NEK2

Serina/treonina quinasa Nek2

Estructura tridimensional de la proteína NEK2.
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Lista de códigos PDB
2jav
Identificadores
Símbolos NEK2 (HGNC: 7745) HsPK 21, HsPK21, NEK2A, NLK1
Identificadores
externos
  • GeneCards: Gen NEK2
  • UniProt: NEK2
    • Locus Cr. 1 q32.3
    Ortólogos
    Especies
    Humano Ratón
    Entrez
    4751
    UniProt
    P51955 n/a
    RefSeq
    (ARNm)
    NP_002488 n/a
    [editar datos en Wikidata]

    La serina/treonina quinasa Nek2 es una enzima codificada en humanos por el gen nek2.

    Interacciones

    La proteína NEK2 ha demostrado ser capaz de interaccionar con:

    Referencias

    1. ↑ Schultz SJ, Nigg EA (Feb de 1994). «Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans». Cell Growth Differ 4 (10): 821-30. PMID 8274451.
    2. ↑ «Entrez Gene: NEK2 NIMA (never in mitosis gene a)-related kinase 2».
    3. ↑ Lou, Yang; Xie Wei, Zhang Dong-Fang, Yao Jian-hui, Luo Zhao-feng, Wang Yu-Zhen, Shi Yun-Yu, Yao Xue-Biao (Aug. de 2004). «Nek2A specifies the centrosomal localization of Erk2». Biochem. Biophys. Res. Commun. (United States) 321 (2): 495-501. ISSN 0006-291X. PMID 15358203. doi:10.1016/j.bbrc.2004.06.171.
    4. ↑ Chen, Yumay; Riley Daniel J, Zheng Lei, Chen Phang-Lang, Lee Wen-Hwa (Dec. de 2002). «Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation». J. Biol. Chem. (United States) 277 (51): 49408-16. ISSN 0021-9258. PMID 12386167. doi:10.1074/jbc.M207069200.
    5. ↑ Chen, Y; Sharp Z D, Lee W H (Sep. de 1997). «HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins». J. Biol. Chem. (UNITED STATES) 272 (38): 24081-7. ISSN 0021-9258. PMID 9295362.

    Enlaces externos