ITPR1

Inositol 1,4,5-trisphosphate receptor, type 1
	PDB rendering based on 1n4k.
Estruturas disponíveis
PDB	Busca de ortólogos: PDBe, RCSB
Lista de códigos PDB
	1n4k, 1xzz
Identificadores
Símbolos	ITPR1; ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29
IDs externos	OMIM: 147265 MGI: 96623 HomoloGene: 1673 IUPHAR: IP3R1 ChEMBL: 4046 GeneCards: ITPR1 Gene
Ontologia do gene
Função molecular	•intracellular ligand-gated calcium channel activity; •inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; •protein binding; •calcium ion transmembrane transporter activity; •phosphatidylinositol binding;
Componente celular	•nuclear inner membrane; •nucleolus; •endoplasmic reticulum; •endoplasmic reticulum membrane; •calcineurin complex; •postsynaptic density; •membrane; •integral component of membrane; •sarcoplasmic reticulum; •platelet dense granule membrane; •platelet dense tubular network; •platelet dense tubular network membrane;
Processo biológico	•response to hypoxia; •energy reserve metabolic process; •calcium ion transport; •signal transduction; •epidermal growth factor receptor signaling pathway; •activation of phospholipase C activity; •blood coagulation; •fibroblast growth factor receptor signaling pathway; •post-embryonic development; •platelet activation; •endoplasmic reticulum calcium ion homeostasis; •Fc-epsilon receptor signaling pathway; •Fc-gamma receptor signaling pathway involved in phagocytosis; •small molecule metabolic process; •innate immune response; •neurotrophin TRK receptor signaling pathway; •inositol phosphate-mediated signaling; •regulation of insulin secretion; •voluntary musculoskeletal movement; •release of sequestered calcium ion into cytosol; •intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; •calcium ion transmembrane transport;
	Sources: Amigo / QuickGO
Padrões de expressão do ARN
	Mais dados de expressão
Ortólogos
	v; d; e;

ITPR1 (do inglês, inositol 1,4,5-triphosphate receptor, type 1) é uma proteína que é codificada pelo gene humano ITPR1.

Ver também

Referências

↑ Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guenet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T; et al. (1994). «Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization». Biochem J. 302 ( Pt 3): 781–90. PMC 1137299. PMID 7945203
↑ Nucifora FC Jr, Li SH, Danoff S, Ullrich A, Ross CA (1996). «Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant». Brain Res Mol Brain Res. 32 (2): 291–6. PMID 7500840. doi:10.1016/0169-328X(95)00089-B
↑ van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (2007). «Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans». PLoS Genet. 3 (6): e108. PMC 1892049. PMID 17590087. doi:10.1371/journal.pgen.0030108
↑ Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (2008). «Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16». J Med Genet. 45 (1): 32–5. PMID 17932120. doi:10.1136/jmg.2007.053942
↑ «Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1»

