HMGA1

HMGA1 (do inglês High mobility group AT-hook 1) é uma proteína que é codificada pelo gene humano HMGA1.

Este gene codifica uma proteína não-histónica envolvida em muitos processos celulares, incluindo a regulação de transcrição genética induzível, integração de retrovírus em cromossomas e a progressão de metástases.

A proteína codificada liga-se preferencialmente ao sulco menor de regiões ricas em A+T, em ADN de fita dupla. Tem pouca estrutura secundária em solução mas assume diferentes conformações quando ligada a substratos como ADN e outras proteínas.

A proteína codificada é frequentemente acetilada e encontrada no núcleo celular.

Ratos que não possuem este gene desenvolvem um fenótipo de diabetes tipo 2.

Leitura adicional

Reeves R, Beckerbauer L (2001). «HMGI/Y proteins: flexible regulators of transcription and chromatin structure.». Biochim. Biophys. Acta. 1519 (1-2): 13–29. PMID 11406267
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Leger H, Sock E, Renner K; et al. (1995). «Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.». Mol. Cell. Biol. 15 (7): 3738–47. PMID 7791781
John S, Reeves RB, Lin JX; et al. (1995). «Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.». Mol. Cell. Biol. 15 (3): 1786–96. PMID 7862168
Friedmann M, Holth LT, Zoghbi HY, Reeves R (1993). «Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene.». Nucleic Acids Res. 21 (18): 4259–67. PMID 8414980. doi:10.1093/nar/21.18.4259
Farnet CM, Bushman FD (1997). «HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro.». Cell. 88 (4): 483–92. PMID 9038339. doi:10.1016/S0092-8674(00)81888-7
Miller MD, Farnet CM, Bushman FD (1997). «Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition.». J. Virol. 71 (7): 5382–90. PMID 9188609
Huth JR, Bewley CA, Nissen MS; et al. (1997). «The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.». Nat. Struct. Biol. 4 (8): 657–65. PMID 9253416. doi:10.1038/nsb0897-657
Currie RA (1998). «Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y).». J. Biol. Chem. 272 (49): 30880–8. PMID 9388234. doi:10.1074/jbc.272.49.30880
Chin MT, Pellacani A, Wang H; et al. (1998). «Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).». J. Biol. Chem. 273 (16): 9755–60. PMID 9545312. doi:10.1074/jbc.273.16.9755
Chiappetta G, Tallini G, De Biasio MC; et al. (1998). «Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.». Cancer Res. 58 (18): 4193–8. PMID 9751634

Referências

↑ Friedmann M, Holth LT, Zoghbi HY, Reeves R (1993). «Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene». Nucleic Acids Res. 21 (18): 4259–67. PMC 310059. PMID 8414980. doi:10.1093/nar/21.18.4259
↑ Reeves R, Beckerbauer L (2001). «HMGI/Y proteins: flexible regulators of transcription and chromatin structure». Biochim Biophys Acta. 1519 (1-2): 13–29. PMID 11406267
↑ «Entrez Gene: HMGA1 high mobility group AT-hook 1»

Ligações externas

MeSH HMGA1+protein,+human

[pmid8414980-1] Friedmann M, Holth LT, Zoghbi HY, Reeves R (1993). «Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene». Nucleic Acids Res. 21 (18): 4259–67. PMC 310059. PMID 8414980. doi:10.1093/nar/21.18.4259

[pmid11406267-2] Reeves R, Beckerbauer L (2001). «HMGI/Y proteins: flexible regulators of transcription and chromatin structure». Biochim Biophys Acta. 1519 (1-2): 13–29. PMID 11406267

[entrez-3] «Entrez Gene: HMGA1 high mobility group AT-hook 1»