S100A9

S100A9 (em inglês: S100 calcium binding protein A9) é uma proteína codificada pelo gene humano S100A9.

A proteína codificada por este gene é um membro da família de proteínas denominada S100. As proteínas S100 estão localizadas no citoplasma e/ou núcleo de uma grande variedade de células, e estão envolvidas na regulação de um número de processos celulares como a progressão do ciclo celular e diferenciação celular.. Os genes S100 incluem pelo menos 13 membros que estão localizados no cromossoma 1q21.

S100A9 é um alvo para as quinolina-3-carboxamidas. Estes compostos ligam-se à S100A9 que é expressada na superfície de várias populações de monócitos no sangue periférico e também inibem a interação entre S100A9 e receptores pró-inflamatórios.

Referências

↑ «Entrez Gene: S100A9 S100 calcium binding protein A9» ^{[ligação inativa]}
↑ Björk P, Björk A, Vogl T, Stenström M, Liberg D, et al. (2009) Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides. PLoS Biol 7(4): e1000097. doi:10.1371/journal.pbio.1000097

Leitura de apoio

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[entrez-1] «Entrez Gene: S100A9 S100 calcium binding protein A9» ^{[ligação inativa]}

[2] Björk P, Björk A, Vogl T, Stenström M, Liberg D, et al. (2009) Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides. PLoS Biol 7(4): e1000097. doi:10.1371/journal.pbio.1000097