PAX7

PAX7
Identifiants
Alias	PAX7, paired box 7
IDs externes	OMIM: 167410 MGI: 97491 HomoloGene: 55665 GeneCards: PAX7
Position du gène (humain)
Chr.	Chromosome 1 humain
Fin	18,748,866 bp
Position du gène (souris)
Chr.	Chromosome 4 (souris)
Fin	139,560,839 bp
Expression génique
	Fortement exprimé dans
	olfactory zone of nasal mucosa; ; nasal epithelium; ; muscle de la cuisse; ; testicule; ; muscle gastrocnémien; ; cortex préfrontal; ; skeletal muscle tissue; ; Brodmann area 9; ; right frontal lobe; ; gyrus cingulaire;
	Fortement exprimé dans
	colliculus supérieur; ; somite; ; dorsal tegmental nucleus; ; urètre; ; prétectum; ; main bronchus; ; hypophyse; ; poil; ; nasal placode; ; lateral nasal prominence;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	sequence-specific DNA binding; liaison ADN; DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	noyau;
Processus biologique	positive regulation of myoblast proliferation; regulation of cell fate commitment; Remodelage de la chromatine; regulation of transcription, DNA-templated; spinal cord association neuron differentiation; positive regulation of histone methylation; morphogenèse d'une structure anatomique; muscle organ development; negative regulation of apoptotic process; transcription, DNA-templated; embryonic skeletal system development; développent d'un organisme multicellulaire; cartilage development; skeletal muscle tissue regeneration; muscle tissue morphogenesis; régulation de l'expression des gènes; neuron fate commitment; skeletal muscle satellite cell commitment; dorsal/ventral neural tube patterning; regulation of protein binding; skeletal muscle tissue development; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; regulation of DNA binding;
	Sources:Amigo / QuickGO
Orthologues
	5081
	18509
	ENSG00000009709
	ENSMUSG00000028736
	P23759
	P47239
	NM_013945; NM_001135254; NM_002584
	NM_011039
	NP_001128726; NP_002575; NP_039236
	NP_035169
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La protéine paired box 7 (PAX7) est un facteur de transcription. Elle est codée par le gène PAX7 situé sur le chromosome 1 humain.

Rôles

Il est exprimé dans les cellules satellites musculaires et joue un rôle dans la différenciation de ces dernières en myoblastes, permettant en particulier le retour à un état quiescent, indifférencié. Il contribue ainsi au mécanisme de la cachexie lors d'un cancer.

Son expression est inhibée par les micro-ARN 1 et 206 et activée par le TRAF6.

Notes et références

1 2 3 GRCh38: Ensembl release 89: ENSG00000009709 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028736 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA, Pax7 is required for the specification of myogenic satellite cells, Cell, 2000;102:777–786
↑ Kuang S, Charge SB, Seale P, Huh M, Rudnicki MA, Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis, J Cell Biol, 2006;172:103–113
↑ Olguin HC, Olwin BB, Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal, Dev Biol, 2004;275:375–388
↑ He WA, Berardi E, Cardillo VM et al. NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia, J Clin Invest, 2013;123:4821–4835
↑ Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ, microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7, J Cell Biol, 2010;190:867–879
↑ Hindi SM, Kumar A, TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis, J Clin Investig, 2016;126:151-168

Portail de la biologie cellulaire et moléculaire

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000009709 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028736 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Seale_2000-5] Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA, Pax7 is required for the specification of myogenic satellite cells, Cell, 2000;102:777–786

[Kuang_2006-6] Kuang S, Charge SB, Seale P, Huh M, Rudnicki MA, Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis, J Cell Biol, 2006;172:103–113

[Olguin_2004-7] Olguin HC, Olwin BB, Pax-7 up-regulation inhibits myogenesis and cell cycle progression in satellite cells: a potential mechanism for self-renewal, Dev Biol, 2004;275:375–388

[He_2013-8] He WA, Berardi E, Cardillo VM et al. NF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia, J Clin Invest, 2013;123:4821–4835

[Chen_2010-9] Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ, microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7, J Cell Biol, 2010;190:867–879

[Hindi_2016-10] Hindi SM, Kumar A, TRAF6 regulates satellite stem cell self-renewal and function during regenerative myogenesis, J Clin Investig, 2016;126:151-168