Maria Manuel Mota
Algunas publicaciones
- a.c. Pena, n. Penacho, l. Mancio-Silva, r. Neres, j.d. Seixas, a.c. Fernandes, c.c. Romão, m.m. Mota, g.j. Bernardes, a. Pamplona. 2012. A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria. Antimicrob Agents Chemother. 56 (3): 1281-90
- f.p. da Cruz, c. Martin, k. Buchholz, m.j. Lafuente-Monasterio, t. Rodrigues, b. Sönnichsen, r. Moreira, f.j. Gamo, m. Marti, m.m. Mota, m. Hannus, m. Prudêncio. 2012. Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug. J Infect Dis. 205(8): 1278-86
- r. Capela, g.g. Cabal, p.j. Rosenthal, j. Gut, m.m. Mota, r. Moreira, f. Lopes, m. Prudêncio. 2011. Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Anti-Malarial Strategy. Antimicrob Agents Chemother
- c.s. Gomes-Santos, j. Braks, m. Prudêncio, c. Carret, a.r. Gomes, a. Pain, t. Feltwell, s. Khan, a. Waters, c. Janse, g.r. Mair, m.m. Mota. 2011. Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio. PLoS Pathog 7(5):e1002046
- s. Portugal, c. Carret, m. Recker, a. Armitage, d. Sullivan, roy Cindy, c.j. Newbold, h. Drakesmith, m.m. Mota. 2011. Host-mediated control of Malaria Superinfection. Nature Medicine 17 (6): 732-7
- r. Frita, m. Rebelo, a. Pamplona, a.m. Vigario, m.m. Mota, m.p. Grobusch, t. Hänscheid. 2011. Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing. Malar J. 10:74
- b. Douradinha, k.d. Augustijn, s.g. Moore, j. Ramesar, m.m. Mota, a.p. Waters, c.j. Janse, j. Thompson. 2011. Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are essential for malaria parasite transmission from the mosquito to the host. Malar J. 10(1):71
- k. Slavic, m.j. Delves, m. Prudêncio, a.m. Talman, u. Straschil, e.t. Derbyshire, z. Xu, r.e. Sinden, m.m. Mota, c. Morin, r. Tewari, s. Krishna, h.m. Staines. 2011. Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrob Agents Chemother 55(6): 2824-30
- j. Langhorne, p. Buffet, m. Galinski, m. Good, j. Harty, d. Leroy, m.m. Mota, e. Pasini, l. Renia, e. Riley, m. Stins, p. Duffy. 2011. The relevance of non-human primate and rodent malaria models for humans. Malar J. 10(1): 23
- j. Lavrado, g.g. Cabal, m. Prudêncio, m.m. Mota, j. Gut, p.j. Rosenthal, c. Díaz, r.c. Guedes, d.j. Dos Santos, e. Bichenkova, k.t. Douglas, r. Moreira, a. Paulo. 2011. Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure-Antimalarial Activity Relationships and Mechanistic Studies. J Med Chem. 54(3): 734
- f.g. Baptista, a. Pamplona, a.c. Pena, m.m. Mota, s. Pied, a.m. Vigário. 2010. Accumulation of Plasmodium-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice. Infect Immun. 78(9): 4033-9
- d.p. Dowling, m. Ilies, k.l. Olszewski, s. Portugal, m.m. Mota, m. Llinás, d.w. Christianson. 2010. Crystal Structure of Arginase from Plasmodium falciparum and Implications for l-Arginine Depletion in Malarial Infection. Biochemistry 49(26): 5600-8
- s. Epiphanio, m.g. Campos, a. Pamplona, d. Carapau, a.c. Pena, r. Ataíde, c.a. Monteiro, n. Félix, a. Costa-Silva, c.r. Marinho, s. Dias, m.m. Mota. 2010. VEGF promotes malaria-associated acute lung injury in mice. PLoS Pathog 6(5): e1000916
- p. Liehl, a.r. França, m. Prudêncio, e. Latz, a. Zaidman-Rémy, m.m. Mota. 2010. Phosphothioate oligodeoxynucleotides inhibit Plasmodium sporozoite gliding motility. Cell Microbiol. 2(4): 506
- i.h. Ploemen, m. Prudêncio, b.g. Douradinha, j. Ramesar, j. Fonager, g.j. van Gemert, a.j. Luty, c.c. Hermsen, r.w. Sauerwein, f.g. Baptista, m.m. Mota, a.p. Waters, i. Que, c.w. Lowik, s.m. Khan, c.j. Janse, b.m. Franke-Fayard. 2009. Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging. PLoS One 4(11): e7881
- o. Silvie, m.m. Mota, k. Matuschewski, m. Prudêncio. 2008. Interactions of the malaria parasite and its mammalian host. Curr Opin Microbiol. 11 (4): 352-9
- m.m. Mota, a. Rodriguez. 2008. New pieces for the malaria liver stage puzzle: where will they fit? Cell Host Microbe 14;3 (2): 63-5
- ------------. 2006. Be in motion. Mol Microbiol. 60 (6): 1327-8
- ------------, s. Giordano, a. Rodriguez. 2004. Targeting Plasmodium host cells: survival within hepatocytes. Trends Mol Med. 10: 487-92
- ------------, a. Rodriguez. 2004. Migration through host cells: the first steps of Plasmodium sporozoites in the mammalian host. Cell Microbiol 6: 1113-8
Patentes
- Método para la prevención de la infección de la malaria en humanos por antagonistas del factor de crecimiento de hepatocitos. Sudáfrica: patente No. 2005/ 08178. Sobre la base de la International PCT Publication N.º. WO2004/080420, African Reg. Ind. Prop. Org. – Application N.º. AP/P/2005/003411, Brasil – Aplicación N.º. PI040826 8-0, China – publicación N.º. CN1809382A, Europa – publicación N.º. 601378, Hong Kong – publicación N.º. 1093903A, Japón – aplicación N.º. 2006-507105, EE. UU.- publicación N.º. US 2004-0185050 A1
- Uso de inhibidores de proteínas scavenger receptoras para el tratamiento de enfermedades infecciosas (WO/2007/101710), aplicación internacional N.º. PCT/EP2007/002110, fases nacionales inicializadas en EE. UU., UE, Canadá, China en octubre de 2008
- Uso de inhibidores de quinasas de receptores para el tratamiento de enfermedades infecciosas, aplicación provisional de EE. UU. N.º. 61/110,217, archivado 31 de octubre de 2008