol. Chem. (UNITED STATES) 271 (44): 27237-40. ISSN 0021-9258. PMID 8910295.

[pmid11278309-5] Lu, M L; Schneider M C, Zheng Y, Zhang X, Richie J P (Apr. de 2001). «Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation». J. Biol. Chem. (United States) 276 (16): 13442-51. ISSN 0021-9258. PMID 11278309. doi:10.1074/jbc.M006598200.

[pmid9553108-6] Ikezu, T; Trapp B D, Song K S, Schlegel A, Lisanti M P, Okamoto T (Apr. de 1998). «Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein». J. Biol. Chem. (UNITED STATES) 273 (17): 10485-95. ISSN 0021-9258. PMID 9553108.

[pmid11980479-7] Schubert, Anne-Lane; Schubert William, Spray David C, Lisanti Michael P (mayo. de 2002). «Connexin family members target to lipid raft domains and interact with caveolin-1». Biochemistry (United States) 41 (18): 5754-64. ISSN 0006-2960. PMID 11980479.

[pmid11114180-8] Felley-Bosco, E; Bender F C, Courjault-Gautier F, Bron C, Quest A F (Dec. de 2000). «Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (26): 14334-9. ISSN 0027-8424. PMID 11114180. doi:10.1073/pnas.250406797.

[pmid9374534-9] Couet, J; Sargiacomo M, Lisanti M P (Nov. de 1997). «Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities». J. Biol. Chem. (UNITED STATES) 272 (48): 30429-38. ISSN 0021-9258. PMID 9374534.

[pmid12694195-10] Yamaguchi, Tomohiro; Murata Yasunobu, Fujiyoshi Yoshinori, Doi Tomoko (Apr. de 2003). «Regulated interaction of endothelin B receptor with caveolin-1». Eur. J. Biochem. (Germany) 270 (8): 1816-27. ISSN 0014-2956. PMID 12694195.

[pmid10066366-11] 1 2 Yamamoto, M; Toya Y, Jensen R A, Ishikawa Y (Mar. de 1999). «Caveolin is an inhibitor of platelet-derived growth factor receptor signaling». Exp. Cell Res. (UNITED STATES) 247 (2): 380-8. ISSN 0014-4827. PMID 10066366. doi:10.1006/excr.1998.4379.

[pmid11432874-12] Liou, J Y; Deng W G, Gilroy D W, Shyue S K, Wu K K (Sep. de 2001). «Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts». J. Biol. Chem. (United States) 276 (37): 34975-82. ISSN 0021-9258. PMID 11432874. doi:10.1074/jbc.M105946200.

[pmid11112773-13] Feng, X; Gaeta M L, Madge L A, Yang J H, Bradley J R, Pober J S (Mar. de 2001). «Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors». J. Biol. Chem. (United States) 276 (11): 8341-9. ISSN 0021-9258. PMID 11112773. doi:10.1074/jbc.M007116200.

[pmid11805080-14] Cao, Haiming; Courchesne William E, Mastick Cynthia Corley (Mar. de 2002). «A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase». J. Biol. Chem. (United States) 277 (11): 8771-4. ISSN 0021-9258. PMID 11805080. doi:10.1074/jbc.C100661200.

[pmid11563984-15] Schlegel, A; Wang C, Pestell R G, Lisanti M P (Oct. de 2001). «Ligand-independent activation of oestrogen receptor alpha by caveolin-1». Biochem. J. (England) 359 (Pt 1): 203-10. ISSN 0264-6021. PMID 11563984.

[pmid12414992-16] Breuza, Lionel; Corby Séverine, Arsanto Jean-Pierre, Delgrossi Marie-Hélène, Scheiffele Peter, Le Bivic André (Dec. de 2002). «The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco-2 cells». J. Cell. Sci. (England) 115 (Pt 23): 4457-67. ISSN 0021-9533. PMID 12414992.

[pmid9361015-17] Scherer, P E; Lewis R Y, Volonte D, Engelman J A, Galbiati F, Couet J, Kohtz D S, van Donselaar E, Peters P, Lisanti M P (Nov. de 1997). «Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo». J. Biol. Chem. (UNITED STATES) 272 (46): 29337-46. ISSN 0021-9258. PMID 9361015.

[pmid14675200-18] Zheng, Xiangjian; Bollinger Bollag Wendy (Dec. de 2003). «Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation». J. Invest. Dermatol. (United States) 121 (6): 1487-95. ISSN 0022-202X. PMID 14675200. doi:10.1111/j.1523-1747.2003.12614.x.

[pmid10675563-19] Czarny, M; Fiucci G; Lavie Y; Banno Y; Nozawa Y; Liscovitch M (Feb. de 2000). «Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains». FEBS Lett. (NETHERLANDS) 467 (2-3): 326-32. ISSN 0014-5793. PMID 10675563.

[pmid11751885-20] Vargas, Leonardo; Nore Beston F, Berglof Anna, Heinonen Juhana E, Mattsson Pekka T, Smith C I Edvard, Mohamed Abdalla J (Mar. de 2002). «Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx». J. Biol. Chem. (United States) 277 (11): 9351-7. ISSN 0021-9258. PMID 11751885. doi:10.1074/jbc.M108537200.

[pmid15182174-21] Zhou, Minglong; Parr Rebecca D, Petrescu Anca D, Payne H Ross, Atshaves Barbara P, Kier Ann B, Ball Judith M, Schroeder Friedhelm (Jun. de 2004). «Sterol carrier protein-2 directly interacts with caveolin-1 in vitro and in vivo». Biochemistry (United States) 43 (23): 7288-306. ISSN 0006-2960. PMID 15182174. doi:10.1021/bi035914n.