RANBP9

RANBP9
Identificadores
Alias	RANBP9, Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9
IDs externos	OMIM: 603854 MGI: 1928741 HomoloGene: 38057 GeneCards: RANBP9
Ontología génica
Función molecular	• enzyme binding; • GO:0001948, GO:0016582 unión a proteína plasmática;
Componente celular	• citoplasma; • citosol; • membrana plasmática; • membrana; • núcleo celular; • microtubule associated complex; • ubiquitin ligase complex;
Proceso biológico	• negative regulation of ERK1 and ERK2 cascade; • microtubule nucleation; • Guía de axón; • MAPK cascade; • GO:0034622 protein-containing complex assembly;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	; ; ; ;
	Más referencias a datos de expressión
Ortólogos
	10048
	56705
	ENSG00000010017
	ENSMUSG00000038546
	Q96S59
	P69566
	NM_005493
	NM_019930
	NP_005484
	NP_064314; NP_001391577
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

La proteína de unión a RAN 9 (RANBP9) es una proteína codificada en humanos por el gen ranbp9.

Este gen codifica una proteína que se une a RAN, una proteína que une GTP perteneciente a la superfamilia Ras esencial en la translocación de ARN y ciertas proteínas a través del poro nuclear hacia el núcleo celular. RANBP9 también ha demostrado interaccionar con otras proteínas como los proto-oncogenes c-Met, HIPK2, el receptor androgénico y Cdk11.

Interacciones

La proteína RANBP9 ha demostrado ser capaz de interaccionar con:

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec de 1998). «When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin». J Cell Biol 143 (4): 1041-52. PMC 2132962. PMID 9817760.
↑ Murrin LC, Talbot JN (Sep de 2007). «RanBPM, a scaffolding protein in the immune and nervous systems». J Neuroimmune Pharmacol 2 (3): 290-295. PMID 18040864.
1 2 «Entrez Gene: RANBP9 RAN binding protein 9».
↑ Wang, Dakun; Li Zaibo, Messing Edward M, Wu Guan (Sep. de 2002). «Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM». J. Biol. Chem. (United States) 277 (39): 36216-22. ISSN 0021-9258. PMID 12147692. doi:10.1074/jbc.M205111200.
↑ Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. de 2003). «Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M». J. Biol. Chem. (United States) 278 (49): 49573-81. ISSN 0021-9258. PMID 14500717. doi:10.1074/jbc.M307556200.
↑ Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct. de 2002). «Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM». Biochem. J. (England) 367 (Pt 1): 87-95. ISSN 0264-6021. PMID 12084015. doi:10.1042/BJ20011851.
↑ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. de 2003). «DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation». Hum. Mol. Genet. (England) 12 (13): 1591-608. ISSN 0964-6906. PMID 12812986.
1 2 Rao, Mira A; Cheng Helen, Quayle Alandra N, Nishitani Hideo, Nelson Colleen C, Rennie Paul S (Dec. de 2002). «RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor». J. Biol. Chem. (United States) 277 (50): 48020-7. ISSN 0021-9258. PMID 12361945. doi:10.1074/jbc.M209741200.
↑ Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. de 2002). «RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer». BMC Cancer (England) 2: 28. PMID 12421467.
↑ Wang, Ying; Marion Schneider E, Li Xin, Duttenhöfer Irina, Debatin Klaus, Hug Hubert (Sep. de 2002). «HIPK2 associates with RanBPM». Biochem. Biophys. Res. Commun. (United States) 297 (1): 148-53. ISSN 0006-291X. PMID 12220523.
↑ Umeda, M; Nishitani H; Nishimoto T (Jan. de 2003). «A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM». Gene (Netherlands) 303: 47-54. ISSN 0378-1119. PMID 12559565.

Enlaces externos

En HomoloGene: RANBP9

En Genome:RANBP9
En MalaCards.Enfermedades que coinciden con:RANBP9

Datos: Q18258603

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid9817760-3] Nakamura M, Masuda H, Horii J, Kuma K, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec de 1998). «When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin». J Cell Biol 143 (4): 1041-52. PMC 2132962. PMID 9817760.

[pmid18040864-4] Murrin LC, Talbot JN (Sep de 2007). «RanBPM, a scaffolding protein in the immune and nervous systems». J Neuroimmune Pharmacol 2 (3): 290-295. PMID 18040864.

[entrez-5] 1 2 «Entrez Gene: RANBP9 RAN binding protein 9».

[pmid12147692-6] Wang, Dakun; Li Zaibo, Messing Edward M, Wu Guan (Sep. de 2002). «Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM». J. Biol. Chem. (United States) 277 (39): 36216-22. ISSN 0021-9258. PMID 12147692. doi:10.1074/jbc.M205111200.

[pmid14500717-7] Zou, Yonglong; Lim Seunghwan, Lee Kangmoon, Deng Xiaobing, Friedman Eileen (Dec. de 2003). «Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M». J. Biol. Chem. (United States) 278 (49): 49573-81. ISSN 0021-9258. PMID 14500717. doi:10.1074/jbc.M307556200.

[pmid12084015-8] Ideguchi, Haruko; Ueda Atsuhisa, Tanaka Masatsugu, Yang Jun, Tsuji Takashi, Ohno Shigeru, Hagiwara Eri, Aoki Akiko, Ishigatsubo Yoshiaki (Oct. de 2002). «Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM». Biochem. J. (England) 367 (Pt 1): 87-95. ISSN 0264-6021. PMID 12084015. doi:10.1042/BJ20011851.

[pmid12812986-9] Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. de 2003). «DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation». Hum. Mol. Genet. (England) 12 (13): 1591-608. ISSN 0964-6906. PMID 12812986.

[pmid12361945-10] 1 2 Rao, Mira A; Cheng Helen, Quayle Alandra N, Nishitani Hideo, Nelson Colleen C, Rennie Paul S (Dec. de 2002). «RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor». J. Biol. Chem. (United States) 277 (50): 48020-7. ISSN 0021-9258. PMID 12361945. doi:10.1074/jbc.M209741200.

[pmid12421467-11] Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. de 2002). «RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer». BMC Cancer (England) 2: 28. PMID 12421467.

[pmid12220523-12] Wang, Ying; Marion Schneider E, Li Xin, Duttenhöfer Irina, Debatin Klaus, Hug Hubert (Sep. de 2002). «HIPK2 associates with RanBPM». Biochem. Biophys. Res. Commun. (United States) 297 (1): 148-53. ISSN 0006-291X. PMID 12220523.

[pmid12559565-13] Umeda, M; Nishitani H; Nishimoto T (Jan. de 2003). «A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM». Gene (Netherlands) 303: 47-54. ISSN 0378-1119. PMID 12559565.