GOPC

GOPC
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	2DC2, 2LOB, 4E34, 4E35, 4JOE, 4JOF, 4JOG, 4JOH, 4JOJ, 4JOK, 4JOP, 4JOR, 4K6Y, 4K72, 4K75, 4K76, 4K78, 4NMO, 4NMP, 4NMQ, 4NMR, 4NMS, 4NMT, 4NMV, 4Q6H, 4Q6S
Identificadores
Nomes alternativos	GOPC
IDs externos	OMIM: 606845 HomoloGene: 10695 GeneCards: GOPC
Ontologia genética
Função molecular	• transmembrane transporter binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • GO:0005110 frizzled binding; • protein C-terminus binding; • GO:0005083 GTPase regulator activity; • protein homodimerization activity;
Componente celular	• lysosomal membrane; • Golgi-associated vesicle membrane; • trans-Golgi network transport vesicle; • sinapse; • cell projection; • junção celular; • Golgi membrane; • GO:0097483, GO:0097481 postsynaptic density; • membrana pós-sináptica; • dendrito; • membrane; • complexo de Golgi; • citoplasma; • membrana plasmática; • GO:0009327 complexo macromolecular;
Processo biológico	• endoplasmic reticulum to Golgi vesicle-mediated transport; • protein homooligomerization; • apical protein localization; • protein transport; • Golgi to plasma membrane transport; • negative regulation of anion channel activity; • cytoplasmic sequestering of CFTR protein; • negative regulation of protein localization to cell surface; • spermatid nucleus differentiation; • GO:0048552 regulation of catalytic activity;
	Sources:Amigo / QuickGO
Ortólogos
	57120
	n/a
	ENSG00000047932
	n/a
	Q9HD26
	n/a
	NM_020399; NM_001017408
	n/a
	NP_001017408; NP_065132
	n/a
	Wikidata
Ver/Editar Humano

A PDZ associada ao Golgi e proteína contendo motivo espiralado é uma proteína que em humanos é codificada pelo gene GOPC.

PIST é uma proteína de Golgi contendo o domínio PDZ. Os domínios PDZ contêm aproximadamente 90 aminoácidos e ligam o terminal C extremo de proteínas de uma maneira específica da seqüência.

Interações

O GOPC demonstrou interagir com GRID2, BECN1, RHOQ,ACCN3, CFTR e CSPG5.

Referências

↑ «Human PubMed Reference:»
1 2 Neudauer CL, Joberty G, Macara IG (fevereiro de 2001). «PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10». Biochem Biophys Res Commun. 280 (2): 541–7. PMID 11162552. doi:10.1006/bbrc.2000.4160
↑ Yao R, Maeda T, Takada S, Noda T (agosto de 2001). «Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled». Biochem Biophys Res Commun. 286 (4): 771–8. PMID 11520064. doi:10.1006/bbrc.2001.5430
1 2 «Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing»
1 2 Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (agosto de 2002). «A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice». United States. Neuron. 35 (5): 921–33. ISSN 0896-6273. PMID 12372286. doi:10.1016/S0896-6273(02)00861-9
↑ Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (novembro de 2004). «PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current». United States. J. Biol. Chem. 279 (45): 46962–8. ISSN 0021-9258. PMID 15317815. doi:10.1074/jbc.M405874200
↑ Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (fevereiro de 2002). «A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression». United States. J. Biol. Chem. 277 (5): 3520–9. ISSN 0021-9258. PMID 11707463. doi:10.1074/jbc.M110177200
↑ Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (fevereiro de 2003). «The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins». United States. J. Biol. Chem. 278 (8): 6440–9. ISSN 0021-9258. PMID 12471024. doi:10.1074/jbc.M211050200
↑ Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (outubro de 2003). «CALEB/NGC interacts with the Golgi-associated protein PIST». United States. J. Biol. Chem. 278 (41): 40136–43. ISSN 0021-9258. PMID 12885772. doi:10.1074/jbc.M305577200

