ZAK
Motivo alfa estéril e zíper de leucina contendo quinase AZK ou MAP3K20, também conhecido como ZAK, é um gene humano. Este gene é um membro da família MAPKKK de moléculas de transdução de sinal e codifica uma proteína com um domínio catalítico de quinase N-terminal, seguido por um motivo zipper de leucina e um motivo alfa estéril (SAM). Esta proteína de ligação ao magnésio forma homodímeros e está localizada no citoplasma. A proteína medeia a sinalização de radiação gama levando à interrupção do ciclo celular e a atividade dessa proteína desempenha um papel na regulação do ponto de verificação do ciclo celular nas células. A proteína também tem atividade pró-apoptótica. Variantes de splice da transcrição alternativa, codificando diferentes isoformas, foram caracterizadas. Mutações em ZAK estão por trás da deformidade da mão e do pé.
Interações
ZAK demonstrou interagir com ZNF33A.
Referências
- ↑ «Doenças geneticamente associadas a MAP3K20 ver/editar referências no wikidata»
- ↑ «Human PubMed Reference:»
- ↑ «MAP3K20 mitogen-activated protein kinase kinase kinase 20 [Homo sapiens (human)] - Gene - NCBI». www.ncbi.nlm.nih.gov. Consultado em 8 de agosto de 2020
- ↑ «Sterile-Alpha Motif and Leucine Zipper-Containing Kinase AZK (ZAK)». Cham: Springer International Publishing. 2018: 5182–5182. ISBN 978-3-319-67198-7
- ↑ CRISPR Clarifies Split-Hand/Foot [ligação inativa] por Ricki Lewis (2016)
- ↑ Yang, Jaw-Ji (janeiro de 2003). «A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle». Biochemical and Biophysical Research Communications. 301 (1): 71–77. ISSN 0006-291X. doi:10.1016/s0006-291x(02)02980-7
Leitura adicional
- Liu TC, Huang CJ, Chu YC, et al. (2000). «Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.». Biochem. Biophys. Res. Commun. 274 (3): 811–6. PMID 10924358. doi:10.1006/bbrc.2000.3236
- Gotoh I, Adachi M, Nishida E (2001). «Identification and characterization of a novel MAP kinase kinase kinase, MLTK.». J. Biol. Chem. 276 (6): 4276–86. PMID 11042189. doi:10.1074/jbc.M008595200
- Bloem LJ, Pickard TR, Acton S, et al. (2002). «Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase.». J. Mol. Cell. Cardiol. 33 (9): 1739–50. PMID 11549352. doi:10.1006/jmcc.2001.1437
- Gross EA, Callow MG, Waldbaum L, et al. (2002). «MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.». J. Biol. Chem. 277 (16): 13873–82. PMID 11836244. doi:10.1074/jbc.M111994200
- Yang JJ (2002). «Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest.». Biochem. Biophys. Res. Commun. 297 (1): 105–10. PMID 12220515. doi:10.1016/S0006-291X(02)02123-X
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899 - Yang JJ (2003). «A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.». Biochem. Biophys. Res. Commun. 301 (1): 71–7. PMID 12535642. doi:10.1016/S0006-291X(02)02980-7
- Takahashi M, Gotoh Y, Isagawa T, et al. (2004). «Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.». J. Biochem. 133 (2): 181–7. PMID 12761180. doi:10.1093/jb/mvg022
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285
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- Huang CY, Kuo WW, Chueh PJ, et al. (2004). «Transforming growth factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK.». Biochem. Biophys. Res. Commun. 324 (1): 424–31. PMID 15465036. doi:10.1016/j.bbrc.2004.09.067
- Huang CY, Chueh PJ, Tseng CT, et al. (2004). «ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells.». Biochem. Biophys. Res. Commun. 324 (3): 973–80. PMID 15485649. doi:10.1016/j.bbrc.2004.09.156
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
- Choi HS, Choi BY, Cho YY, et al. (2005). «Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.». J. Biol. Chem. 280 (14): 13545–53. PMID 15684425. doi:10.1074/jbc.M410521200
- Wang X, Mader MM, Toth JE, et al. (2005). «Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.». J. Biol. Chem. 280 (19): 19298–305. PMID 15737997. doi:10.1074/jbc.M413059200
- Benzinger A, Muster N, Koch HB, et al. (2005). «Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.». Mol. Cell. Proteomics. 4 (6): 785–95. PMID 15778465. doi:10.1074/mcp.M500021-MCP200
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