NLGN1

NLGN1
Estructuras disponibles
PDB	Búsqueda ortóloga: PDBe RCSB
Lista de codigos id de PDB
	3B3Q
Identificadores
Alias	NLGN1, NL1, neuroligin 1
IDs externos	OMIM: 600568 MGI: 2179435 HomoloGene: 56690 GeneCards: NLGN1
Enfermedades genéticamente relacionadas
	periodontitis
Ontología génica
Función molecular	• PDZ domain binding; • protein dimerization activity; • cell adhesion molecule binding; • scaffold protein binding; • GO:0004091 carboxylic ester hydrolase activity; • neurexin family protein binding; • amyloid-beta binding; • signaling receptor activity;
Componente celular	• sinapsis; • componente integral de membrana; • NMDA selective glutamate receptor complex; • aparato de Golgi; • unión celular; • dendritic shaft; • filopodium tip; • Espina dendrítica; • postsynaptic membrane; • membrana; • dendrita; • excitatory synapse; • external side of plasma membrane; • cell surface; • presynapse; • GO:0097483, GO:0097481 postsynaptic density; • membrana plasmática; • integral component of postsynaptic membrane; • integral component of plasma membrane; • spanning component of membrane; • postsynapse; • glutamatergic synapse; • asymmetric, glutamatergic, excitatory synapse; • integral component of postsynaptic specialization membrane;
Proceso biológico	• NMDA glutamate receptor clustering; • positive regulation of ruffle assembly; • positive regulation of synaptic vesicle exocytosis; • regulation of AMPA receptor activity; • proceso rítmico; • positive regulation of synaptic transmission, glutamatergic; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • positive regulation of circadian sleep/wake cycle, wakefulness; • regulation of respiratory gaseous exchange by nervous system process; • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; • protein heterotetramerization; • synaptic vesicle transport; • terminal button organization; • synapse organization; • positive regulation of synaptic transmission, GABAergic; • postsynaptic density protein 95 clustering; • receptor localization to synapse; • protein localization to synapse; • neurexin clustering involved in presynaptic membrane assembly; • positive regulation of synaptic vesicle endocytosis; • synaptic vesicle targeting; • protein homooligomerization; • positive regulation of protein localization to synapse; • neuron projection development; • Hipótesis de la señal; • GO:0010740 positive regulation of intracellular signal transduction; • Potenciación a largo plazo; • desarrollo neural; • AMPA glutamate receptor clustering; • neuronal signal transduction; • synaptic vesicle clustering; • positive regulation of synaptic vesicle clustering; • cytoskeletal matrix organization at active zone; • Sinaptogénesis; • establishment of protein localization; • modulation of chemical synaptic transmission; • positive regulation of filopodium assembly; • adherencia celular; • regulation of neuron differentiation; • neuron cell-cell adhesion; • positive regulation of dendritic spine development; • regulation of NMDA receptor activity; • positive regulation of excitatory postsynaptic potential; • negative regulation of dendritic spine morphogenesis; • positive regulation of synapse assembly; • excitatory synapse assembly; • positive regulation of presynaptic active zone assembly; • retrograde trans-synaptic signaling by trans-synaptic protein complex; • synaptic vesicle endocytosis; • postsynaptic membrane assembly; • presynaptic membrane assembly; • cellular response to calcium ion; • postsynaptic specialization assembly; • presynapse assembly; • regulation of presynapse organization; • synaptic membrane adhesion; • neuron projection arborization;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	Más referencias a datos de expressión
Ortólogos
	22871
	192167
	ENSG00000169760
	ENSMUSG00000063887
	Q8N2Q7
	Q99K10
NM_014932; NM_001365923; NM_001365924; NM_001365925; NM_001365926;
	NM_001365927; NM_001365928; NM_001365929; NM_001365930; NM_001365931; NM_001365932; NM_001365933; NM_001365934; NM_001365935; NM_001365936
	NM_001163387; NM_138666; NM_001357095; NM_001357096; NM_001357097
NP_055747; NP_001352852; NP_001352853; NP_001352854; NP_001352855;
	NP_001352856; NP_001352857; NP_001352858; NP_001352859; NP_001352860; NP_001352861; NP_001352862; NP_001352863; NP_001352864; NP_001352865
	NP_001156859; NP_619607; NP_001344024; NP_001344025; NP_001344026
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La neuroligina-1 es una proteína que en humanos está codificada por el gen NLGN1 .

Este gen codifica un miembro de la familia de neuroliginas de proteínas de la superficie celular neuronal. La neuroligina-1 actúa como ligando específico del sitio de empalme para las β-neurexinas y se ha demostrado que se localiza en el compartimiento postsináptico en las sinapsis excitadoras y participa en la formación y remodelación de las sinapsis del sistema nervioso central.

Interacciones

Se ha demostrado que NLGN1 interactúa con NRXN1 y DLG4 .

Referencias

↑ «Diseases that are genetically associated with NLGN1 view/edit references on wikidata».
↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ «The structure and expression of the human neuroligin-3 gene». Gene 246 (1–2): 303-10. April 2000. PMID 10767552. doi:10.1016/S0378-1119(00)00049-4.
↑ «Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Research 7 (2): 143-50. April 2000. PMID 10819331. doi:10.1093/dnares/7.2.143.
1 2 «Entrez Gene: NLGN1 neuroligin 1».
1 2 «Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta». The Journal of Biological Chemistry 278 (50): 50497-505. December 2003. PMID 14522992. doi:10.1074/jbc.M306803200.
↑ «Structures, alternative splicing, and neurexin binding of multiple neuroligins». The Journal of Biological Chemistry 271 (5): 2676-82. February 1996. PMID 8576240. doi:10.1074/jbc.271.5.2676.
↑ «Binding of neuroligins to PSD-95». Science 277 (5331): 1511-5. September 1997. PMID 9278515. doi:10.1126/science.277.5331.1511.

Enlaces externos

En HomoloGene: NLGN1

En Genome:NLGN1
En MalaCards.Enfermedades que coinciden con:NLGN1
En Estudio de asociación del genoma completo (GWAS) NLGN1

Datos: Q18036551

[1] «Diseases that are genetically associated with NLGN1 view/edit references on wikidata».

[2] «Human PubMed Reference:».

[3] «Mouse PubMed Reference:».

[pmid10767552-4] «The structure and expression of the human neuroligin-3 gene». Gene 246 (1–2): 303-10. April 2000. PMID 10767552. doi:10.1016/S0378-1119(00)00049-4.

[pmid10819331-5] «Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro». DNA Research 7 (2): 143-50. April 2000. PMID 10819331. doi:10.1093/dnares/7.2.143.

[entrez-6] 1 2 «Entrez Gene: NLGN1 neuroligin 1».

[pmid14522992-7] 1 2 «Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta». The Journal of Biological Chemistry 278 (50): 50497-505. December 2003. PMID 14522992. doi:10.1074/jbc.M306803200.

[pmid8576240-8] «Structures, alternative splicing, and neurexin binding of multiple neuroligins». The Journal of Biological Chemistry 271 (5): 2676-82. February 1996. PMID 8576240. doi:10.1074/jbc.271.5.2676.

[pmid9278515-9] «Binding of neuroligins to PSD-95». Science 277 (5331): 1511-5. September 1997. PMID 9278515. doi:10.1126/science.277.5331.1511.