Adaptador endossomal/lisossomal tardio, ativador 1 de mapk e mtor
O adaptador endossomal/lisossomal tardio e ativador de MAPK e MTOR 1 é uma proteína que, em humanos, é codificada pelo gene LAMTOR1.
Referências
- ↑ «Human PubMed Reference:»
- ↑ «Entrez Gene: Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1». Consultado em 1 de outubro de 2018
Leitura adicional
- Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M (março de 2009). «The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes». EMBO J. 28 (5): 477–89. PMC 2657578
. PMID 19177150. doi:10.1038/emboj.2008.308 - Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M (outubro de 2009). «A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion». J. Biol. Chem. 284 (40): 27315–26. PMC 2785659. PMID 19654316. doi:10.1074/jbc.M109.041400
- Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM (abril de 2010). «Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids». Cell. 141 (2): 290–303. PMC 3024592. PMID 20381137. doi:10.1016/j.cell.2010.02.024
- Hoshino D, Koshikawa N, Seiki M (janeiro de 2011). «A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC». J. Biol. Chem. 286 (4): 3139–48. PMC 3024806. PMID 21087931. doi:10.1074/jbc.M110.159715
- Malek M, Guillaumot P, Huber AL, Lebeau J, Pétrilli V, Kfoury A, Mikaelian I, Renno T, Manié SN (abril de 2012). «LAMTOR1 depletion induces p53-dependent apoptosis via aberrant lysosomal activation». Cell Death Dis. 3 (4): e300. PMC 3358017. PMID 22513874. doi:10.1038/cddis.2012.39
- Zada S, Noh HS, Baek SM, Ha JH, Hahm JR, Kim DR (novembro de 2015). «Depletion of p18/LAMTOR1 promotes cell survival via activation of p27(kip1) -dependent autophagy under starvation». Cell Biol. Int. 39 (11): 1242–50. PMID 26032166. doi:10.1002/cbin.10497
- Wang L, Skotland T, Berge V, Sandvig K, Llorente A (fevereiro de 2017). «Exosomal proteins as prostate cancer biomarkers in urine: From mass spectrometry discovery to immunoassay-based validation». Eur J Pharm Sci. 98: 80–85. PMID 27664330. doi:10.1016/j.ejps.2016.09.023
- Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J (abril de 2017). «Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling». Mol. Cell. Proteomics. 16 (4): 594–607. PMC 5383781. PMID 28174230. doi:10.1074/mcp.M116.064543
- de Araujo MEG, Naschberger A, Fürnrohr BG, Stasyk T, Dunzendorfer-Matt T, Lechner S, Welti S, Kremser L, Shivalingaiah G, Offterdinger M, Lindner HH, Huber LA, Scheffzek K (outubro de 2017). «Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling». Science. 358 (6361): 377–381. Bibcode:2017Sci...358..377D. PMID 28935770. doi:10.1126/science.aao1583