Leitura de apoio

Stove V, Verhasselt B (2006). «Modelling thymic HIV-1 Nef effects.». Curr. HIV Res. 4 (1): 57–64. PMID 16454711. doi:10.2174/157016206775197583
Joseph SK, Lin C, Pierson S; et al. (1995). «Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.». J. Biol. Chem. 270 (40): 23310–6. PMID 7559486. doi:10.1074/jbc.270.40.23310
Harnick DJ, Jayaraman T, Ma Y; et al. (1995). «The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.». J. Biol. Chem. 270 (6): 2833–40. PMID 7852357. doi:10.1074/jbc.270.6.2833
Wojcikiewicz RJ, Furuichi T, Nakade S; et al. (1994). «Muscarinic receptor activation down-regulates the type I inositol 1,4,5-trisphosphate receptor by accelerating its degradation.». J. Biol. Chem. 269 (11): 7963–9. PMID 8132516
Komalavilas P, Lincoln TM (1994). «Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.». J. Biol. Chem. 269 (12): 8701–7. PMID 8132598
Cameron AM, Steiner JP, Roskams AJ; et al. (1996). «Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux.». Cell. 83 (3): 463–72. PMID 8521476. doi:10.1016/0092-8674(95)90124-8
Yan J, Khanna KK, Lavin MF (1996). «Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation.». Int. J. Radiat. Biol. 69 (5): 539–46. PMID 8648241. doi:10.1080/095530096145544
Quinton TM, Dean WL (1996). «Multiple inositol 1,4,5-trisphosphate receptor isoforms are present in platelets.». Biochem. Biophys. Res. Commun. 224 (3): 740–6. PMID 8713116. doi:10.1006/bbrc.1996.1093
Cameron AM, Nucifora FC, Fung ET; et al. (1997). «FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.». J. Biol. Chem. 272 (44): 27582–8. PMID 9346894. doi:10.1074/jbc.272.44.27582
Deelman LE, Jonk LJ, Henning RH (1998). «The isolation and characterization of the promoter of the human type 1 inositol 1,4,5-trisphosphate receptor.». Gene. 207 (2): 219–25. PMID 9511764. doi:10.1016/S0378-1119(97)00630-6
Martin C, Chapman KE, Seckl JR, Ashley RH (1998). «Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.». Neuroscience. 85 (1): 205–16. PMID 9607712. doi:10.1016/S0306-4522(97)00612-X
Tu JC, Xiao B, Yuan JP; et al. (1998). «Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.». Neuron. 21 (4): 717–26. PMID 9808459. doi:10.1016/S0896-6273(00)80589-9
Kiselyov K, Xu X, Mozhayeva G; et al. (1998). «Functional interaction between InsP3 receptors and store-operated Htrp3 channels.». Nature. 396 (6710): 478–82. PMID 9853757. doi:10.1038/24890
Lin P, Yao Y, Hofmeister R; et al. (1999). «Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi.». J. Cell Biol. 145 (2): 279–89. PMC 2133108. PMID 10209024. doi:10.1083/jcb.145.2.279
Schlossmann J, Ammendola A, Ashman K; et al. (2000). «Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.». Nature. 404 (6774): 197–201. PMID 10724174. doi:10.1038/35004606
Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). «Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.». Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMC 16267. PMID 10737800. doi:10.1073/pnas.97.7.3491
Mayne M, Holden CP, Nath A, Geiger JD (2000). «Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.». J. Immunol. 164 (12): 6538–42. PMID 10843712
Tanimura A, Tojyo Y, Turner RJ (2000). «Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.». J. Biol. Chem. 275 (35): 27488–93. PMID 10874040. doi:10.1074/jbc.M004495200

Ligações externas

MeSH ITPR1+protein,+human

[pmid7945203-1] Yamada N, Makino Y, Clark RA, Pearson DW, Mattei MG, Guenet JL, Ohama E, Fujino I, Miyawaki A, Furuichi T; et al. (1994). «Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization». Biochem J. 302 ( Pt 3): 781–90. PMC 1137299. PMID 7945203

[pmid7500840-2] Nucifora FC Jr, Li SH, Danoff S, Ullrich A, Ross CA (1996). «Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant». Brain Res Mol Brain Res. 32 (2): 291–6. PMID 7500840. doi:10.1016/0169-328X(95)00089-B

[pmid17590087-3] van de Leemput J, Chandran J, Knight MA, Holtzclaw LA, Scholz S, Cookson MR, Houlden H, Gwinn-Hardy K, Fung HC, Lin X, Hernandez D, Simon-Sanchez J, Wood NW, Giunti P, Rafferty I, Hardy J, Storey E, Gardner RJ, Forrest SM, Fisher EM, Russell JT, Cai H, Singleton AB (2007). «Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans». PLoS Genet. 3 (6): e108. PMC 1892049. PMID 17590087. doi:10.1371/journal.pgen.0030108

[pmid17932120-4] Iwaki A, Kawano Y, Miura S, Shibata H, Matsuse D, Li W, Furuya H, Ohyagi Y, Taniwaki T, Kira J, Fukumaki Y (2008). «Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16». J Med Genet. 45 (1): 32–5. PMID 17932120. doi:10.1136/jmg.2007.053942

[entrez-5] «Entrez Gene: ITPR1 inositol 1,4,5-triphosphate receptor, type 1»