TLE2

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La protéine de renforcement de type transductine 2 est une protéine qui est codée par le gène TLE2 chez l’homme^,.

Interactions

Il a été démontré que TLE2 interagit avec TLE1 et HES1 .

Notes et références

↑ « Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia », Genomics, vol. 31, n^o 1,‎ octobre 1996, p. 58–64 (PMID 8808280, DOI 10.1006/geno.1996.0009)
↑ « Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) »
1 2 Grbavec, Lo R, Liu Y et Stifani S, « Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development », Eur. J. Biochem., Allemagne, vol. 258, n^o 2,‎ décembre 1998, p. 339–49 (ISSN 0014-2956, PMID 9874198, DOI 10.1046/j.1432-1327.1998.2580339.x)

Bibliographie

S. Stifani, CM. Blaumueller, NJ. Redhead, et al, « Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. », Nat. Genet., vol. 2, n^o 2,‎ 1993, p. 119–27 (PMID 1303260, DOI 10.1038/ng1092-119)
H. Miyasaka H, BK. Choudhury, EW. Hou, SS. Li, « Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. », Eur. J. Biochem., vol. 216, n^o 1,‎ 1993, p. 343–52 (PMID 8365415, DOI 10.1111/j.1432-1033.1993.tb18151.x)
A. Palaparti, A. Baratz, S. Stifani, « The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. », J. Biol. Chem., vol. 272, n^o 42,‎ 1997, p. 26604–10 (PMID 9334241, DOI 10.1074/jbc.272.42.26604)
D. Grbavec, R. Lo, Y. Liu, et al, « Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. », Biochem. J., vol. 337, n^o 1,‎ 1999, p. 13–7 (PMID 9854018, PMCID 1219929, DOI 10.1042/0264-6021:3370013)
D. Grbavec, R. Lo, Y. Liu, S. Stifani, « Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. », Eur. J. Biochem., vol. 258, n^o 2,‎ 1999, p. 339–49 (PMID 9874198, DOI 10.1046/j.1432-1327.1998.2580339.x)
B. Ren, KJ. Chee, TH. Kim, T. Maniatis, « PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. », Genes Dev., vol. 13, n^o 1,‎ 1999, p. 125–37 (PMID 9887105, PMCID 316372, DOI 10.1101/gad.13.1.125)
A. Javed, B. Guo, S. Hiebert, et al, « Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription. », J. Cell Sci., vol. 113, n^o 12,‎ 2000, p. 2221–31 (PMID 10825294)
H. Brantjes, J. Roose, M. van De Wetering, H. Clevers, « All Tcf HMG box transcription factors interact with Groucho-related co-repressors. », Nucleic Acids Res., vol. 29, n^o 7,‎ 2001, p. 1410–9 (PMID 11266540, PMCID 31284, DOI 10.1093/nar/29.7.1410)
A. Dintilhac, J. Bernués, « HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. », J. Biol. Chem., vol. 277, n^o 9,‎ 2002, p. 7021–8 (PMID 11748221, DOI 10.1074/jbc.M108417200, lire en ligne)
RL. Strausberg, EA. Feingold, LH. Grouse, et al, « Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. », Proc. Natl. Acad. Sci. U.S.A., vol. 99, n^o 26,‎ 2003, p. 16899–903 (PMID 12477932, PMCID 139241, DOI 10.1073/pnas.242603899, Bibcode 2002PNAS...9916899M)
T. Ota, Y. Suzuki, T. Nishikawa, et al, « Complete sequencing and characterization of 21,243 full-length human cDNAs. », Nat. Genet., vol. 36, n^o 1,‎ 2004, p. 40–5 (PMID 14702039, DOI 10.1038/ng1285)
J. Grimwood, LA. Gordon, A. Olsen, et al, « The DNA sequence and biology of human chromosome 19. », Nature, vol. 428, n^o 6982,‎ 2004, p. 529–35 (PMID 15057824, DOI 10.1038/nature02399, Bibcode 2004Natur.428..529G)
DS. Gerhard, L. Wagner, EA. Feingold, et al, « The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). », Genome Res., vol. 14, n^o 10B,‎ 2004, p. 2121–7 (PMID 15489334, PMCID 528928, DOI 10.1101/gr.2596504)
JF. Rual, K. Venkatesan, T. Hao, et al, « Towards a proteome-scale map of the human protein-protein interaction network. », Nature, vol. 437, n^o 7062,‎ 2005, p. 1173–8 (PMID 16189514, DOI 10.1038/nature04209, Bibcode 2005Natur.437.1173R)
LA. Higa, M. Wu, T. Ye, et al, « CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. », Nat. Cell Biol., vol. 8, n^o 11,‎ 2006, p. 1277–83 (PMID 17041588, DOI 10.1038/ncb1490)

Liens externes

Ressource relative à la santé :
- Héritage mendélien chez l'humain

Portail de la biologie cellulaire et moléculaire

[pmid8808280-1] « Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia », Genomics, vol. 31, n^o 1,‎ octobre 1996, p. 58–64 (PMID 8808280, DOI 10.1006/geno.1996.0009)

[entrez-2] « Entrez Gene: TLE2 transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) »

[pmid9874198-3] 1 2 Grbavec, Lo R, Liu Y et Stifani S, « Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development », Eur. J. Biochem., Allemagne, vol. 258, n^o 2,‎ décembre 1998, p. 339–49 (ISSN 0014-2956, PMID 9874198, DOI 10.1046/j.1432-1327.1998.2580339.x)