YY1

YY1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1UBD, 1ZNM, 4C5I
識別子
記号	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
外部ID	OMIM: 600013 MGI: 99150 HomoloGene: 2556 GeneCards: YY1
遺伝子の位置 (ヒト)
染色体	14番染色体 (ヒト)
終点	100,282,788 bp
遺伝子の位置 (マウス)
染色体	12番染色体 (マウス)
終点	108,786,074 bp
RNA発現パターン
	; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• DNA結合; • transcription corepressor activity; • transcription coactivator activity; • zinc ion binding; • 金属イオン結合; • 血漿タンパク結合; • four-way junction DNA binding; • cis-regulatory region sequence-specific DNA binding; • RNA結合; • 核酸結合; • SMAD binding; • RNA polymerase II cis-regulatory region sequence-specific DNA binding; • DNA-binding transcription repressor activity, RNA polymerase II-specific; • DNA-binding transcription factor activity; • sequence-specific DNA binding; • DNA-binding transcription factor activity, RNA polymerase II-specific; • ヒストンデアセチラーゼ結合;
細胞の構成要素	• INO80サブファミリー; • 核マトリックス; • 細胞核; • 核質; • transcription regulator complex; • 細胞質; • PcG protein complex;
生物学的プロセス	• 細胞分化; • DNA recombination; • regulation of transcription, DNA-templated; • regulation of transcription by RNA polymerase II; • cellular response to UV; • 遺伝子発現の負の調節; • transcription, DNA-templated; • DNA損傷刺激に対する細胞応答; • double-strand break repair via homologous recombination; • 精子発生; • DNA修復; • protein deubiquitination; • negative regulation of interferon-beta production; • negative regulation of transcription by RNA polymerase II; • RNA localization; • anterior/posterior pattern specification; • response to UV-C; • positive regulation of gene expression; • response to prostaglandin F; • positive regulation of transcription by RNA polymerase II; • camera-type eye morphogenesis; • 染色体構成; • cellular response to interleukin-1; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of cell growth involved in cardiac muscle cell development;
	出典:Amigo / QuickGO
オルソログ
	7528
	22632
	ENSG00000100811
	ENSMUSG00000021264
	P25490,G3V3M8
	Q00899
	NM_003403
	NM_009537
	NP_003394
	NP_033563
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

YY1（Yin Yang 1）は、ヒトではYY1遺伝子にコードされる転写因子である。

機能

YY1は生体内に遍在的に分布している転写因子であり、GLI-Kruppel型のジンクフィンガータンパク質に属する。このタンパク質は多様なプロモーターの抑制と活性化に関与している。YYは「陰陽」を意味している。YY1はプロモーターの活性化または抑制のためにヒストンデアセチラーゼやヒストンアセチルトランスフェラーゼをリクルートしている可能性があり、ヒストン修飾における機能が示唆されている。YY1は二量体を形成してDNA相互作用を促進し、エンハンサー-プロモーター間のクロマチンループの形成を促進する。YY1の調節異常によってエンハンサー-プロモーター間のループ形成が損なわれ、遺伝子発現が損なわれる。

臨床的意義

YY1遺伝子のヘテロ接合型の欠失、ミスセンス変異、ナンセンス変異は、常染色体優性型の神経発達障害であるGabriele-de Vries症候群（GADEVS）を引き起こす。この疾患は、知的障害、顔面形態異常、摂食障害、子宮内発育遅延、さまざまな認知機能障害、行動障害、その他の先天性奇形を特徴とする。また、臨床医と患者の家族との間で臨床情報を収集・共有するためのウェブサイトが利用可能である。

相互作用

YY1は次に挙げる因子と相互作用することが示されている。

出典

1 2 3 GRCh38: Ensembl release 89: ENSG00000100811 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017
↑ Human PubMed Reference:
↑ Mouse PubMed Reference:
↑ “Oncogenic potential of yin yang 1 mediated through control of imprinted genes”. Critical Reviews in Oncogenesis 16 (3–4): 199–209. (2011). doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
↑ “Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein”. Cell 67 (2): 377–88. (Oct 1991). doi:10.1016/0092-8674(91)90189-6. PMID 1655281.
↑ “Chromosomal localization of the transcription factor YY1 in the mouse and human”. Mammalian Genome 5 (4): 234–6. (Apr 1994). doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122.
↑ “Entrez Gene: YY1 YY1 transcription factor”. 2021年10月15日閲覧。
↑ “YY1 Is a Structural Regulator of Enhancer-Promoter Loops”. Cell 171 (7): 1573–1588.e28. (December 2017). doi:10.1016/j.cell.2017.11.008. PMC 5785279. PMID 29224777.
↑ “YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction”. American Journal of Human Genetics 100 (6): 907–925. (June 2017). doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.
↑ “OMIM:GABRIELE-DE VRIES SYNDROME”. 2021年10月15日閲覧。
↑ Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E. et al. (1993). Gabriele-de Vries Syndrome. PMID 31145572.
↑ “YY1 - Collect information about clinic management and research projects” (英語). YY1. 2021年10月15日閲覧。
↑ “ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1”. Molecular and Cellular Biology 20 (14): 5096–106. (Jul 2000). doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.
1 2 3 “Regulation of transcription factor YY1 by acetylation and deacetylation”. Molecular and Cellular Biology 21 (17): 5979–91. (Sep 2001). doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
↑ “Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300”. Genes & Development 9 (10): 1188–98. (May 1995). doi:10.1101/gad.9.10.1188. PMID 7758944.
↑ “The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1”. The EMBO Journal 20 (17): 4814–25. (Sep 2001). doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.
1 2 “Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family”. The Journal of Biological Chemistry 272 (44): 28001–7. (Oct 1997). doi:10.1074/jbc.272.44.28001. PMID 9346952.
↑ “Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1”. Nucleic Acids Research 25 (4): 843–9. (Feb 1997). doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
↑ “Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc”. Science 262 (5141): 1889–92. (Dec 1993). Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.
↑ “Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch”. The Journal of Biological Chemistry 278 (43): 41963–9. (Oct 2003). doi:10.1074/jbc.M304353200. PMID 12913000.
↑ “RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1”. The EMBO Journal 18 (12): 3404–18. (Jun 1999). doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.
↑ “Modulation of YY1 activity by SAP30”. Biochemical and Biophysical Research Communications 306 (1): 267–75. (Jun 2003). doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.
↑ “Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis”. Nucleic Acids Research 45 (5): 2423–2437. (Nov 2017). doi:10.1093/nar/gkw1187. PMC 5389716. PMID 27913726.

