CXCR4

C-X-C motif chemokine receptor 4
Identificadores
Nomes alternativos
IDs externos	GeneCards:
Padrão de expressão RNA
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	Wikidata
Ver/Editar Humano

CXCR-4 (C-X-C chemokine receptor type 4) ou CD184 (cluster of differentiation 184) é uma proteína que nos humanos é codificada pelo gene CXCR4.

Técnica CRISPR

Usando CRISPR, pesquisadores foram capazes de converter a proteína CXCR4 na superfície das células T do sistema imunológico, de uma forma que as células geneticamente modificadas não eram mais propensas a ataques pelo vírus HIV.

Referências

↑ Moriuchi M, Moriuchi H, Turner W, Fauci AS (1997). «Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry». J. Immunol. 159 (9): 4322–9. PMID 9379028
↑ Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (1998). «Genomic organization and promoter characterization of human CXCR4 gene». FEBS Lett. 426 (2): 271–8. PMID 9599023
↑ «Breakthrough announced in 'editing' DNA to fight off deadly illness». Consultado em 30 de julho de 2015

Leitura de apoio

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[pmid9379028-1] Moriuchi M, Moriuchi H, Turner W, Fauci AS (1997). «Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry». J. Immunol. 159 (9): 4322–9. PMID 9379028

[pmid9599023-2] Caruz A, Samsom M, Alonso JM, Alcami J, Baleux F, Virelizier JL, Parmentier M, Arenzana-Seisdedos F (1998). «Genomic organization and promoter characterization of human CXCR4 gene». FEBS Lett. 426 (2): 271–8. PMID 9599023

[3] «Breakthrough announced in 'editing' DNA to fight off deadly illness». Consultado em 30 de julho de 2015