RRAGA

RRAGA
Identificadores
Nomes alternativos	RRAGA
IDs externos	OMIM: 612194 HomoloGene: 68522 GeneCards: RRAGA
Ontologia genética
Função molecular	• nucleotide binding; • protein homodimerization activity; • GTP binding; • phosphoprotein binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • GO:0006184 GTPase activity; • ubiquitin protein ligase binding; • protein heterodimerization activity;
Componente celular	• citoplasma; • citosol; • GATOR1 complex; • lysosomal membrane; • lisossoma; • núcleo celular; • Gtr1-Gtr2 GTPase complex;
Processo biológico	• cellular response to amino acid starvation; • morte celular; • positive regulation of cytolysis; • positive regulation of TORC1 signaling; • modulation by virus of host process; • cellular response to amino acid stimulus; • GO:0022415 viral process; • negative regulation of autophagy; • positive regulation of TOR signaling; • GO:0097285 apoptose; • protein ubiquitination; • regulation of macroautophagy; • cellular response to starvation; • regulation of autophagy;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	Mais dados de referência de expressão
Ortólogos
	10670
	n/a
	ENSG00000155876
	n/a
	Q7L523
	n/a
	NM_006570
	n/a
	NP_006561
	n/a
	Wikidata
Ver/Editar Humano

A proteína A ligada ao GTP relacionada com Ras é uma proteína que em humanos é codificada pelo gene RRAGA.

Interações

Foi demonstrado que RRAGA interage com NOL8 e RRAGC.

Referências

↑ «Human PubMed Reference:»
↑ Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (dezembro de 1995). «Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases». The Journal of Biological Chemistry. 270 (48): 28982–8. PMID 7499430. doi:10.1074/jbc.270.48.28982
↑ Li Y, Kang J, Horwitz MS (fevereiro de 1997). «Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers». Journal of Virology. 71 (2): 1576–82. PMC 191215. PMID 8995684. doi:10.1128/JVI.71.2.1576-1582.1997
↑ «Entrez Gene: RRAGA Ras-related GTP binding A»
↑ Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (fevereiro de 2004). «A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D». The Journal of Biological Chemistry. 279 (9): 8343–50. PMID 14660641. doi:10.1074/jbc.M305935200
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (outubro de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209
↑ Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (março de 2001). «Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B». The Journal of Biological Chemistry. 276 (10): 7246–57. PMID 11073942. doi:10.1074/jbc.M004389200

Leitura adicional

Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (janeiro de 1998). «RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway». Journal of Cell Science. 111 ( Pt 1) (1): 11–21. PMID 9394008. doi:10.1242/jcs.111.1.11
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (março de 2001). «Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B». The Journal of Biological Chemistry. 276 (10): 7246–57. PMID 11073942. doi:10.1074/jbc.M004389200
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (fevereiro de 2004). «A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D». The Journal of Biological Chemistry. 279 (9): 8343–50. PMID 14660641. doi:10.1074/jbc.M305935200
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (outubro de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209

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[1] «Human PubMed Reference:»

[pmid7499430-2] Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (dezembro de 1995). «Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases». The Journal of Biological Chemistry. 270 (48): 28982–8. PMID 7499430. doi:10.1074/jbc.270.48.28982

[pmid8995684-3] Li Y, Kang J, Horwitz MS (fevereiro de 1997). «Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers». Journal of Virology. 71 (2): 1576–82. PMC 191215. PMID 8995684. doi:10.1128/JVI.71.2.1576-1582.1997

[entrez-4] «Entrez Gene: RRAGA Ras-related GTP binding A»

[pmid14660641-5] Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (fevereiro de 2004). «A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D». The Journal of Biological Chemistry. 279 (9): 8343–50. PMID 14660641. doi:10.1074/jbc.M305935200

[pmid16189514-6] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (outubro de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209

[pmid11073942-7] Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (março de 2001). «Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B». The Journal of Biological Chemistry. 276 (10): 7246–57. PMID 11073942. doi:10.1074/jbc.M004389200