E2F3

E2F3
Identificadores
Nomes alternativos	E2F3
IDs externos	OMIM: 600427 HomoloGene: 74413 GeneCards: E2F3
Ontologia genética
Função molecular	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • protein dimerization activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • transcription factor binding;
Componente celular	• núcleo celular; • transcription regulator complex; • RNA polymerase II transcription regulator complex; • cariolinfa;
Processo biológico	• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of fat cell proliferation; • ciclo celular; • transcription initiation from RNA polymerase II promoter; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • positive regulation of cell population proliferation; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of vascular associated smooth muscle cell apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • regulation of cell cycle;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	1871
	n/a
	ENSG00000112242
	n/a
	O00716
	n/a
	NM_001243076; NM_001949
	n/a
	NP_001230005; NP_001940
	n/a
	Wikidata
Ver/Editar Humano

O fator de transcrição E2F3 é uma proteína que em humanos é codificada pelo gene E2F3.

Função

A proteína codificada por este gene é um membro da família E2F de fatores de transcrição. A família E2F desempenha um papel crucial no controle do ciclo celular e na ação de proteínas supressoras de tumor e também é um alvo das proteínas transformadoras de pequenos vírus tumorais de DNA. Esta proteína liga-se especificamente à proteína de retinoblastoma pRB de um modo dependente do ciclo celular. A emenda genética alternativa é encontrado no homólogo de camundongos, mas ainda não foi relatado em humanos.

Referências

↑ «Human PubMed Reference:»
↑ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (dezembro de 1993). «The retinoblastoma protein binds to a family of E2F transcription factors». Molecular and Cellular Biology. 13 (12): 7813–25. PMC 364853. PMID 8246996. doi:10.1128/mcb.13.12.7813
↑ «Entrez Gene: E2F3 E2F transcription factor 3»

Leitura adicional

Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). «Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1». DNA Research. 1 (5): 223–9. PMID 7584044. doi:10.1093/dnares/1.5.223
Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA (maio de 1995). «In vivo association of E2F and DP family proteins». Molecular and Cellular Biology. 15 (5): 2536–46. PMC 230484. PMID 7739537. doi:10.1128/mcb.15.5.2536
Karlseder J, Rotheneder H, Wintersberger E (abril de 1996). «Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F». Molecular and Cellular Biology. 16 (4): 1659–67. PMC 231152. PMID 8657141. doi:10.1128/mcb.16.4.1659
Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM (julho de 1996). «DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo». Proceedings of the National Academy of Sciences of the United States of America. 93 (15): 7594–9. PMC 38791. PMID 8755520. doi:10.1073/pnas.93.15.7594
Magae J, Wu CL, Illenye S, Harlow E, Heintz NH (julho de 1996). «Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members». Journal of Cell Science. 109 (7): 1717–26. PMID 8832394
Hofmann F, Livingston DM (abril de 1996). «Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit». Genes & Development. 10 (7): 851–61. PMID 8846921. doi:10.1101/gad.10.7.851
Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (maio de 1997). «The subcellular localization of E2F-4 is cell-cycle dependent». Proceedings of the National Academy of Sciences of the United States of America. 94 (10): 5095–100. PMC 24637. PMID 9144196. doi:10.1073/pnas.94.10.5095
Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L (julho de 1997). «Specific regulation of E2F family members by cyclin-dependent kinases». Molecular and Cellular Biology. 17 (7): 3867–75. PMC 232239. PMID 9199321. doi:10.1128/mcb.17.7.3867
Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG (julho de 1998). «Differential activities of E2F family members: unique functions in regulating transcription». Molecular Carcinogenesis. 22 (3): 190–8. PMID 9688145. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P
Humbert PO, Verona R, Trimarchi JM, Rogers C, Dandapani S, Lees JA (março de 2000). «E2f3 is critical for normal cellular proliferation». Genes & Development. 14 (6): 690–703. PMC 316459. PMID 10733529
Takahashi Y, Rayman JB, Dynlacht BD (abril de 2000). «Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression». Genes & Development. 14 (7): 804–16. PMC 316494. PMID 10766737. doi:10.1101/gad.14.7.804 (inativo 17 de fevereiro de 2019)
Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A, Nevins JR (maio de 2000). «Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins». Molecular and Cellular Biology. 20 (10): 3626–32. PMC 85655. PMID 10779352. doi:10.1128/MCB.20.10.3626-3632.2000
He Y, Armanious MK, Thomas MJ, Cress WD (julho de 2000). «Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region». Oncogene. 19 (30): 3422–33. PMID 10918599. doi:10.1038/sj.onc.1203682
Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M (dezembro de 2001). «ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)». European Journal of Biochemistry / FEBS. 268 (23): 6076–82. PMID 11733001. doi:10.1046/j.0014-2956.2001.02555.x
Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ (janeiro de 2002). «Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis». Genes & Development. 16 (2): 235–44. PMC 155318. PMID 11799066. doi:10.1101/gad.943102
Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD (janeiro de 2002). «E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints». Genes & Development. 16 (2): 245–56. PMC 155321. PMID 11799067. doi:10.1101/gad.949802
He Y, Cress WD (junho de 2002). «E2F-3B is a physiological target of cyclin A». The Journal of Biological Chemistry. 277 (26): 23493–9. PMID 11980909. doi:10.1074/jbc.M202629200
Schlisio S, Halperin T, Vidal M, Nevins JR (novembro de 2002). «Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function». The EMBO Journal. 21 (21): 5775–86. PMC 131074. PMID 12411495. doi:10.1093/emboj/cdf577

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[1] «Human PubMed Reference:»

[pmid8246996-2] Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (dezembro de 1993). «The retinoblastoma protein binds to a family of E2F transcription factors». Molecular and Cellular Biology. 13 (12): 7813–25. PMC 364853. PMID 8246996. doi:10.1128/mcb.13.12.7813

[entrez-3] «Entrez Gene: E2F3 E2F transcription factor 3»