KPNA5

KPNA5
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4U2X
Identificadores
Nomes alternativos	KPNA5
IDs externos	OMIM: 604545 HomoloGene: 128489 GeneCards: KPNA5
Ontologia genética
Função molecular	• nuclear localization sequence binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • nuclear import signal receptor activity;
Componente celular	• poro nuclear; • núcleo celular; • cariolinfa; • citoplasma; • citosol;
Processo biológico	• protein transport; • modulation by virus of host cellular process; • NLS-bearing protein import into nucleus; • protein import into nucleus; • GO:0022415 viral process;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	3841
	n/a
	ENSG00000196911
	n/a
	O15131; Q5TD90
	n/a
	NM_002269
	n/a
NP_002260; NP_001353233; NP_001353234; NP_001353235; NP_001353236;
	NP_001353237; NP_001353238; NP_001353239
	n/a
	Wikidata
Ver/Editar Humano

A subunidade alfa-6 da importação é uma proteína que em humanos é codificada pelo gene KPNA5. A proteína KPNA5 pertence à família de proteínas importina α e acredita-se que esteja envolvida na importação de proteínas dependentes de NLS no núcleo.

Referências

↑ «Human PubMed Reference:»
↑ Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (janeiro de 1998). «Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family». FEBS Lett. 417 (1): 104–8. PMID 9395085. doi:10.1016/S0014-5793(97)01265-9
↑ Köhler, Matthias; Speck, Christian; Christiansen, Marret; Bischoff, F. Ralf; Prehn, Siegfried; Haller, Hermann; Görlich, Dirk; Hartmann, Enno (1 de novembro de 1999). «Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import». Molecular and Cellular Biology (em inglês). 19 (11): 7782–7791. ISSN 0270-7306. PMC 84838. PMID 10523667. doi:10.1128/MCB.19.11.7782
↑ «Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)»

Leitura adicional

Bukrinsky MI, Haffar OK (2004). «HIV-1 nuclear import: in search of a leader.». Front. Biosci. 2: d578–87. PMID 9366553. doi:10.2741/A213
Bukrinsky MI, Haffar OK (1998). «HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr.». Mol. Med. 4 (3): 138–43. PMC 2230352. PMID 9562972
Bukrinsky MI, Sharova N, Dempsey MP, et al. (1992). «Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.». Proc. Natl. Acad. Sci. U.S.A. 89 (14): 6580–4. PMC 49545. PMID 1631159. doi:10.1073/pnas.89.14.6580
Sharova N, Bukrinskaya A (1991). «p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells.». AIDS Res. Hum. Retroviruses. 7 (3): 303–6. PMID 2064827. doi:10.1089/aid.1991.7.303
Di Marzio P, Choe S, Ebright M, et al. (1996). «Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.». J. Virol. 69 (12): 7909–16. PMC 189735. PMID 7494303
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). «Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.» (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098
Gallay P, Swingler S, Song J, et al. (1995). «HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase.». Cell. 83 (4): 569–76. PMID 7585960. doi:10.1016/0092-8674(95)90097-7
Freed EO, Englund G, Martin MA (1995). «Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection.». J. Virol. 69 (6): 3949–54. PMC 189124. PMID 7745752
Gallay P, Swingler S, Aiken C, Trono D (1995). «HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.». Cell. 80 (3): 379–88. PMID 7859280. doi:10.1016/0092-8674(95)90488-3
von Schwedler U, Kornbluth RS, Trono D (1994). «The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.». Proc. Natl. Acad. Sci. U.S.A. 91 (15): 6992–6. PMC 44324. PMID 8041734. doi:10.1073/pnas.91.15.6992
Heinzinger NK, Bukinsky MI, Haggerty SA, et al. (1994). «The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.». Proc. Natl. Acad. Sci. U.S.A. 91 (15): 7311–5. PMC 44389. PMID 8041786. doi:10.1073/pnas.91.15.7311
Bukrinsky MI, Haggerty S, Dempsey MP, et al. (1993). «A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.». Nature. 365 (6447): 666–9. PMID 8105392. doi:10.1038/365666a0
Dubrovsky L, Ulrich P, Nuovo GJ, et al. (1996). «Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention.». Mol. Med. 1 (2): 217–30. PMC 2229944. PMID 8529100
Gallay P, Stitt V, Mundy C, et al. (1996). «Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import.». J. Virol. 70 (2): 1027–32. PMC 189908. PMID 8551560
Bukrinskaya AG, Ghorpade A, Heinzinger NK, et al. (1996). «Phosphorylation-dependent human immunodeficiency virus type 1 infection and nuclear targeting of viral DNA.». Proc. Natl. Acad. Sci. U.S.A. 93 (1): 367–71. PMC 40239. PMID 8552640. doi:10.1073/pnas.93.1.367
Sato A, Yoshimoto J, Isaka Y, et al. (1996). «Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion.». Virology. 220 (1): 208–12. PMID 8659115. doi:10.1006/viro.1996.0302
Popov S, Dubrovsky L, Lee MA, et al. (1996). «Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation.». Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11859–64. PMC 38149. PMID 8876228. doi:10.1073/pnas.93.21.11859
Freed EO, Englund G, Maldarelli F, Martin MA (1997). «Phosphorylation of residue 131 of HIV-1 matrix is not required for macrophage infection.». Cell. 88 (2): 171–3; discussion 173–4. PMID 9008157. doi:10.1016/S0092-8674(00)81836-X
Gallay P, Hope T, Chin D, Trono D (1997). «HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.». Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9825–30. PMC 23276. PMID 9275210. doi:10.1073/pnas.94.18.9825
Besançon F, Just J, Bourgeade MF, et al. (1997). «HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase.». J. Interferon Cytokine Res. 17 (8): 461–7. PMID 9282826. doi:10.1089/jir.1997.17.461

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[1] «Human PubMed Reference:»

[pmid9395085-2] Kohler M, Ansieau S, Prehn S, Leutz A, Haller H, Hartmann E (janeiro de 1998). «Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family». FEBS Lett. 417 (1): 104–8. PMID 9395085. doi:10.1016/S0014-5793(97)01265-9

[3] Köhler, Matthias; Speck, Christian; Christiansen, Marret; Bischoff, F. Ralf; Prehn, Siegfried; Haller, Hermann; Görlich, Dirk; Hartmann, Enno (1 de novembro de 1999). «Evidence for Distinct Substrate Specificities of Importin α Family Members in Nuclear Protein Import». Molecular and Cellular Biology (em inglês). 19 (11): 7782–7791. ISSN 0270-7306. PMC 84838. PMID 10523667. doi:10.1128/MCB.19.11.7782

[entrez-4] «Entrez Gene: KPNA5 karyopherin alpha 5 (importin alpha 6)»