Leitura adicional

Loo MA, Jensen TJ, Cui L, et al. (1999). «Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome». EMBO J. 17 (23): 6879–87. PMC 1171036. PMID 9843494. doi:10.1093/emboj/17.23.6879
Charest A, Lane K, McMahon K, Housman DE (2001). «Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6». J. Biol. Chem. 276 (31): 29456–65. PMID 11384996. doi:10.1074/jbc.M104137200
Cheng J, Moyer BD, Milewski M, et al. (2002). «A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression». J. Biol. Chem. 277 (5): 3520–9. PMID 11707463. doi:10.1074/jbc.M110177200
Yao R, Ito C, Natsume Y, et al. (2002). «Lack of acrosome formation in mice lacking a Golgi protein, GOPC». Proc. Natl. Acad. Sci. U.S.A. 99 (17): 11211–6. PMC 123235. PMID 12149515. doi:10.1073/pnas.162027899
Yue Z, Horton A, Bravin M, et al. (2002). «A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice». Neuron. 35 (5): 921–33. PMID 12372286. doi:10.1016/S0896-6273(02)00861-9
Gentzsch M, Cui L, Mengos A, et al. (2003). «The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins». J. Biol. Chem. 278 (8): 6440–9. PMID 12471024. doi:10.1074/jbc.M211050200
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Charest A, Kheifets V, Park J, et al. (2003). «Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma». Proc. Natl. Acad. Sci. U.S.A. 100 (3): 916–21. PMC 298701. PMID 12538861. doi:10.1073/pnas.242741799
Charest A, Lane K, McMahon K, et al. (2003). «Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)». Genes Chromosomes Cancer. 37 (1): 58–71. PMID 12661006. doi:10.1002/gcc.10207
Hassel B, Schreff M, Stube EM, et al. (2003). «CALEB/NGC interacts with the Golgi-associated protein PIST». J. Biol. Chem. 278 (41): 40136–43. PMID 12885772. doi:10.1074/jbc.M305577200
Cheng J, Wang H, Guggino WB (2004). «Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL». J. Biol. Chem. 279 (3): 1892–8. PMID 14570915. doi:10.1074/jbc.M308640200
Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
Brill LM, Salomon AR, Ficarro SB, et al. (2004). «Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry». Anal. Chem. 76 (10): 2763–72. PMID 15144186. doi:10.1021/ac035352d
Hruska-Hageman AM, Benson CJ, Leonard AS, et al. (2004). «PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current». J. Biol. Chem. 279 (45): 46962–8. PMID 15317815. doi:10.1074/jbc.M405874200
He J, Bellini M, Xu J, et al. (2005). «Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression». J. Biol. Chem. 279 (48): 50190–6. PMID 15358775. doi:10.1074/jbc.M404876200
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Cheng J, Wang H, Guggino WB (2005). «Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10». J. Biol. Chem. 280 (5): 3731–9. PMID 15546864. doi:10.1074/jbc.M410026200
Hicks SW, Machamer CE (2005). «Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST». J. Biol. Chem. 280 (32): 28944–51. PMID 15951434. doi:10.1074/jbc.M504937200

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[1] «Human PubMed Reference:»

[pmid11162552-2] 1 2 Neudauer CL, Joberty G, Macara IG (fevereiro de 2001). «PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10». Biochem Biophys Res Commun. 280 (2): 541–7. PMID 11162552. doi:10.1006/bbrc.2000.4160

[pmid11520064-3] Yao R, Maeda T, Takada S, Noda T (agosto de 2001). «Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled». Biochem Biophys Res Commun. 286 (4): 771–8. PMID 11520064. doi:10.1006/bbrc.2001.5430

[entrez-4] 1 2 «Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing»

[pmid12372286-5] 1 2 Yue, Zhenyu; Horton Antony; Bravin Monica; DeJager Philip L; Selimi Fekrije; Heintz Nathaniel (agosto de 2002). «A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice». United States. Neuron. 35 (5): 921–33. ISSN 0896-6273. PMID 12372286. doi:10.1016/S0896-6273(02)00861-9

[pmid15317815-6] Hruska-Hageman, Alesia M; Benson Christopher J; Leonard A Soren; Price Margaret P; Welsh Michael J (novembro de 2004). «PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current». United States. J. Biol. Chem. 279 (45): 46962–8. ISSN 0021-9258. PMID 15317815. doi:10.1074/jbc.M405874200

[pmid11707463-7] Cheng, Jie; Moyer Bryan D; Milewski Michal; Loffing Johannes; Ikeda Masahiro; Mickle John E; Cutting Garry R; Li Min; Stanton Bruce A; Guggino William B (fevereiro de 2002). «A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression». United States. J. Biol. Chem. 277 (5): 3520–9. ISSN 0021-9258. PMID 11707463. doi:10.1074/jbc.M110177200

[pmid12471024-8] Gentzsch, Martina; Cui Liying; Mengos April; Chang Xiu-Bao; Chen Jey-Hsin; Riordan John R (fevereiro de 2003). «The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins». United States. J. Biol. Chem. 278 (8): 6440–9. ISSN 0021-9258. PMID 12471024. doi:10.1074/jbc.M211050200

[pmid12885772-9] Hassel, Burkhard; Schreff Matthias; Stube Eva-Maria; Blaich Uta; Schumacher Stefan (outubro de 2003). «CALEB/NGC interacts with the Golgi-associated protein PIST». United States. J. Biol. Chem. 278 (41): 40136–43. ISSN 0021-9258. PMID 12885772. doi:10.1074/jbc.M305577200