GPS2

Supresor 2 de la ruta de proteínas G
Identificadores
Símbolos	GPS2 (HGNC: 4550) AMF-1; MGC104294; MGC119287; MGC119288; MGC119289
Identificadores; externos	OMIM: 601935 ; EBI: GPS2; GeneCards: Gen GPS2; UniProt: GPS2;
Ortólogos
Humano	Ratón
2874
NP_004480	n/a
	[editar datos en Wikidata]

El supresor 2 de la ruta de proteínas G (GPS2) es una proteína codificada en humanos por el gen GPS2.

Este gen codifica una proteína implicada en la cascada de señalización de las MAP quinasas y las proteínas G. Cuando este gen es sobre-expresado en células de mamífero, es capaz de suprimir la señal mediada por las MAPK y por la proteína Ras, e interfiere con la actividad de JNK, lo que sugiere que la función de este gen consiste en la represión de la señal. La proteína GPS2 es una subunidad integral del complejo NCOR1-HDAC3, y se ha demostrado que este complejo inhibe la activación de JNK por medio de esta subunidad, por lo que podría proveer potencialmente un mecanismo alternativo para el antagonismo mediado por hormonas de AP-1.

Interacciones

La proteína GPS2 ha demostrado ser capaz de interaccionar con:

Referencias

↑ Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J (Jan de 1997). «Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells». Mol Cell Biol 16 (12): 6698-706. PMC 231672. PMID 8943324.
1 2 «Entrez Gene: GPS2 G protein pathway suppressor 2».
↑ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (Aug. de 2004). «Identification of interaction partners and substrates of the cyclin A1-CDK2 complex». J. Biol. Chem. (United States) 279 (32): 33727-41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.
1 2 3 Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. de 2002). «The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell (United States) 9 (3): 611-23. ISSN 1097-2765. PMID 11931768.
↑ Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. de 2003). «N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso». Mol. Cell (United States) 12 (3): 723-34. ISSN 1097-2765. PMID 14527417.
↑ Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. de 2003). «Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1». EMBO J. (England) 22 (6): 1336-46. ISSN 0261-4189. PMID 12628926. doi:10.1093/emboj/cdg120.
↑ Peng, Y C; Kuo F, Breiding D E, Wang Y F, Mansur C P, Androphy E J (Sep. de 2001). «AMF1 (GPS2) modulates p53 transactivation». Mol. Cell. Biol. (United States) 21 (17): 5913-24. ISSN 0270-7306. PMID 11486030.
↑ Peng, Y C; Breiding D E, Sverdrup F, Richard J, Androphy E J (Jul. de 2000). «AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins». J. Virol. (UNITED STATES) 74 (13): 5872-9. ISSN 0022-538X. PMID 10846067.
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

Datos: Q18026450

[pmid8943324-1] Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, Chang CY, Xie W, Colicelli J (Jan de 1997). «Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells». Mol Cell Biol 16 (12): 6698-706. PMC 231672. PMID 8943324.

[entrez-2] 1 2 «Entrez Gene: GPS2 G protein pathway suppressor 2».

[pmid15159402-3] Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten (Aug. de 2004). «Identification of interaction partners and substrates of the cyclin A1-CDK2 complex». J. Biol. Chem. (United States) 279 (32): 33727-41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200.

[pmid11931768-4] 1 2 3 Zhang, Jinsong; Kalkum Markus, Chait Brian T, Roeder Robert G (Mar. de 2002). «The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2». Mol. Cell (United States) 9 (3): 611-23. ISSN 1097-2765. PMID 11931768.

[pmid14527417-5] Yoon, Ho-Geun; Chan Doug W, Reynolds Albert B, Qin Jun, Wong Jiemin (Sep. de 2003). «N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso». Mol. Cell (United States) 12 (3): 723-34. ISSN 1097-2765. PMID 14527417.

[pmid12628926-6] Yoon, Ho-Geun; Chan Doug W, Huang Zhi-Qing, Li Jiwen, Fondell Joseph D, Qin Jun, Wong Jiemin (Mar. de 2003). «Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1». EMBO J. (England) 22 (6): 1336-46. ISSN 0261-4189. PMID 12628926. doi:10.1093/emboj/cdg120.

[pmid11486030-7] Peng, Y C; Kuo F, Breiding D E, Wang Y F, Mansur C P, Androphy E J (Sep. de 2001). «AMF1 (GPS2) modulates p53 transactivation». Mol. Cell. Biol. (United States) 21 (17): 5913-24. ISSN 0270-7306. PMID 11486030.

[pmid10846067-8] Peng, Y C; Breiding D E, Sverdrup F, Richard J, Androphy E J (Jul. de 2000). «AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins». J. Virol. (UNITED STATES) 74 (13): 5872-9. ISSN 0022-538X. PMID 10846067.

[pmid16189514-9] Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.