外部リンク

FactorBook YY1
Overview of all the structural information available in the PDB for UniProt: P25490 (Transcriptional repressor protein YY1) at the PDBe-KB.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100811 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021264 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[:0-5] “Oncogenic potential of yin yang 1 mediated through control of imprinted genes”. Critical Reviews in Oncogenesis 16 (3–4): 199–209. (2011). doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.

[pmid1655281-6] “Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein”. Cell 67 (2): 377–88. (Oct 1991). doi:10.1016/0092-8674(91)90189-6. PMID 1655281.

[pmid7912122-7] “Chromosomal localization of the transcription factor YY1 in the mouse and human”. Mammalian Genome 5 (4): 234–6. (Apr 1994). doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122.

[:1-8] “Entrez Gene: YY1 YY1 transcription factor”. 2021年10月15日閲覧。

[:2-9] “YY1 Is a Structural Regulator of Enhancer-Promoter Loops”. Cell 171 (7): 1573–1588.e28. (December 2017). doi:10.1016/j.cell.2017.11.008. PMC 5785279. PMID 29224777.

[YY1_Haploinsufficiency_Causes_an_Intellectual_Disability_Syndrome_Featuring_Transcriptional_and_Chromatin_Dysfunction.-10] “YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction”. American Journal of Human Genetics 100 (6): 907–925. (June 2017). doi:10.1016/j.ajhg.2017.05.006. PMC 5473733. PMID 28575647.

[:3-11] “OMIM:GABRIELE-DE VRIES SYNDROME”. 2021年10月15日閲覧。

[:4-12] Nabais Sá, M. J.; Gabriele, M.; Testa, G.; de Vries BBA; Adam, M. P.; Ardinger, H. H.; Pagon, R. A.; Wallace, S. E. et al. (1993). Gabriele-de Vries Syndrome. PMID 31145572.

[13] “YY1 - Collect information about clinic management and research projects” (英語). YY1. 2021年10月15日閲覧。

[pmid10866666-14] “ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1”. Molecular and Cellular Biology 20 (14): 5096–106. (Jul 2000). doi:10.1128/mcb.20.14.5096-5106.2000. PMC 85959. PMID 10866666.

[pmid11486036-15] 1 2 3 “Regulation of transcription factor YY1 by acetylation and deacetylation”. Molecular and Cellular Biology 21 (17): 5979–91. (Sep 2001). doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.

[pmid7758944-16] “Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300”. Genes & Development 9 (10): 1188–98. (May 1995). doi:10.1101/gad.9.10.1188. PMID 7758944.

[pmid11532945-17] “The FK506-binding protein 25 functionally associates with histone deacetylases and with transcription factor YY1”. The EMBO Journal 20 (17): 4814–25. (Sep 2001). doi:10.1093/emboj/20.17.4814. PMC 125595. PMID 11532945.

[pmid9346952-18] 1 2 “Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family”. The Journal of Biological Chemistry 272 (44): 28001–7. (Oct 1997). doi:10.1074/jbc.272.44.28001. PMID 9346952.

[pmid9016636-19] “Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1”. Nucleic Acids Research 25 (4): 843–9. (Feb 1997). doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.

[pmid8266081-20] “Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc”. Science 262 (5141): 1889–92. (Dec 1993). Bibcode:1993Sci...262.1889S. doi:10.1126/science.8266081. PMID 8266081.

[pmid12913000-21] “Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch”. The Journal of Biological Chemistry 278 (43): 41963–9. (Oct 2003). doi:10.1074/jbc.M304353200. PMID 12913000.

[pmid10369680-22] “RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1”. The EMBO Journal 18 (12): 3404–18. (Jun 1999). doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

[huang-23] “Modulation of YY1 activity by SAP30”. Biochemical and Biophysical Research Communications 306 (1): 267–75. (Jun 2003). doi:10.1016/s0006-291x(03)00966-5. PMID 12788099.

[fu-24] “Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis”. Nucleic Acids Research 45 (5): 2423–2437. (Nov 2017). doi:10.1093/nar/gkw1187. PMC 5389716. PMID 27913726.

YY1

機能

臨床的意義

相互作用

出典

関連文献

外部リンク