RBBP8

Proteína 8 de unión al retinoblastoma
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	RBBP8 (HGNC: 9891) CTIP; RIM
Identificadores; externos	OMIM: 604124 ; EBI: RBBP8; GeneCards: Gen RBBP8; UniProt: RBBP8;
Locus	Cr. 18 q11.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
5932
Q99708	n/a
NP_002885	n/a
	[editar datos en Wikidata]

La proteína de unión a RB 8, endonucleasa (proteína 8 de unión al retinoblastoma (RBBP8) es una proteína codificada en humanos por el gen RBBP8.

Esta proteína es expresada ubicuamente en el núcleo celular, siendo una de las muchas proteínas que se unen directamente a la proteína del retinoblastoma, y regulan la proliferación celular. RBBP8 forma un complejo con el correpresor transcripcional CTBP. También se asocia con BRCA1, probablemente para modular su función en la regulación de la transcripción, en la reparación del ADN y en los puntos de control del ciclo celular. Se ha sugerido que podría actuar como un supresor tumoral del mismo modo que BRCA1. Se han descrito tres variantes transcripcionales de este gen que codifican dos isoformas de la proteína. Existen más variantes pero no se han caracterizado completamente.

Interacciones

La proteína RBBP8 ha demostrado ser capaz de interaccionar con:

Referencias

1 2 3 4 Fusco C, Reymond A, Zervos AS (Oct de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics 51 (3): 351-8. PMID 9721205. doi:10.1006/geno.1998.5368.
↑ Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (Nov de 2007). «Human CtIP promotes DNA end resection». Nature 450 (7169): 509-14. PMC 2409435. PMID 17965729. doi:10.1038/nature06337.
1 2 «Entrez Gene: RBBP8 retinoblastoma binding protein 8».
↑ Sum, Eleanor Y M; Peng Benjamin, Yu Xin, Chen Junjie, Byrne Jennifer, Lindeman Geoffrey J, Visvader Jane E (Mar. de 2002). «The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity». J. Biol. Chem. (United States) 277 (10): 7849-56. ISSN 0021-9258. PMID 11751867. doi:10.1074/jbc.M110603200.
↑ Sutherland, Kate D; Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (Oct. de 2003). «Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas». Int. J. Cancer (United States) 107 (1): 155-8. ISSN 0020-7136. PMID 12925972. doi:10.1002/ijc.11343.
↑ Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.
1 2 Li, S; Ting N S, Zheng L, Chen P L, Ziv Y, Shiloh Y, Lee E Y, Lee W H (Jul. de 2000). «Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response». Nature (ENGLAND) 406 (6792): 210-5. ISSN 0028-0836. PMID 10910365. doi:10.1038/35018134.
↑ Kim, S T; Lim D S, Canman C E, Kastan M B (Dec. de 1999). «Substrate specificities and identification of putative substrates of ATM kinase family members». J. Biol. Chem. (UNITED STATES) 274 (53): 37538-43. ISSN 0021-9258. PMID 10608806.
↑ Dick, F A; Sailhamer E, Dyson N J (mayo. de 2000). «Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins». Mol. Cell. Biol. (UNITED STATES) 20 (10): 3715-27. ISSN 0270-7306. PMID 10779361.
1 2 Li, S; Chen P L, Subramanian T, Chinnadurai G, Tomlinson G, Osborne C K, Sharp Z D, Lee W H (Apr. de 1999). «Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage». J. Biol. Chem. (UNITED STATES) 274 (16): 11334-8. ISSN 0021-9258. PMID 10196224.
↑ Schaeper, U; Subramanian T, Lim L, Boyd J M, Chinnadurai G (Apr. de 1998). «Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif». J. Biol. Chem. (UNITED STATES) 273 (15): 8549-52. ISSN 0021-9258. PMID 9535825.
↑ Germani, Antonia; Prabel Audrey, Mourah Samia, Podgorniak Marie-Pierre, Di Carlo Anna, Ehrlich Ricardo, Gisselbrecht Sylvie, Varin-Blank Nadine, Calvo Fabien, Bruzzoni-Giovanelli Heriberto (Dec. de 2003). «SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway». Oncogene (England) 22 (55): 8845-51. ISSN 0950-9232. PMID 14654780. doi:10.1038/sj.onc.1206994.
↑ Rodriguez, Maria; Yu Xiaochun, Chen Junjie, Songyang Zhou (Dec. de 2003). «Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains». J. Biol. Chem. (United States) 278 (52): 52914-8. ISSN 0021-9258. PMID 14578343. doi:10.1074/jbc.C300407200.
↑ Wong, A K; Ormonde P A, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian S V, Teng D H, Bartel P L (Nov. de 1998). «Characterization of a carboxy-terminal BRCA1 interacting protein». Oncogene (ENGLAND) 17 (18): 2279-85. ISSN 0950-9232. PMID 9811458. doi:10.1038/sj.onc.1202150.
↑ Wu-Baer, F; Baer R (Nov. de 2001). «Effect of DNA damage on a BRCA1 complex». Nature (England) 414 (6859): 36. ISSN 0028-0836. PMID 11689934. doi:10.1038/35102118.
↑ Yu, X; Wu L C, Bowcock A M, Aronheim A, Baer R (Sep. de 1998). «The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression». J. Biol. Chem. (UNITED STATES) 273 (39): 25388-92. ISSN 0021-9258. PMID 9738006.
↑ Yu, X; Baer R (Jun. de 2000). «Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor». J. Biol. Chem. (UNITED STATES) 275 (24): 18541-9. ISSN 0021-9258. PMID 10764811. doi:10.1074/jbc.M909494199.

Enlaces externos

Literatura del gen RBBP8 a través de RARe-SOURCE
En HomoloGene: RBBP8

En Genome:RBBP8
En MalaCards.Enfermedades que coinciden con:RBBP8
En Estudio de asociación del genoma completo (GWAS) RBBP8
Búsqueda en HGNC RBBP8

Datos: Q18031058

[pmid9721205-1] 1 2 3 4 Fusco C, Reymond A, Zervos AS (Oct de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics 51 (3): 351-8. PMID 9721205. doi:10.1006/geno.1998.5368.

[pmid17965729-2] Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP (Nov de 2007). «Human CtIP promotes DNA end resection». Nature 450 (7169): 509-14. PMC 2409435. PMID 17965729. doi:10.1038/nature06337.

[entrez-3] 1 2 «Entrez Gene: RBBP8 retinoblastoma binding protein 8».

[pmid11751867-4] Sum, Eleanor Y M; Peng Benjamin, Yu Xin, Chen Junjie, Byrne Jennifer, Lindeman Geoffrey J, Visvader Jane E (Mar. de 2002). «The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity». J. Biol. Chem. (United States) 277 (10): 7849-56. ISSN 0021-9258. PMID 11751867. doi:10.1074/jbc.M110603200.

[pmid12925972-5] Sutherland, Kate D; Visvader Jane E, Choong David Y H, Sum Eleanor Y M, Lindeman Geoffrey J, Campbell Ian G (Oct. de 2003). «Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas». Int. J. Cancer (United States) 107 (1): 155-8. ISSN 0020-7136. PMID 12925972. doi:10.1002/ijc.11343.

[pmid10449734-6] Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734.

[pmid16189514-7] Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

[pmid10910365-8] 1 2 Li, S; Ting N S, Zheng L, Chen P L, Ziv Y, Shiloh Y, Lee E Y, Lee W H (Jul. de 2000). «Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response». Nature (ENGLAND) 406 (6792): 210-5. ISSN 0028-0836. PMID 10910365. doi:10.1038/35018134.

[pmid10608806-9] Kim, S T; Lim D S, Canman C E, Kastan M B (Dec. de 1999). «Substrate specificities and identification of putative substrates of ATM kinase family members». J. Biol. Chem. (UNITED STATES) 274 (53): 37538-43. ISSN 0021-9258. PMID 10608806.

[pmid10779361-10] Dick, F A; Sailhamer E, Dyson N J (mayo. de 2000). «Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins». Mol. Cell. Biol. (UNITED STATES) 20 (10): 3715-27. ISSN 0270-7306. PMID 10779361.

[pmid10196224-11] 1 2 Li, S; Chen P L, Subramanian T, Chinnadurai G, Tomlinson G, Osborne C K, Sharp Z D, Lee W H (Apr. de 1999). «Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage». J. Biol. Chem. (UNITED STATES) 274 (16): 11334-8. ISSN 0021-9258. PMID 10196224.

[pmid9535825-12] Schaeper, U; Subramanian T, Lim L, Boyd J M, Chinnadurai G (Apr. de 1998). «Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif». J. Biol. Chem. (UNITED STATES) 273 (15): 8549-52. ISSN 0021-9258. PMID 9535825.

[pmid14654780-13] Germani, Antonia; Prabel Audrey, Mourah Samia, Podgorniak Marie-Pierre, Di Carlo Anna, Ehrlich Ricardo, Gisselbrecht Sylvie, Varin-Blank Nadine, Calvo Fabien, Bruzzoni-Giovanelli Heriberto (Dec. de 2003). «SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway». Oncogene (England) 22 (55): 8845-51. ISSN 0950-9232. PMID 14654780. doi:10.1038/sj.onc.1206994.

[pmid14578343-14] Rodriguez, Maria; Yu Xiaochun, Chen Junjie, Songyang Zhou (Dec. de 2003). «Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains». J. Biol. Chem. (United States) 278 (52): 52914-8. ISSN 0021-9258. PMID 14578343. doi:10.1074/jbc.C300407200.

[pmid9811458-15] Wong, A K; Ormonde P A, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian S V, Teng D H, Bartel P L (Nov. de 1998). «Characterization of a carboxy-terminal BRCA1 interacting protein». Oncogene (ENGLAND) 17 (18): 2279-85. ISSN 0950-9232. PMID 9811458. doi:10.1038/sj.onc.1202150.

[pmid11689934-16] Wu-Baer, F; Baer R (Nov. de 2001). «Effect of DNA damage on a BRCA1 complex». Nature (England) 414 (6859): 36. ISSN 0028-0836. PMID 11689934. doi:10.1038/35102118.

[pmid9738006-17] Yu, X; Wu L C, Bowcock A M, Aronheim A, Baer R (Sep. de 1998). «The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression». J. Biol. Chem. (UNITED STATES) 273 (39): 25388-92. ISSN 0021-9258. PMID 9738006.

[pmid10764811-18] Yu, X; Baer R (Jun. de 2000). «Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor». J. Biol. Chem. (UNITED STATES) 275 (24): 18541-9. ISSN 0021-9258. PMID 10764811. doi:10.1074/jbc.M909494199.